Please Wait
Applying Filters...
Menu
Xls
2D Structure
Also known as: 61318-91-0, Exelderm, 82382-23-8, Sulconazole nitrate salt, 1-[2-(4-chlorobenzylthio)-2-(2,4-dichlorophenyl)ethyl]-1h-imidazole nitrate, Sulconazolenitrate
Molecular Formula
C18H16Cl3N3O3S
Molecular Weight
460.8  g/mol
InChI Key
CRKGMGQUHDNAPB-UHFFFAOYSA-N
FDA UNII
1T89100D5U

Sulconazole Nitrate is the nitrate salt form of sulconazole, a synthetic imidazole derivative with antifungal property. Sulconazole nitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to a disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. In addition, sulconazole nitrate seems to interfere with the autolytic degradation of fungal DNA and RNA.
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid
2.1.2 InChI
InChI=1S/C18H15Cl3N2S.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
2.1.3 InChI Key
CRKGMGQUHDNAPB-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC(=CC=C1CSC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl.[N+](=O)(O)[O-]
2.2 Other Identifiers
2.2.1 UNII
1T89100D5U
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-(beta-(4''-chlorobenzylthio)-2'4'-dichlorophenethyl)imidazole

2. Exelderm

3. Myk

4. Sulconazole

5. Sulconazole Mononitrate

6. Sulconazole, Mononitrate, (+-)-isomer

2.3.2 Depositor-Supplied Synonyms

1. 61318-91-0

2. Exelderm

3. 82382-23-8

4. Sulconazole Nitrate Salt

5. 1-[2-(4-chlorobenzylthio)-2-(2,4-dichlorophenyl)ethyl]-1h-imidazole Nitrate

6. Sulconazolenitrate

7. Sulconazole (mononitrate)

8. Sulcosyn

9. Rs 44872

10. Rs-44872

11. Sulconazole (nitrate)

12. 1-(2-((4-chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethyl)-1h-imidazole Nitrate

13. Nsc-757849

14. Rs-44872-00-10-3

15. 1-[2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric Acid

16. Mls000028611

17. (+/-)-sulconazole (nitrate)

18. (+/-)-sulconazole (mononitrate)

19. 1-(2-[p-chlorobenzylthio]-2-[2,4-dichlorophenyl]ethyl)-1h-imidazole

20. Sulconazole Mononitrate

21. 1t89100d5u

22. 61318-91-0 (nitrate)

23. Smr000058734

24. Dsstox_cid_25490

25. Dsstox_rid_80911

26. Dsstox_gsid_45490

27. Sulconazle Nitrate

28. Sr-01000000237

29. Unii-1t89100d5u

30. 1-(2-(4-chlorobenzylthio)-2-(2,4-dichlorophenyl)ethyl)-1h-imidazole Nitrate

31. Exelderm (tn)

32. Prestwick_128

33. Mfcd00058163

34. Sulconazole Nitrate [usan:usp:jan]

35. Opera_id_1591

36. Ncgc00016898-01

37. (+-)-1-(2,4-dichloro-beta-((4-chlorobenzyl)thio)phenethyl)imidazole Nitrate

38. Sulconazole Nitrate (1:x)

39. Sulconazolenitratesalt

40. Cas-61318-91-0

41. (+-)-1-(2,4-dichloro-beta-((p-chlorobenzyl)thio)phenethyl)imidazole Mononitrate

42. Schembl36906

43. Mls001146948

44. Mls002222171

45. Spectrum1501148

46. Chebi:9326

47. Sulconazole Nitrate (jan/usp)

48. Chembl1200348

49. Dtxsid2045490

50. Sulconazole Nitrate [mi]

51. Hms500k22

52. Sulconazole Nitrate [jan]

53. Hms1570b21

54. Hms1921l03

55. Hms2092h09

56. Hms2097b21

57. Hms2232b18

58. Hms3370h17

59. Hms3652c18

60. Hms3714b21

61. Pharmakon1600-01501148

62. Sulconazole Nitrate [usan]

63. Sulconazole Nitrate [vandf]

64. Bcp15962

65. Hy-b1460

66. Sulconazole Nitrate [mart.]

67. Tox21_110671

68. Ccg-39015

69. Nsc757849

70. S4120

71. Sulconazole Nitrate [usp-rs]

72. Sulconazole Nitrate [who-dd]

73. Akos015897482

74. Tox21_110671_1

75. Ks-1471

76. Nsc 757849

77. 1-[2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole; Nitric Acid

78. Ncgc00018250-06

79. Ncgc00094911-01

80. Ncgc00094911-02

81. Ncgc00094911-03

82. Ncgc00094911-04

83. Sulconazole Nitrate [orange Book]

84. 1h-imidazole, 1-(2-(((4-chlorophenyl)methyl)thio)-2-(2,4-dichlorophenyl)ethyl)-, Mononitrate, (+-)-

85. 1h-imidazole, 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-, Nitrate (9ci)

86. Ac-26451

87. Sulconazole Nitrate [usp Monograph]

88. Cs-0013167

89. Ft-0659334

90. Sw196439-3

91. U0112

92. D00886

93. Rs-44872-00-1o-3

94. A833159

95. A916203

96. Sr-01000000237-2

97. Sr-01000000237-4

98. Q27252867

99. (+/-)-1-(2,4-dichloro-.beta.-((p-chlorobenzyl)thio)phenethyl)imidazole Mononitrate

100. 1-[2-[(4-chlorophenyl)methylthio]-2-(2,4-dichlorophenyl)ethyl]imidazole; Nitric Acid

101. 1h-imidazole, 1-(2-(((4-chlorophenyl)methyl)thio)-2-(2,4-dichlorophenyl)ethyl)-, Mononitrate, (+/-)-

102. 1h-imidazole, 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-, Nitrate (1:1)

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 460.8 g/mol
Molecular Formula C18H16Cl3N3O3S
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass458.997796 g/mol
Monoisotopic Mass458.997796 g/mol
Topological Polar Surface Area109 Ų
Heavy Atom Count28
Formal Charge0
Complexity404
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameExelderm
PubMed HealthSulconazole (Topical route)
Drug ClassesAntifungal, Imidazole
Drug LabelEXELDERM (sulconazole nitrate, USP) CREAM, 1.0% is a broad-spectrum antifungal agent intended for topical application. Sulconazole nitrate, USP the active ingredient in EXELDERM CREAM, is an imidazole derivative with in vitro antifungal and antiyeast...
Active IngredientSulconazole nitrate
Dosage FormCream; Solution
RouteTopical
Strength1%
Market StatusPrescription
CompanyRanbaxy

2 of 2  
Drug NameExelderm
PubMed HealthSulconazole (Topical route)
Drug ClassesAntifungal, Imidazole
Drug LabelEXELDERM (sulconazole nitrate, USP) CREAM, 1.0% is a broad-spectrum antifungal agent intended for topical application. Sulconazole nitrate, USP the active ingredient in EXELDERM CREAM, is an imidazole derivative with in vitro antifungal and antiyeast...
Active IngredientSulconazole nitrate
Dosage FormCream; Solution
RouteTopical
Strength1%
Market StatusPrescription
CompanyRanbaxy

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Azoles [CS]; Azole Antifungal [EPC]