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    Tamsulosin Hydrochloride

    ACTIVE PHARMA INGREDIENTS

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    2D Structure
    Also known as: 106463-17-6, Flomax, Tamsulosin hcl, Omnic, Pradif, Harnal
    Molecular Formula
    C20H29ClN2O5S
    Molecular Weight
    445.0  g/mol
    InChI Key
    ZZIZZTHXZRDOFM-XFULWGLBSA-N
    FDA UNII
    11SV1951MR
    A sulfonamide derivative and adrenergic alpha-1 receptor antagonist that is used to relieve symptoms of urinary obstruction caused by BENIGN PROSTATIC HYPERPLASIA.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide;hydrochloride
    2.1.2 InChI
    InChI=1S/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H/t15-;/m1./s1
    2.1.3 InChI Key
    ZZIZZTHXZRDOFM-XFULWGLBSA-N
    2.1.4 Canonical SMILES
    CCOC1=CC=CC=C1OCCNC(C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N.Cl
    2.1.5 Isomeric SMILES
    CCOC1=CC=CC=C1OCCN[C@H](C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    11SV1951MR
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide

    2. Flomax

    3. Ly 253352

    4. Ly-253352

    5. Tamsulosin

    6. Ym 617

    7. Ym-617

    2.3.2 Depositor-Supplied Synonyms

    1. 106463-17-6

    2. Flomax

    3. Tamsulosin Hcl

    4. Omnic

    5. Pradif

    6. Harnal

    7. Urolosin

    8. Secotex

    9. Josir

    10. Alna

    11. Omic

    12. Omix

    13. Ym617

    14. Ly253351

    15. Amsulosin Hydrochloride

    16. Tamsulosin (hydrochloride)

    17. (r)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide Hydrochloride

    18. R-(-)-ym-12617

    19. Ym 617

    20. Ym-12617-1

    21. Ym-617

    22. Ly-253351

    23. Chebi:9399

    24. (-)-(r)-5-(2-((2-(o-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide Monohydrochloride

    25. 11sv1951mr

    26. 5-[(2r)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide Hydrochloride

    27. 5-[(2r)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide;hydrochloride

    28. 5-[(r)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]]-2-methoxybenzenesulfonamide Hydrochloride

    29. R-(-)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide Hydrochloride

    30. Expros

    31. Flomax (tn)

    32. Dsstox_cid_26628

    33. Dsstox_rid_81777

    34. Dsstox_gsid_46628

    35. 128332-25-2

    36. Benzenesulfonamide, 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxy-, Monohydrochloride, (r)-

    37. (r)-5-(2-(2-(2-ethoxyphenoxy)ethylamino)propyl)-2-methoxybenzenesulfonamide Hydrochloride

    38. (-)-(r)-5-(2-((2-(o-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzene Sulfonamide Monohydrochloride

    39. Cas-106463-17-6

    40. Tamsulosine Hydrochloride

    41. Ncgc00167442-01

    42. Mfcd00922997

    43. (r)-tamsulosin Hydrochloride

    44. Unii-11sv1951mr

    45. Tamsulosin.hcl

    46. Harnalidge Ocas

    47. Flomax Mr

    48. Alnaocas

    49. 5-[(2r)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzenesulfonamide Hydrochloride

    50. Flomax Hydrochloride

    51. Harnal (tn)

    52. Tamsulosin Hydrochloride [usan:usp:jan]

    53. Tamsulosina Hydrochloride

    54. Tamsulosinum Hydrochloride

    55. (-)-ly 253352

    56. Schembl23428

    57. Tamsulosin Hydrochloride,(s)

    58. Mls003899197

    59. Racemic Tamsulosin Hydrochloride

    60. Chembl1200914

    61. Dtxsid2046628

    62. Hy-b0661a

    63. 5-[(2rs)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide Hydrochloride (tamsulosin Racemate Hydrochloride)

    64. Tox21_112446

    65. Eu-617

    66. S4729

    67. (r)-tamsulosin Hydrochloride- Bio-x

    68. Tamsulosin Hydrochloride (jp17/usp)

    69. Tamsulosin Hydrochloride [jan]

    70. Akos015895342

    71. Akos015995287

    72. Tox21_112446_1

    73. Bs-1019

    74. Ccg-269178

    75. Tamsulosin Hydrochloride [usan]

    76. (-)-ly253352

    77. Tamsulosin Hydrochloride [mart.]

    78. Tamsulosin Hydrochloride [vandf]

    79. Ncgc00167442-03

    80. Tamsulosin Hydrochloride [usp-rs]

    81. Tamsulosin Hydrochloride [who-dd]

    82. Bt164440

    83. Smr002543366

    84. Bcp0726000042

    85. Tamsulosin Hydrochloride, >=98% (hplc)

    86. T2749

    87. Y-617

    88. Tamsulosin Hydrochloride [orange Book]

    89. A14936

    90. D01024

    91. Jalyn Component Tamsulosin Hydrochloride

    92. Tamsulosin Hydrochloride [ep Monograph]

    93. Tamsulosin Hydrochloride [usp Impurity]

    94. Tamsulosin Hydrochloride [usp Monograph]

    95. 463t176

    96. A801444

    97. Tamsulosin Hydrochloride Component Of Jalyn

    98. Q-201777

    99. (r)-(-)-ym12617;ly253351

    100. (r)-5-(2-(2-(2-ethoxyphenoxy)ethylamino)propyl)-2

    101. Q27108379

    102. Tamsulosin Hydrochloride, British Pharmacopoeia (bp) Reference Standard

    103. Tamsulosin Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    104. (r)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide Hcl

    105. 5-((2r)-2-(2-(2-ethoxyphenoxy)ethylamino)propyl)-2-methoxybenzene-sulfonamide Hcl

    106. 5-[(r)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]]-2-methoxybenzenesulfonamidehydrochloride

    107. Tamsulosin Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    108. Tamsulosin Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    109. (r)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide Monohydrochloride

    110. 5-[(2r)-2-[[2-(-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide Hydrochloride;tamsulosin Hcl

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 445.0 g/mol
    Molecular Formula C20H29ClN2O5S
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count11
    Exact Mass444.1485709 g/mol
    Monoisotopic Mass444.1485709 g/mol
    Topological Polar Surface Area108 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity539
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameFlomax
    PubMed HealthTamsulosin (By mouth)
    Drug ClassesBenign Prostatic Hypertrophy Agent
    Drug LabelTamsulosin hydrochloride is an antagonist of alpha1A adrenoceptors in the prostate.Tamsulosin hydrochloride is (-)-(R)-5-[2-[[2-(o-Ethoxyphenoxy) ethyl]amino]propyl]-2-methoxybenzenesulfonamide, monohydrochloride. Tamsulosin hydrochloride is a white...
    Active IngredientTamsulosin hydrochloride
    Dosage FormCapsule
    RouteOral
    Strength0.4mg
    Market StatusPrescription
    CompanyBoehringer Ingelheim

    2 of 4  
    Drug NameTamsulosin hydrochloride
    Drug LabelTamsulosin hydrochloride is an antagonist of alpha1A adrenoceptors in the prostate.Tamsulosin hydrochloride is (-)-(R)-5-[2-[[2-(o-Ethoxyphenoxy) ethyl]amino]propyl]-2-methoxybenzenesulfonamide, monohydrochloride. Tamsulosin hydrochloride is a white...
    Active IngredientTamsulosin hydrochloride
    Dosage FormCapsule
    Routeoral; Oral
    Strength0.4mg
    Market StatusTentative Approval; Prescription
    CompanySynthon Pharms; Anchen Pharms; Wockhardt; Ranbaxy; Aurobindo Pharma; Sun Pharm Inds; Sandoz; Teva Pharms; Zydus Pharms Usa; Mylan; Impax Labs

    3 of 4  
    Drug NameFlomax
    PubMed HealthTamsulosin (By mouth)
    Drug ClassesBenign Prostatic Hypertrophy Agent
    Drug LabelTamsulosin hydrochloride is an antagonist of alpha1A adrenoceptors in the prostate.Tamsulosin hydrochloride is (-)-(R)-5-[2-[[2-(o-Ethoxyphenoxy) ethyl]amino]propyl]-2-methoxybenzenesulfonamide, monohydrochloride. Tamsulosin hydrochloride is a white...
    Active IngredientTamsulosin hydrochloride
    Dosage FormCapsule
    RouteOral
    Strength0.4mg
    Market StatusPrescription
    CompanyBoehringer Ingelheim

    4 of 4  
    Drug NameTamsulosin hydrochloride
    Drug LabelTamsulosin hydrochloride is an antagonist of alpha1A adrenoceptors in the prostate.Tamsulosin hydrochloride is (-)-(R)-5-[2-[[2-(o-Ethoxyphenoxy) ethyl]amino]propyl]-2-methoxybenzenesulfonamide, monohydrochloride. Tamsulosin hydrochloride is a white...
    Active IngredientTamsulosin hydrochloride
    Dosage FormCapsule
    Routeoral; Oral
    Strength0.4mg
    Market StatusTentative Approval; Prescription
    CompanySynthon Pharms; Anchen Pharms; Wockhardt; Ranbaxy; Aurobindo Pharma; Sun Pharm Inds; Sandoz; Teva Pharms; Zydus Pharms Usa; Mylan; Impax Labs

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Urological Agents

    Drugs used in the treatment of urological conditions and diseases such as URINARY INCONTINENCE and URINARY TRACT INFECTIONS. (See all compounds classified as Urological Agents.)

    Adrenergic alpha-1 Receptor Antagonists

    Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Antagonists.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    alpha-Adrenergic Blocker [EPC]; Adrenergic alpha-Antagonists [MoA]