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    Tc-99m-tetrofosmin

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    2D Structure
    Also known as: Technetium tc-99m tetrofosmin, Q7692231
    Molecular Formula
    C18H40O4P2Tc
    Molecular Weight
    479.4  g/mol
    InChI Key
    BDMZPZIFZPWFFW-UHFFFAOYSA-N
    Technetium Tc-99m Tetrofosmin is a radiopharmaceutical consisting of tetrofosmin, composed of two bidentate diphosphine ligands chelating the metastable radioisotope technetium Tc-99 (99mTc), with potential imaging activity upon SPECT (single photon emission computed tomography). Upon administration, technetium Tc 99m tetrofosmin is preferentially taken up by, and accumulates in, myocardial cells. Upon imaging, myocardial cells can be visualized and changes in ischemia and/or perfusion can be detected.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[bis(2-ethoxyethyl)phosphanyl]ethyl-bis(2-ethoxyethyl)phosphane;technetium
    2.1.2 InChI
    InChI=1S/C18H40O4P2.Tc/c1-5-19-9-13-23(14-10-20-6-2)17-18-24(15-11-21-7-3)16-12-22-8-4;/h5-18H2,1-4H3;
    2.1.3 InChI Key
    BDMZPZIFZPWFFW-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCOCCP(CCOCC)CCP(CCOCC)CCOCC.[Tc]
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. 99mtc-tetrafosmin

    2. 99mtc-tetrofosmin

    3. Myoview

    4. Ppn-1011

    5. Ppn1011

    6. Tc-99m-ppn1011

    7. Tc-99m-tetrofosmin

    8. Technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane

    9. Technetium Tc-99m Tetrofosmin

    10. Technetium(1+)-99tc, Bis(6,9-bis(2-ethoxyethyl)-3,12-dioxa-6,9-diphosphatetradecane-.kappa.p,.kappa.p')dioxo-, (oc-6-11)-

    11. Technetium-99m-tetrofosmin

    2.2.2 Depositor-Supplied Synonyms

    1. Technetium Tc-99m Tetrofosmin

    2. Q7692231

    2.3 Create Date
    2014-03-06
    3 Chemical and Physical Properties
    Molecular Weight 479.4 g/mol
    Molecular Formula C18H40O4P2Tc
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count19
    Exact Mass479.14654 g/mol
    Monoisotopic Mass479.14654 g/mol
    Topological Polar Surface Area36.9 Ų
    Heavy Atom Count25
    Formal Charge0
    Complexity201
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Radiopharmaceuticals

    Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161) (See all compounds classified as Radiopharmaceuticals.)