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    Suxibuzone

    ACTIVE PHARMA INGREDIENTS

    MARKET PLACE

    PharmaCompass
    Xls

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    2D Structure
    Also known as: 27470-51-5, Calibene, Suxibuzona, Suxibuzonum, Solurol, Flogos
    Molecular Formula
    C24H26N2O6
    Molecular Weight
    438.5  g/mol
    InChI Key
    ONWXNHPOAGOMTG-UHFFFAOYSA-N
    FDA UNII
    86TDZ5WP2B
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-[(4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)methoxy]-4-oxobutanoic acid
    2.1.2 InChI
    InChI=1S/C24H26N2O6/c1-2-3-16-24(17-32-21(29)15-14-20(27)28)22(30)25(18-10-6-4-7-11-18)26(23(24)31)19-12-8-5-9-13-19/h4-13H,2-3,14-17H2,1H3,(H,27,28)
    2.1.3 InChI Key
    ONWXNHPOAGOMTG-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCCCC1(C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3)COC(=O)CCC(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    86TDZ5WP2B
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1,2-diphenyl-4-n-butyl-4-hydroxymethyl-3,5-dioxopyrazolidine Hemisuccinate

    2. 4-butyl-4-(beta-carboxypropionyloxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione

    2.3.2 Depositor-Supplied Synonyms

    1. 27470-51-5

    2. Calibene

    3. Suxibuzona

    4. Suxibuzonum

    5. Solurol

    6. Flogos

    7. 4-hydroxymethylbutazolidine Hemisuccinate

    8. 4-((4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)methoxy)-4-oxobutanoic Acid

    9. Ae-17

    10. 4-butyl-4-hydroxymethyl-1,2-diphenyl-3,5-pyrazolidinedione Hydrogen Succinate

    11. 4-[(4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)methoxy]-4-oxobutanoic Acid

    12. Chebi:32173

    13. Nsc-757866

    14. 86tdz5wp2b

    15. 4-butyl-4-(hydroxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione Hydrogen Succinate (ester)

    16. Succinic Acid, Monoester With 4-butyl-4-(hydroxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione

    17. Ncgc00016799-01

    18. Aflogan

    19. Flamilon

    20. Alfide

    21. Cas-27470-51-5

    22. Dsstox_cid_1296

    23. 3,5-pyrazolidinedione, 4-butyl-4-(hydroxymethyl)-1,2-diphenyl-, Hydrogen Succinate (ester)

    24. Dsstox_rid_76066

    25. Dsstox_gsid_21296

    26. Suxibuzonum [inn-latin]

    27. Suxibuzona [inn-spanish]

    28. Butanedioic Acid, Mono((4-butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methyl) Ester

    29. Butanedioic Acid, Mono[(4-butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methyl] Ester

    30. 4-butyl-4-[hydroxymethyl]-1,2-diphenyl-3,5-pyrazolidinedione Hydrogen Succinate [ester]

    31. Ae 17

    32. Sr-01000841241

    33. Einecs 248-477-6

    34. Unii-86tdz5wp2b

    35. Brn 0904563

    36. Suxibuzon

    37. Suxibuzone [inn:ban:jan]

    38. Prestwick_113

    39. Spectrum_000321

    40. Suxibuzone (jan/inn)

    41. Suxibuzone [inn]

    42. Suxibuzone [jan]

    43. Prestwick0_000658

    44. Prestwick1_000658

    45. Prestwick2_000658

    46. Prestwick3_000658

    47. Spectrum2_000966

    48. Spectrum3_000664

    49. Spectrum4_000433

    50. Spectrum5_001113

    51. Epitope Id:124941

    52. 4-butyl-4-(beta-carboxypropionyl-oxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione

    53. Suxibuzone [mart.]

    54. 3-((4-butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methoxycarbonyl)propionsaeure

    55. Suxibuzone [who-dd]

    56. Schembl25810

    57. Bspbio_000695

    58. Bspbio_002327

    59. Kbiogr_000786

    60. Kbioss_000801

    61. Mls002153938

    62. Divk1c_000171

    63. Spectrum1501157

    64. Spbio_000971

    65. Spbio_002616

    66. Bpbio1_000765

    67. Chembl1414320

    68. Dtxsid6021296

    69. Suxibuzone [ep Impurity]

    70. Hms500i13

    71. Kbio1_000171

    72. Kbio2_000801

    73. Kbio2_003369

    74. Kbio2_005937

    75. Kbio3_001547

    76. Brd5826

    77. Suxibuzone [ep Monograph]

    78. Ninds_000171

    79. Hms1570c17

    80. Hms1923i17

    81. Hms2097c17

    82. Hms2232e17

    83. Hms3371a12

    84. Hms3714c17

    85. Pharmakon1600-01501157

    86. Brd-5826

    87. Hy-b1079

    88. Zinc3875039

    89. Tox21_110615

    90. Tox21_202352

    91. Tox21_302778

    92. Ccg-40180

    93. Nsc757866

    94. Akos024374988

    95. Tox21_110615_1

    96. Cs-4635

    97. Db13232

    98. Nsc 757866

    99. 4-[(4-butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methoxy]-4-oxobutanoic Acid

    100. 4-{[(4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)methyl]oxy}-4-oxobutanoic Acid

    101. 4-butyl-4-[hydroxymethyl]-1,2-diphenyl-3,5-pyrazolidinedionehydrogensuccinate[ester]

    102. Idi1_000171

    103. Ncgc00016799-02

    104. Ncgc00016799-03

    105. Ncgc00016799-04

    106. Ncgc00016799-05

    107. Ncgc00016799-06

    108. Ncgc00016799-08

    109. Ncgc00095261-01

    110. Ncgc00095261-02

    111. Ncgc00095261-03

    112. Ncgc00095261-04

    113. Ncgc00256470-01

    114. Ncgc00259901-01

    115. Smr001233279

    116. Sbi-0051667.p002

    117. Db-047228

    118. Ab00052229

    119. Ft-0630533

    120. D01289

    121. Ab00052229_08

    122. Ab00052229_09

    123. 470s515

    124. A936730

    125. J-016775

    126. Q7650623

    127. Sr-01000841241-2

    128. Sr-01000841241-3

    129. Brd-k78815826-001-05-4

    130. Brd-k78815826-001-08-8

    131. Suxibuzone, European Pharmacopoeia (ep) Reference Standard

    132. 4-butyl-4-(.beta.-carboxypropionyl-oxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 438.5 g/mol
    Molecular Formula C24H26N2O6
    XLogP33.6
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count11
    Exact Mass438.17908655 g/mol
    Monoisotopic Mass438.17908655 g/mol
    Topological Polar Surface Area104 Ų
    Heavy Atom Count32
    Formal Charge0
    Complexity661
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents, Non-Steroidal

    Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

    4.2 ATC Code

    M - Musculo-skeletal system

    M02 - Topical products for joint and muscular pain

    M02A - Topical products for joint and muscular pain

    M02AA - Antiinflammatory preparations, non-steroids for topical use

    M02AA22 - Suxibuzone