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    Staurosporine

    ACTIVE PHARMA INGREDIENTS

    PharmaCompass
    $ API Ref.Price (USD/KG) : 40,232Xls

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    2D Structure
    Also known as: Staurosporin, 62996-74-1, (+)-staurosporine, Antibiotic 230, Am-2282, Antibiotic am 2282
    Molecular Formula
    C28H26N4O3
    Molecular Weight
    466.5  g/mol
    InChI Key
    HKSZLNNOFSGOKW-FYTWVXJKSA-N
    FDA UNII
    H88EPA0A3N
    An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one
    2.1.2 InChI
    InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
    2.1.3 InChI Key
    HKSZLNNOFSGOKW-FYTWVXJKSA-N
    2.1.4 Canonical SMILES
    CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
    2.1.5 Isomeric SMILES
    C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
    2.2 Other Identifiers
    2.2.1 UNII
    H88EPA0A3N
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 8,12-epoxy-1h,8h-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-

    2.3.2 Depositor-Supplied Synonyms

    1. Staurosporin

    2. 62996-74-1

    3. (+)-staurosporine

    4. Antibiotic 230

    5. Am-2282

    6. Antibiotic Am 2282

    7. Ccris 3272

    8. Antibiotic Am-2282

    9. Alkaloid Am-2282 From Streptomyces

    10. H88epa0a3n

    11. Chembl388978

    12. Chebi:15738

    13. C28h26n4o3

    14. 8,12-epoxy-1h,8h-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-

    15. (5s,6r,7r,9r)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5h,14h-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14-one

    16. (5s,6r,7r,9r)-6-methoxy-5-methyl-7-methylamino-6,7,8,9,15,16-hexahydro-5h,14h-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one

    17. Unii-h88epa0a3n

    18. Gnf-pf-1389

    19. Methoxy-methyl-(methylamino)[?]one

    20. Sr-00000001485

    21. Cgp-39360

    22. Dtxsid6041131

    23. Staurosporin, 4

    24. 1nvr

    25. 1stc

    26. 1xbc

    27. 1xjd

    28. 1yhs

    29. 2gcd

    30. Staurosporine, 8

    31. Cgp 39360

    32. Staurosporine & Tnf

    33. 1q3d

    34. 1sm2

    35. 2dq7

    36. Staurosporine [mi]

    37. Molmap_000047

    38. Schembl8157

    39. Cbiol_001978

    40. Bspbio_001146

    41. Gtpl346

    42. Bdbm2579

    43. Megxm0_000307

    44. 1u59

    45. Bcpp000063

    46. Bio1_000264

    47. Bio1_000753

    48. Bio1_001242

    49. Hms1990j07

    50. Hms3650b17

    51. Ex-a1777

    52. Zinc3814434

    53. Am2282

    54. Mfcd18252446

    55. Nsc755774

    56. S1421

    57. Staurosporin And Antibiotic Am-2282

    58. Akos015897119

    59. Am 2282

    60. Ccg-208052

    61. Db02010

    62. Nsc-755774

    63. Qtl1_000078

    64. Ncgc00162400-01

    65. Ncgc00162400-02

    66. Ncgc00162400-03

    67. Ncgc00162400-04

    68. Ncgc00162400-05

    69. Ncgc00162400-06

    70. Ncgc00162400-09

    71. 9,13-epoxy-1h,9h-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)-benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9s-(9alpha,10beta,11beta,13alpha)-

    72. Ac-35765

    73. Hy-15141

    74. Staurosporine & Tumor Necrosis Factor (tnf)

    75. Staurosporine 100 Microg/ml In Acetonitrile

    76. T4000

    77. Q5957181

    78. Sr-00000001485-4

    79. Brd-k17953061-001-02-8

    80. Brd-k17953061-001-04-4

    81. Brd-k17953061-001-05-1

    82. Brd-k17953061-001-08-5

    83. Brd-k17953061-001-10-1

    84. Brd-k17953061-001-11-9

    85. (2s,3r,4r,6r)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one

    86. (2s,3r,4r,6r)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8,10,12,14(28),15(19),20(27),21,23,25-nonaen-16-one

    87. (2s,3r,4r,6r)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one

    88. (5s,6r,7r,9r)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5h,14h-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one

    89. (9s,10r,11r,13r)- 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1h,9h-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-1-one

    90. [9s-(9?,10?,11?,13?)]-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1h,9h-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one

    91. 109189-95-9

    92. 9,13-epoxy-1h,9h-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9s,10r,11r,13r)- & Tumor Necrosis Factor (tnf)

    93. 9,13-epoxy-1h,9h-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9s,10r,11r,13r)- (9ci)

    94. 9,13-epoxy-1h,9h-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9s-(9alpha,10beta,11beta,13alpha)]-

    2.4 Create Date
    2005-06-08
    3 Chemical and Physical Properties
    Molecular Weight 466.5 g/mol
    Molecular Formula C28H26N4O3
    XLogP33.2
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count2
    Exact Mass466.20049070 g/mol
    Monoisotopic Mass466.20049070 g/mol
    Topological Polar Surface Area69.4 Ų
    Heavy Atom Count35
    Formal Charge0
    Complexity901
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Enzyme Inhibitors

    Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)