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    Technical details about Telapristone, learn more about the structure, uses, toxicity, action, side effects and more

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    Telapristone

    APIs // Active Pharmaceutical Ingredients

    PharmaCompass

    Symbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

    Metrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

    2D Structure
    1. Also known as: 198414-30-1, Telapristone [inn], 65703mv349, (8s,11r,13s,14s,17r)-11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(2-methoxyacetyl)-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]phenanthren-3-one, Unii-65703mv349, Telapristone [who-dd]
    Molecular Formula
    C29H37NO4
    Molecular Weight
    463.6  g/mol
    InChI Key
    BHERMCLNVOVDPU-DQFOBABISA-N
    FDA UNII
    65703MV349
    Telapristone is an orally available 21-substituted-19-nor-progestin and selective progesterone receptor modulator (SPRM), with potential anti-progesterone and antineoplastic activities. Upon oral administration, telapristone competitively binds to the progesterone receptor (PR) in progesterone-responsive tissue and inhibits PR-mediated gene expression. This interferes with progesterone activity in the reproductive system. As a result, this agent may suppress ovulation and inhibit proliferation of endometrial tissue. Also, this agent may prevent cell growth and induce apoptosis in estrogen receptor (ER) and PR-positive breast cancer cells through a reduction in progesterone levels, ER downregulation and a suppression of the expression of cyclin-dependent kinases (CDK) 2 and 4, ultimately leading to G1/S cell cycle arrest. Unlike some other SPRMs, this agent does not exert any estrogenic, androgenic, anti-estrogenic, and anti-androgenic activities.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (8S,11R,13S,14S,17R)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(2-methoxyacetyl)-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
    2.1.2 InChI
    InChI=1S/C29H37NO4/c1-28-16-24(18-5-8-20(9-6-18)30(2)3)27-22-12-10-21(31)15-19(22)7-11-23(27)25(28)13-14-29(28,33)26(32)17-34-4/h5-6,8-9,15,23-25,33H,7,10-14,16-17H2,1-4H3/t23-,24+,25-,28-,29-/m0/s1
    2.1.3 InChI Key
    BHERMCLNVOVDPU-DQFOBABISA-N
    2.1.4 Canonical SMILES
    CC12CC(C3=C4CCC(=O)C=C4CCC3C1CCC2(C(=O)COC)O)C5=CC=C(C=C5)N(C)C
    2.1.5 Isomeric SMILES
    C[C@]12C[C@@H](C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@@]2(C(=O)COC)O)C5=CC=C(C=C5)N(C)C
    2.2 Other Identifiers
    2.2.1 UNII
    65703MV349
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. 198414-30-1

    2. Telapristone [inn]

    3. 65703mv349

    4. (8s,11r,13s,14s,17r)-11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(2-methoxyacetyl)-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]phenanthren-3-one

    5. Unii-65703mv349

    6. Telapristone [who-dd]

    7. Schembl2168441

    8. Dtxsid00173586

    9. 11beta-(4-(dimethylamino)phenyl)-17-hydroxy-21-methoxy-19-norpregna-4,9-diene-3,20-dione

    10. 19-norpregna-4,9-diene-3,20-dione, 17-hydroxy-11-(4-(dimethylamino)phenyl)-21-methoxy-, (11beta)-

    11. Q27263837

    12. (8s,11r,13s,14s,17r)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(2-methoxyacetyl)-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

    13. 11.beta.-(4-(dimethylamino)phenyl)-17-hydroxy-21-methoxy-19-norpregna-4,9-diene-3,20-dione

    14. 19-norpregna-4,9-diene-3,20-dione, 17-hydroxy-11-(4-(dimethylamino)phenyl)-21-methoxy-, (11.beta.)-

    2.4 Create Date
    2007-12-05
    3 Chemical and Physical Properties
    Molecular Weight 463.6 g/mol
    Molecular Formula C29H37NO4
    XLogP32.8
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count5
    Exact Mass463.27225866 g/mol
    Monoisotopic Mass463.27225866 g/mol
    Topological Polar Surface Area66.8 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity911
    Isotope Atom Count0
    Defined Atom Stereocenter Count5
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
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