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    Tc-Choletec

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: Technetium tc 99m mebrofenin, Technetium tc-99m mebrofenin, Technetium (99mtc) mebrofenin, 1415247-71-0, 2-[[2-(3-bromo-2,4,6-trimethylanilino)-2-oxoethyl]-(carboxymethyl)amino]acetic acid;technetium-99, Mebrofenin / 99tc
    Molecular Formula
    C15H19BrN2O5Tc
    Molecular Weight
    486.13  g/mol
    InChI Key
    JLJSYHOPCNWUNE-IEOVAKBOSA-N
    FDA UNII
    F2NQ468L52
    Technetium Tc-99m Mebrofenin is a radioconjugate composed of the iminodiacetic acid derivative mebrofenin bound to an isotope of the synthetic element technetium (Tc). Upon administration and rapid clearance from the circulation, technetium Tc 99m mebrofenin is secreted into the hepatobiliary system, emitting gamma rays that are detectable with planar scintigraphy or single photon emission computer tomography (SPECT). Mebrofenin has no pharmacological effect at the recommended dosage for diagnostic imagining.
    Technetium tc-99m mebrofenin is a Radioactive Diagnostic Agent. The mechanism of action of technetium tc-99m mebrofenin is as a Radiopharmaceutical Activity.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[[2-(3-bromo-2,4,6-trimethylanilino)-2-oxoethyl]-(carboxymethyl)amino]acetic acid;technetium-99
    2.1.2 InChI
    InChI=1S/C15H19BrN2O5.Tc/c1-8-4-9(2)15(10(3)14(8)16)17-11(19)5-18(6-12(20)21)7-13(22)23;/h4H,5-7H2,1-3H3,(H,17,19)(H,20,21)(H,22,23);/i;1+1
    2.1.3 InChI Key
    JLJSYHOPCNWUNE-IEOVAKBOSA-N
    2.1.4 Canonical SMILES
    CC1=CC(=C(C(=C1NC(=O)CN(CC(=O)O)CC(=O)O)C)Br)C.[Tc]
    2.1.5 Isomeric SMILES
    CC1=CC(=C(C(=C1NC(=O)CN(CC(=O)O)CC(=O)O)C)Br)C.[99Tc]
    2.2 Other Identifiers
    2.2.1 UNII
    F2NQ468L52
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 99mtc Mebrofenin

    2. Bridatec

    3. Tc-99m-3-bromo-2,4,6-trimethyl-ida

    4. Tc-99m-3-bromo-2,4,6-trimethyliminodiacetic Acid

    5. Tc-99m-br-ida

    6. Tc-99m-brida

    7. Tc-99m-btm-ida

    8. Tc-99m-n-(2,4,6-trimethylbromoacetanilide)iminodiacetate

    9. Tc-99m-sq 26,962

    10. Tc-99m-tbida

    11. Tc-99m-trimethyl-brida

    12. Tc-99m-trimethylbromo-ida

    13. Tc-99m-trimethylbromoimino-diacetic Acid

    14. Tc-99m-trimethylbromoiminodiacetate

    15. Tc-choletec

    16. Tc-tmb-ida

    17. Technetium Tc 99m 3-bromo-2,4,6-trimethyliminodiacetic Acid

    18. Technetium Tc 99m Mebrofenin

    19. Technetium Tc 99m-trimethylbromo-ida

    2.3.2 Depositor-Supplied Synonyms

    1. Technetium Tc 99m Mebrofenin

    2. Technetium Tc-99m Mebrofenin

    3. Technetium (99mtc) Mebrofenin

    4. 1415247-71-0

    5. 2-[[2-(3-bromo-2,4,6-trimethylanilino)-2-oxoethyl]-(carboxymethyl)amino]acetic Acid;technetium-99

    6. Mebrofenin / 99tc

    7. Mebrofenin / Technetium-99tc

    8. 99mtc-mebrofenin

    9. Mebrofenin Mixture With Technetium-99tc

    10. Technetium Tc-99m Mebrofenin Kit

    11. Technetium Tc 99m Disida

    12. F2nq468l52

    13. Db09137

    14. Glycine, N-(2-((3-bromo-2,4,6-trimethylphenyl)amino)-2-oxoethyl)-n-(carboxymethyl)-, Technetium-99tc Salt

    15. Technetium Tc 99m Mebrofenin [usan]

    16. Technetium Tc 99m Mebrofenin [who-dd]

    17. Technetium Tc 99m Diisopropyl-iminodiacetic Acid

    18. Q7692227

    19. Technetium Tc 99m Mebrofenin [usp Impurity]

    20. Q22075852

    21. Bis(2-[[2-(3-bromo-2,4,6-trimethylanilino)-2-oxoethyl]-(carboxymethyl)amino]acetate) Technetium

    2.4 Create Date
    2006-10-26
    3 Chemical and Physical Properties
    Molecular Weight 486.13 g/mol
    Molecular Formula C15H19BrN2O5Tc
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count7
    Exact Mass484.95398 g/mol
    Monoisotopic Mass484.95398 g/mol
    Topological Polar Surface Area107 Ų
    Heavy Atom Count24
    Formal Charge0
    Complexity443
    Isotope Atom Count1
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Indication

    Technetium Tc 99m Mebrofenin is indicated as a hepatobiliary imaging agent.

    FDA Label

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Radiopharmaceuticals

    Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161) (See all compounds classified as Radiopharmaceuticals.)

    5.2 FDA Pharmacological Classification
    5.2.1 Active Moiety
    TECHNETIUM TC-99M MEBROFENIN
    5.2.2 FDA UNII
    F2NQ468L52
    5.2.3 Pharmacological Classes
    Mechanisms of Action [MoA] - Radiopharmaceutical Activity
    5.3 ATC Code

    V - Various

    V09 - Diagnostic radiopharmaceuticals

    V09D - Hepatic and reticulo endothelial system

    V09DA - Technetium (99mtc) compounds

    V09DA04 - Technetium (99mTc) mebrofenin

    5.4 Absorption, Distribution and Excretion

    Absorption

    Visualisation in the liver could be detected by 5 minutes and maximum liver uptake occurred at 11 minutes post-injection. Hepatic duct and gallbladder visualization occurred by 10 to 15 minutes and intestinal activity was visualized by 30 to 60 minutes in subjects with normal hepatobiliary function The mean percent injected dose remaining in the blood at 10 minutes was 17%.

    Route of Elimination

    The mean percent injected dose excreted in the urine during the first 3 hours was 1%.

    Clearance

    Following intravenous administration in normal subjects, Technetium Tc 99m Mebrofenin was rapidly cleared from the circulation.

    5.5 Biological Half-Life

    Technetium Tc 99m decays by isomeric transition with a physical half-life of 6.02 hours.

    5.6 Mechanism of Action

    Technetium Tc 99m Mebrofenin has no known pharmacologic activity at the recommended doses. It is used as a diagnostic agent as Technetium-99m decays by isomeric transition to technetium-99 through the release of a detectable gamma ray.