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    Sodium Propionate

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    GLOBAL SALES INFORMATION

    REF. STANDARDS & IMPURITIES

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    $ API Ref.Price (USD/KG) : 3Xls

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    2D Structure
    Also known as: 137-40-6, Sodium propanoate, Propionic acid sodium salt, Propanoic acid, sodium salt, Sodium;propanoate, Sodiumpropionate
    Molecular Formula
    C3H5NaO2
    Molecular Weight
    96.06  g/mol
    InChI Key
    JXKPEJDQGNYQSM-UHFFFAOYSA-M
    FDA UNII
    DK6Y9P42IN
    Sodium Propionate is the sodium salt form of propionic acid, a short chain fatty acid (SCFA) and food additive, with potential gastrointestinal (GI) protective activity. Upon oral administration of sodium propionate, it converts to propionic acid which may protect the GI tract and reduce incidence and severity of GI toxicity from radiation therapy.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;propanoate
    2.1.2 InChI
    InChI=1S/C3H6O2.Na/c1-2-3(4)5;/h2H2,1H3,(H,4,5);/q;+1/p-1
    2.1.3 InChI Key
    JXKPEJDQGNYQSM-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    CCC(=O)[O-].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    DK6Y9P42IN
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Prophyllin

    2.3.2 Depositor-Supplied Synonyms

    1. 137-40-6

    2. Sodium Propanoate

    3. Propionic Acid Sodium Salt

    4. Propanoic Acid, Sodium Salt

    5. Sodium;propanoate

    6. Sodiumpropionate

    7. Propionic Acid, Sodium Salt

    8. Sodium Propionate Anhydrous

    9. Natriumpropionat

    10. Mycoban

    11. Propanoic Acid, Sodium Salt (1:1)

    12. Dk6y9p42in

    13. Mycoban; Napropion; Ocuseptine

    14. Ocuseptine

    15. Napropion

    16. Bioban-s

    17. Deketon

    18. E281

    19. Impedex

    20. Keenate

    21. Propiofar

    22. Propisol

    23. Sodium Dipropionate

    24. Propi-ophtal

    25. Whit-pro

    26. Dsstox_cid_1996

    27. Dsstox_rid_76449

    28. Dsstox_gsid_21996

    29. Caswell No. 707a

    30. Propionan Sodny

    31. Propionan Sodny [czech]

    32. Natriumpropionat [german]

    33. Chembl500826

    34. Cas-137-40-6

    35. Ccris 1896

    36. Hsdb 766

    37. Propanoic Acid, Sodium Salt (2:1)

    38. Ncgc00159468-02

    39. Einecs 205-290-4

    40. Epa Pesticide Chemical Code 077703

    41. Propionic Acid Sodium

    42. Unii-dk6y9p42in

    43. Sodium Propionate [ii]

    44. Sodium Propionate [mi]

    45. Ins No.281

    46. Sodium Propionate [fcc]

    47. Dtxsid7021996

    48. Sodium Propionate [inci]

    49. Ins-281

    50. Sodium Propionate [vandf]

    51. Anhydrous Sodium Propionate

    52. Chebi:132106

    53. Sodium Propionate [mart.]

    54. 391o0po49r

    55. Sodium Propionate [usp-rs]

    56. Sodium Propionate [who-dd]

    57. Amy22300

    58. Natriumpropionat [veterinary] (tn)

    59. Einecs 264-460-6

    60. Tox21_113044

    61. Tox21_202735

    62. Mfcd00002759

    63. Akos003051488

    64. Akos015892835

    65. Sodium Propionate [ep Monograph]

    66. Ncgc00260283-01

    67. Sodium Propionate Anhydrous [hsdb]

    68. Anhydrous Sodium Propionate [mart.]

    69. E-281

    70. Ft-0655038

    71. P0512

    72. D08440

    73. A807253

    74. Q420130

    75. J-007019

    2.4 Create Date
    2005-07-19
    3 Chemical and Physical Properties
    Molecular Weight 96.06 g/mol
    Molecular Formula C3H5NaO2
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count1
    Exact Mass96.01872368 g/mol
    Monoisotopic Mass96.01872368 g/mol
    Topological Polar Surface Area40.1 Ų
    Heavy Atom Count6
    Formal Charge0
    Complexity44.1
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    MANY PROPRIETARY PREPARATIONS ARE AVAILABLE FOR TREATING DERMATOPHYTIC INFECTIONS, ESPECIALLY TINEA PEDIS (ATHLETE'S FOOT). THESE INCLUDE ... SODIUM PROPIONATE ...

    American Medical Association, AMA Department of Drugs, AMA Drug Evaluations. 3rd ed. Littleton, Massachusetts: PSG Publishing Co., Inc., 1977., p. 822

    CLINICALLY, MEDICATION: SODIUM PROPIONATE IS USED IN TREATMENT OF OTOMYCOSIS. IT IS ALSO USED IN TREATMENT OF EPIDERMOPHYTOSIS, BUT IT IS NOT AS EFFECTIVE AS MOST OTHER AGENTS FOR THIS CONDITION. IT IS NOT FUNGICIDAL, SO THAT OTHER HYGIENE MEASURES MUST BE EMPHASIZED. ... DOSE--TOPICAL, IN DOSAGE FORMS CONTAINING 0.5-10% OF SODIUM PROPIONATE.

    Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1177

    MEDICATION (VET): ALTHOUGH SOME COWS FIND HIGH DOSAGE (250 G) UNPALATABLE & IT MAY LACK SUBSTANTIAL EFFECTIVENESS AS PROPHYLACTIC & THERAPEUTIC AGENT IN ACETONEMIA, IT IS A USEFUL ADJUNCT TO THERAPY & ITS BENEFICIAL EFFECTS ON MILK PRODUCTION HAVE BEEN ATTRIBUTED TO CONTROL OF SUBCLINICAL KETOSIS.

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 545

    MEDICATION (VET): EFFECTIVE IN EARLY TREATMENT OF KETOSIS OF CATTLE OR AS FOLLOWUP TREATMENT AFTER DEXTROSE THERAPY OF THIS DISEASE.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1168

    For more Therapeutic Uses (Complete) data for SODIUM PROPIONATE (6 total), please visit the HSDB record page.

    5 Pharmacology and Biochemistry
    5.1 ATC Code

    S - Sensory organs

    S01 - Ophthalmologicals

    S01A - Antiinfectives

    S01AX - Other antiinfectives

    S01AX10 - Sodium propionate

    5.2 Absorption, Distribution and Excretion

    SRP: In an acidic medium propionic acid is rapidly absorbed.

    5.3 Metabolism/Metabolites

    INCORPORATION RATE OF SPECIFICALLY LABELED SODIUM PROPIONATE INTO METHYLMALONATE & TRICARBOXYLIC ACID CYCLE INTERMEDIATES STUDIED. INCORPORATION OF (14)C FROM SODIUM PROPIONATE INTO METABOLIC INTERMEDIATES BEYOND METHYLMALONATE WAS POSITIVELY CORRELATED WITH LIVER VITAMIN B-12 CONCN.

    PMID:6070000 MATHIAS MM, ELLIOT JM; J DAIRY SCI 50 (12): 1935-40 (1967)

    MICE RECEIVED IV LABELED SODIUM PROPIONATE. ANALYSIS OF TOTAL BODY FATTY ACIDS 12 MIN LATER SHOWED 89 & 11 OF THE LABELS TO BE INCORPORATED INTO ODD-NUMBERED & EVEN-NUMBERED FATTY ACIDS, RESPECTIVELY. RESULTS CONFIRMED PROPOSED DEMETHYLATION OF PROPIONIC ACID IN VIVO.

    FAVARGER P, GERLACH J; HELV CHIM ACTA 49 (1): 506-9 (1966)