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    Sodium Sulfite

    ACTIVE PHARMA INGREDIENTS

    DIGITAL CONTENT

    MARKET PLACE

    PharmaCompass
    $ API Ref.Price (USD/KG) : 4,810Xls

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    2D Structure
    Also known as: 7757-83-7, Sodium sulphite, Sodium sulfite anhydrous, Disodium sulfite, Sulfurous acid, disodium salt, Natrium sulfurosum
    Molecular Formula
    Na2O3S
    Molecular Weight
    126.05  g/mol
    InChI Key
    GEHJYWRUCIMESM-UHFFFAOYSA-L
    FDA UNII
    VTK01UQK3G
    Sodium Sulfite is a white crystal or powder with reducing property. Sodium sulfite exhibits bleaching, de-sulfurizing, and dechlorinating activities. This agent was used by food industry to help maintain the fresh appearance of food products. It is also a component in many drugs, which helps maintain their potency and stability. FDA has ruled sodium sulfite a new animal drug of low regulatory priority.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    disodium;sulfite
    2.1.2 InChI
    InChI=1S/2Na.H2O3S/c;;1-4(2)3/h;;(H2,1,2,3)/q2*+1;/p-2
    2.1.3 InChI Key
    GEHJYWRUCIMESM-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    [O-]S(=O)[O-].[Na+].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    VTK01UQK3G
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Sodium Sulfite, 35s-labeled Cpd

    2. Sodium Sulfite, Heptahydrate

    3. Sodium Sulphite

    4. Sulfurous Acid, Sodium Salt

    2.3.2 Depositor-Supplied Synonyms

    1. 7757-83-7

    2. Sodium Sulphite

    3. Sodium Sulfite Anhydrous

    4. Disodium Sulfite

    5. Sulfurous Acid, Disodium Salt

    6. Natrium Sulfurosum

    7. S-wat

    8. Natriumsulfid

    9. Natriumsulfit

    10. Anhydrous Sodium Sulfite

    11. Sodium Sulfite (na2so3)

    12. Sulfurous Acid, Sodium Salt

    13. Sodium Sulfite, Anhydrous

    14. Natrum Sulphurosum

    15. Sulfurous Acid, Sodium Salt (1:2)

    16. Dried Sodium Sulfite

    17. Sodium Sulfite [nf]

    18. Anhydrous Sodium Sulphite

    19. Na2so3

    20. Sodium Sulphite Anhydrous

    21. Mfcd00003503

    22. Vtk01uqk3g

    23. Ins No.221

    24. Sulftech

    25. Chebi:86477

    26. Ins-221

    27. Sodium Sulfite (nf)

    28. Sodiumsulfite

    29. Natrii Sulphis

    30. Natriumsulfid [german]

    31. Natriumsulfit [german]

    32. Exsiccated Sodium Sulfite

    33. Sodium Sulfite, Exsiccated

    34. Disodium Sulfite (na2so3)

    35. Ccris 1429

    36. Hsdb 5043

    37. Sodium Sulfite Solution

    38. Sodium Sulfite (2:1)

    39. Einecs 231-821-4

    40. Unii-vtk01uqk3g

    41. Sodium-sulfite

    42. Ec 231-821-4

    43. Sodium Sulfite [ii]

    44. Sodium Sulfite [mi]

    45. Sodium Sulfite [fcc]

    46. Sodium Sulfite [hsdb]

    47. Sodium Sulfite [inci]

    48. Dried Sodium Sulfite (jp17)

    49. Sodium Sulfite [vandf]

    50. Sodium Sulfite [mart.]

    51. Chembl1945334

    52. Dtxsid2044260

    53. Sodium Sulfite Acs Reagent Grade

    54. Natrum Sulphurosum [hpus]

    55. Dried Sodium Sulfite [jp]

    56. Dried Sodium Sulfite [jan]

    57. Sodium Sulfite [ep Monograph]

    58. Sodium Sulfite Anhydrous, Photo Grade

    59. Akos028109676

    60. Bp-21395

    61. Ft-0645146

    62. D09002

    63. Sodium Sulfite, Anhydrous [ep Impurity]

    64. Q407806

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 126.05 g/mol
    Molecular Formula Na2O3S
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count0
    Exact Mass125.93635360 g/mol
    Monoisotopic Mass125.93635360 g/mol
    Topological Polar Surface Area82.4 Ų
    Heavy Atom Count6
    Formal Charge0
    Complexity18.8
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Vet: antioxidant, antiseptic

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 547

    4.2 Minimum/Potential Fatal Human Dose

    See sulfite salts. 3. 3= Moderately toxic: probable oral lethal dose (human) 0.5-5 g/kg, between 1 oz and 1 pint (or 1 lb) for 70 kg person (150 lb). /Sulfite salts/

    Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-123

    5 Pharmacology and Biochemistry
    5.1 Absorption, Distribution and Excretion

    Skin penetration would be low due to the highly charged nature of these particles and any sulfite that did penetrate would be converted to sulfate by the enzyme sulfate oxidase.

    PMID:14555420 Nair B, Elmore AR; Int J Toxicol 22 (Suppl 2) :63-88 (2003)

    5.2 Metabolism/Metabolites

    Sulfites that enter mammals via ingestion, inhalation, or injection are metabolized by sulfite oxidase to sulfate.

    PMID:14555420 Nair B, Elmore AR; Int J Toxicol 22 (Suppl 2) :63-88 (2003)