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2D Structure
Also known as: Chlorine base compound, 7681-52-9, Antiformin, Clorox, Hypochlorous acid, sodium salt, Sodium oxychloride
Molecular Formula
ClNaO
Molecular Weight
74.44  g/mol
InChI Key
SUKJFIGYRHOWBL-UHFFFAOYSA-N
FDA UNII
DY38VHM5OD

It is used as an oxidizing and bleaching agent and as a disinfectant. (From Grant and Hackh's Chemical Dictionary, 5th ed)
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;hypochlorite
2.1.2 InChI
InChI=1S/ClO.Na/c1-2;/q-1;+1
2.1.3 InChI Key
SUKJFIGYRHOWBL-UHFFFAOYSA-N
2.1.4 Canonical SMILES
[O-]Cl.[Na+]
2.2 Other Identifiers
2.2.1 UNII
DY38VHM5OD
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Antiformin

2. Clorox

3. Hypochlorite, Sodium

4. Sodium Hypochlorite (solution)

2.3.2 Depositor-Supplied Synonyms

1. Chlorine Base Compound

2. 7681-52-9

3. Antiformin

4. Clorox

5. Hypochlorous Acid, Sodium Salt

6. Sodium Oxychloride

7. Household Bleach

8. Dakin's Solution

9. Chlorox

10. Javex

11. Javelle Water

12. Hypochlorite Sodium

13. Sodium Hypochlorite Solution

14. Sodiumhypochlorite

15. Sodium;hypochlorite

16. Texant

17. Dental Antiformin

18. Naclo

19. Naocl

20. Sodium Hypochloride

21. Natrum Hypochlorosum

22. Dy38vhm5od

23. Hypochlorous Acid, Sodium Salt (1:1)

24. Chebi:32146

25. Ncgc00091027-01

26. Carrel-dakin Solution

27. Chloros

28. Cloralex

29. Cloropool

30. Dispatch

31. Hyclorite

32. Klorocin

33. Parozone

34. Surchlor

35. Youxiaolin

36. Deosan

37. Hypure

38. Milton

39. Dakins Solution

40. Hospital Milton

41. Milton Crystals

42. Neo-cleaner

43. Neoseptal Cl

44. Hypure N

45. Sodium Hypochlorite [solution, Diluted]

46. Purin B

47. B-k Liquid

48. Modified Dakin's Solution

49. Hyposan And Voxsan

50. Solutions, Dakin's

51. Ad Gel

52. Clorox Liquid Bleach

53. Sunnysol 150

54. Caswell No. 776

55. Dakins Quarter

56. Sodium Hypochlorite Solution (available Chlorine 10-15 Per Cent)

57. Dakins Half

58. Di-dak-sol

59. Sodium Hypochlorite (naclo)

60. Sodium Hypochlorite (naocl)

61. Ccris 708

62. Deosan Green Label Steriliser

63. Hsdb 748

64. Xy 12

65. Einecs 231-668-3

66. Unii-dy38vhm5od

67. Epa Pesticide Chemical Code 014703

68. Un 1791

69. Sodium Hypochlorite [usp:jan]

70. Sodium Hypochiorite

71. Sodium Hypo Chlorite

72. Mfcd00011120

73. Texant (tn)

74. Chlorinated Water (sodium Hypochlorite)

75. Sodium Hypochlorite [hypochloride Salts]

76. Sodium Hypochlorite Solution (15% Or Less)

77. Antiformin, Dental

78. Dsstox_cid_1276

79. Ec 231-668-3

80. Dsstox_rid_76052

81. Dsstox_gsid_21276

82. Sodium Hypochlorite (jan/usp)

83. Chembl1334078

84. Dtxsid8021276

85. Sodium Hypochlorite [ii]

86. Sodium Hypochlorite [mi]

87. Sodium Hypochlorite [jan]

88. Sodium Hypochlorite [hsdb]

89. Sodium Hypochlorite [inci]

90. Natrum Hypochlorosum [hpus]

91. Sodium Hypochlorite [vandf]

92. Sodium Hypochlorite [mart.]

93. Str00665

94. Sodium Hypochlorite Solution 6-14%

95. Tox21_111062

96. Sodium Hypochlorite [who-dd]

97. Akos015950665

98. Sodium Hypochlorite [usp Impurity]

99. Cas-7681-52-9

100. S0939

101. 7681-52-910022-70-5(pentahydrate)

102. D01711

103. Q407204

104. Q-200732

105. Sodium Hypochlorite, Aqueous Solution, 12-15% Available Chlorine

2.4 Create Date
2008-02-05
3 Chemical and Physical Properties
Molecular Weight 74.44 g/mol
Molecular Formula ClNaO
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass73.9535366 g/mol
Monoisotopic Mass73.9535366 g/mol
Topological Polar Surface Area23.1 Ų
Heavy Atom Count3
Formal Charge0
Complexity4.8
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Therapeutic Uses

Disinfectants; Oxidants

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


For surgical purposes, diluted sodium hypochlorite soln is used; it contains 0.45 to 0.5% sodium hypochlorite and it may be further diluted 1:3. ... It is used to loosen and help dissolve and deodorize necrotic tissue. ... Diluted sodium hypochlorite soln may be used to irrigate ragged or dirty wounds, as an antiseptic in certain peritoneal dialysis system.

Gilman, A.G., L.S.Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 7th ed. New York: Macmillan Publishing Co., Inc., 1985., p. 964


IT WAS ONCE WIDELY USED TO TREAT SUPPURATING WOUNDS, BUT HAS A SOLVENT ACTION ON BLOOD CLOTS AND THUS DELAYS CLOTTING.

American Medical Association, Department of Drugs. Drug Evaluations. 6th ed. Chicago, Ill: American Medical Association, 1986., p. 1526


For prophylaxis of epidermophytosis, diluted sodium hypochlorite soln is ... used as a foot bath. Soln is also a deodorant. /Sodium hypochlorite soln, diluted/

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1112


MEDICATION (VET): Antiseptic for wound irrigation /Sodium hypochlorite, diluted/

The Merck Index. 10th ed. Rahway, New Jersey: Merck Co., Inc., 1983., p. 1236


4.2 Drug Warning

For surgical purposes, diluted sodium hypochlorite soln is used; it contains 0.45 to 0.5% sodium hypochlorite and it may be further diluted 1:3. ... It is used to loosen and help dissolve and deodorize necrotic tissue. ... It is irritating to the skin unless rinsed off promptly.

Gilman, A.G., L.S.Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 7th ed. New York: Macmillan Publishing Co., Inc., 1985., p. 964


Topically applied hypochlorites may dissolve blood clots and cause bleeding. Sodium hypochlorite could interfere with the Clinistix and Labstix qualitative urine tests for glucose to produce false positive results. ... Traces of sodium hypochlorite soln adhering to utensils for preparing feeds of pooled human milk for premature infants incr dietary sodium intake by 50% in a series of 9 paired estimations.

Reynolds, J.E.F., Prasad, A.B. (eds.) Martindale-The Extra Pharmacopoeia. 28th ed. London: The Pharmaceutical Press, 1982., p. 574


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Disinfectants

Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed) (See all compounds classified as Disinfectants.)


Oxidants

Electron-accepting molecules in chemical reactions in which electrons are transferred from one molecule to another (OXIDATION-REDUCTION). (See all compounds classified as Oxidants.)


5.2 ATC Code

D - Dermatologicals

D08 - Antiseptics and disinfectants

D08A - Antiseptics and disinfectants

D08AX - Other antiseptics and disinfectants

D08AX07 - Sodium hypochlorite


5.3 Metabolism/Metabolites

Trichloroacetic acid was found in the gut contents & plasma of fasted & nonfasted rats 1 hr after dosing with sodium hypochlorite. Thus, the formation is not dependent on the interaction of sodium hypochlorite with foreign organic material in the gut. Dichloroacetic acid was also found in all treated animals. Chloroform generally was present when trichloroacetic acid was detected. Dichloroacetonitrile was found in the gut contents of 2 of 3 nonfasted rats treated with sodium hypochlorite. Addition of 8 mg sodium hypochlorite/ml to nonfasted rat gut contents in vitro produced dichloroacetic acid, trichloroacetic acid, dichloroacetonitrile, & trichloroacetonitrile.

PMID:6850127 Mink FL et al; Bull Environ Contam Toxicol 30 (4): 394-9 (1983)


5.4 Mechanism of Action

ITS TOXIC EFFECT IS DUE TO PRESENCE OF CHLORINE.

International Labour Office. Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva, Switzerland: International Labour Office, 1983., p. 299