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    ST101

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

    DIGITAL CONTENT

    PharmaCompass
    $ API Ref.Price (USD/KG) : 7Xls

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    2D Structure
    Also known as: 887603-94-3, St-101, Zset1446, Zset-1446, St101, 1',3'-dihydro-2h-spiro[imidazo[1,2-a]pyridine-3,2'-inden]-2-one
    Molecular Formula
    C15H12N2O
    Molecular Weight
    236.27  g/mol
    InChI Key
    QZWYXEBIQWJXAR-UHFFFAOYSA-N
    FDA UNII
    7TTT61784C
    C/EBP Beta Antagonist ST101 is a peptide antagonist of the transcription factor CCAAT/enhancer-binding protein beta (C/EBP beta), with potential antineoplastic activity. Upon administration, C/EBP beta antagonist ST101 targets and inhibits the activity of C/EBP beta. This prevents the expression of C/EBP beta target genes and proteins, including the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), cyclins and inhibitor of differentiation (ID) family of proteins, which are involved in cell proliferation, differentiation, and cell cycle regulation. This may lead to apoptosis in tumor cells. C/EBP beta is overexpressed in many cancers and plays an important role in the regulation of cell differentiation; its expression is associated with tumor cell survival and proliferation.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    spiro[1,3-dihydroindene-2,3'-imidazo[1,2-a]pyridine]-2'-one
    2.1.2 InChI
    InChI=1S/C15H12N2O/c18-14-15(17-8-4-3-7-13(17)16-14)9-11-5-1-2-6-12(11)10-15/h1-8H,9-10H2
    2.1.3 InChI Key
    QZWYXEBIQWJXAR-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1C2=CC=CC=C2CC13C(=O)N=C4N3C=CC=C4
    2.2 Other Identifiers
    2.2.1 UNII
    7TTT61784C
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Spiro(imidazo-(1,2-a)pyridine-3,2-indan)-2(3h)-one

    2. St 101

    3. St-101

    4. St101 Cpd

    5. Zset 1446

    6. Zset1446

    2.3.2 Depositor-Supplied Synonyms

    1. 887603-94-3

    2. St-101

    3. Zset1446

    4. Zset-1446

    5. St101

    6. 1',3'-dihydro-2h-spiro[imidazo[1,2-a]pyridine-3,2'-inden]-2-one

    7. 7ttt61784c

    8. Spiro[1,3-dihydroindene-2,3'-imidazo[1,2-a]pyridine]-2'-one

    9. Unii-7ttt61784c

    10. Spiro[imidazo[1,2-a]pyridine-3(2h),2'-[2h]inden]-2-one, 1',3'-dihydro-

    11. Schembl543559

    12. Chembl4297437

    13. Bcp33073

    14. Zinc1491487

    15. St 101(zset1446)

    16. Mfcd09970869

    17. Cs-6039

    18. Db12621

    19. Sb18912

    20. Hy-11013

    21. Sy264852

    22. A13764

    23. F50512

    24. Q27268838

    25. St-101; Zset1446; St101; Zset 1446; St 101

    26. 1',3'-dihydrospiro[imidazo[1,2-a]pyridine-3(2h),2'-[2h]inden]-2-one

    27. 1,3-dihydro-2h-spiro[imidazo[1,2-a]pyridine-3,2-inden]-2-one

    28. 1 Inverted Exclamation Mark ,3 Inverted Exclamation Mark -dihydro-2h-spiro[imidazo[1,2-a]pyridine-3,2 Inverted Exclamation Mark -inden]-2-one

    2.4 Create Date
    2006-10-25
    3 Chemical and Physical Properties
    Molecular Weight 236.27 g/mol
    Molecular Formula C15H12N2O
    XLogP31.9
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count1
    Rotatable Bond Count0
    Exact Mass236.094963011 g/mol
    Monoisotopic Mass236.094963011 g/mol
    Topological Polar Surface Area32.7 Ų
    Heavy Atom Count18
    Formal Charge0
    Complexity475
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1