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    Solriamfetol Hydrochloride

    ACTIVE PHARMA INGREDIENTS

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    FINISHED DOSAGE FORMULATIONS

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    $ API Ref.Price (USD/KG) : 3,107Xls

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    2D Structure
    Also known as: Jzp-110 hydrochloride, 178429-65-7, Solriamfetol (hydrochloride), K7ro88sp7a, Solriamfetol hydrochloride [usan], Solriamfetol hydrochloride (usan)
    Molecular Formula
    C10H15ClN2O2
    Molecular Weight
    230.69  g/mol
    InChI Key
    KAOVAAHCFNYXNJ-SBSPUUFOSA-N
    FDA UNII
    K7RO88SP7A
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(2R)-2-amino-3-phenylpropyl] carbamate;hydrochloride
    2.1.2 InChI
    InChI=1S/C10H14N2O2.ClH/c11-9(7-14-10(12)13)6-8-4-2-1-3-5-8;/h1-5,9H,6-7,11H2,(H2,12,13);1H/t9-;/m1./s1
    2.1.3 InChI Key
    KAOVAAHCFNYXNJ-SBSPUUFOSA-N
    2.1.4 Canonical SMILES
    C1=CC=C(C=C1)CC(COC(=O)N)N.Cl
    2.1.5 Isomeric SMILES
    C1=CC=C(C=C1)C[C@H](COC(=O)N)N.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    K7RO88SP7A
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (2r)-2-amino-3-phenylpropyl Carbamate

    2. (r)-2-amino-3-phenylpropylcarbamate Hydrochloride

    3. Adx-n05

    4. Benzenepropanol, Beta-amino-, Carbamate (ester), (betar)-

    5. Jzp-110

    6. Solriamfetol

    7. Sunosi

    2.3.2 Depositor-Supplied Synonyms

    1. Jzp-110 Hydrochloride

    2. 178429-65-7

    3. Solriamfetol (hydrochloride)

    4. K7ro88sp7a

    5. Solriamfetol Hydrochloride [usan]

    6. Solriamfetol Hydrochloride (usan)

    7. R-228060

    8. Sunosi (tn)

    9. Unii-k7ro88sp7a

    10. Adx-n05 Hydrochloride

    11. Ykp-10a Hydrochloride

    12. Schembl8430382

    13. Adx-n-05 Hydrochloride

    14. Skl-n-05 Hydrochloride

    15. Chembl4297212

    16. Dtxsid101027927

    17. R-228060 Hydrochloride

    18. Hy-109043a

    19. Solriamfetol Hydrochloride [mi]

    20. Solriamfetol Hydrochloride [who-dd]

    21. Cs-0112102

    22. O-carbamoyl-(d)-phenylalaninol Hydrochloride

    23. D11328

    24. Solriamfetol Hydrochloride [orange Book]

    25. (d)-o-carbamoylphenylalaninol Hydrochloride Salt

    26. R228060;jzp-110;adx-n05;skl-n05;ykp-10

    27. (2r)-2-amino-3-phenylpropyl Carbamate, Monohydrochloride

    28. (betar)-beta-amino-benzenepropanol 1-carbamate Hydrochloride (1:1)

    29. (r)-(+)-2-amino-1-carbamoyloxy-3-phenylpropane Hydrochloride

    30. Benzenepropanol, .beta.-amino-, 1-carbamate, Hydrochloride (1:1), (.beta.r)-

    31. 561069-23-6

    2.4 Create Date
    2012-11-30
    3 Chemical and Physical Properties
    Molecular Weight 230.69 g/mol
    Molecular Formula C10H15ClN2O2
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count5
    Exact Mass230.0822054 g/mol
    Monoisotopic Mass230.0822054 g/mol
    Topological Polar Surface Area78.3 Ų
    Heavy Atom Count15
    Formal Charge0
    Complexity179
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Indication

    Sunosi is indicated to improve wakefulness and reduce excessive daytime sleepiness in adult patients with narcolepsy (with or without cataplexy).

    Sunosi is indicated to improve wakefulness and reduce excessive daytime sleepiness (EDS) in adult patients with obstructive sleep apnoea (OSA) whose EDS has not been satisfactorily treated by primary OSA therapy, such as continuous positive airway pressure (CPAP).

    5 Pharmacology and Biochemistry
    5.1 ATC Code

    N06BA14