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    Sultopride

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    GLOBAL SALES INFORMATION

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    2D Structure
    Also known as: 53583-79-2, Barnetil, Topral, Lin 1418, Sultopridum [inn-latin], Lin-1418
    Molecular Formula
    C17H26N2O4S
    Molecular Weight
    354.5  g/mol
    InChI Key
    UNRHXEPDKXPRTM-UHFFFAOYSA-N
    FDA UNII
    AA0G3TW31W
    A benzamide derivative that is used as an antipsychotic agent for the treatment of schizophrenia. It is also used as an antidepressive agent.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide
    2.1.2 InChI
    InChI=1S/C17H26N2O4S/c1-4-19-10-6-7-13(19)12-18-17(20)15-11-14(24(21,22)5-2)8-9-16(15)23-3/h8-9,11,13H,4-7,10,12H2,1-3H3,(H,18,20)
    2.1.3 InChI Key
    UNRHXEPDKXPRTM-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)CC)OC
    2.2 Other Identifiers
    2.2.1 UNII
    AA0G3TW31W
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 4-amino-n-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

    2. Amisulpride

    3. Barnetil

    4. Dan 2163

    5. Dan-2163

    6. Lin 1418

    7. Lin-1418

    8. N-(ethyl-1-pyrrolidinyl- 2-methyl)methoxy-2-ethylsulfonyl-5-benzamide

    9. Solian

    10. Sultopride Hydrochloride

    2.3.2 Depositor-Supplied Synonyms

    1. 53583-79-2

    2. Barnetil

    3. Topral

    4. Lin 1418

    5. Sultopridum [inn-latin]

    6. Lin-1418

    7. Aa0g3tw31w

    8. Chebi:9356

    9. N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-o-anisamide

    10. Sultopride (inn)

    11. Barnotil

    12. Benzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxy-

    13. Sultopride [inn]

    14. Sultopridum

    15. Sultroprida

    16. Sultopride [inn:dcf]

    17. N-((1-ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

    18. N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxy-benzamide

    19. Sultroprida [inn-spanish]

    20. (+/-)-sultopride

    21. Ncgc00185771-01

    22. Einecs 258-641-9

    23. Unii-aa0g3tw31w

    24. Brn 0494772

    25. Sultopride [mi]

    26. Sultopride [who-dd]

    27. 5-22-08-00103 (beilstein Handbook Reference)

    28. Schembl149197

    29. Chembl277945

    30. Dtxsid9023627

    31. Bdbm86720

    32. Nsc_5357

    33. N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide

    34. Pdsp1_001575

    35. Pdsp2_001559

    36. Akos024255726

    37. O-anisamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-

    38. Db13273

    39. Ks-5337

    40. Hy-42849

    41. Cas_53583-79-2

    42. Db-071706

    43. Cs-0040602

    44. Ft-0725190

    45. D08549

    46. L001065

    47. Q4445779

    48. (+/-)-n-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

    49. N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

    50. N-[(1-ethylpyrrolidin-2-yl)methyl]-5-(ethylsulfonyl)-2-(methyloxy)benzamide

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 354.5 g/mol
    Molecular Formula C17H26N2O4S
    XLogP31.6
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count7
    Exact Mass354.16132849 g/mol
    Monoisotopic Mass354.16132849 g/mol
    Topological Polar Surface Area84.1 Ų
    Heavy Atom Count24
    Formal Charge0
    Complexity517
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antidepressive Agents, Second-Generation

    A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake. (See all compounds classified as Antidepressive Agents, Second-Generation.)

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

    Dopamine Antagonists

    Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

    4.2 ATC Code

    N - Nervous system

    N05 - Psycholeptics

    N05A - Antipsychotics

    N05AL - Benzamides

    N05AL02 - Sultopride