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2D Structure
Also known as: 63074-08-8, Terazosin hcl, Hytrin, Fosfomic, Zayasel, Blavin
Molecular Formula
C19H26ClN5O4
Molecular Weight
423.9  g/mol
InChI Key
IWSWDOUXSCRCKW-UHFFFAOYSA-N
FDA UNII
8QOP8Z9955

1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone;hydrochloride
2.1.2 InChI
InChI=1S/C19H25N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H
2.1.3 InChI Key
IWSWDOUXSCRCKW-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC.Cl
2.2 Other Identifiers
2.2.1 UNII
8QOP8Z9955
2.3 Synonyms
2.3.1 MeSH Synonyms

1. A 45975

2. Adecur

3. Apo-terazosin

4. Deflox

5. Dysalfa

6. Flotrin

7. Heitrin

8. Hytrin

9. Hytrin Bph

10. Hytrine

11. Magnurol

12. Novo-terazosin

13. Nu-terazosin

14. Pms-terazosin

15. Ratio-terazosin

16. Sutif

17. Tazusin

18. Terazoflo

19. Terazosin

20. Terazosin Azu

21. Terazosin Hexal

22. Terazosin Hydrochloride Anhydrous

23. Terazosin, Monohydrochloride, Dihydrate

24. Terazosina Alter

25. Terazosina Kern

26. Terazosina Qualix

27. Zayasel

2.3.2 Depositor-Supplied Synonyms

1. 63074-08-8

2. Terazosin Hcl

3. Hytrin

4. Fosfomic

5. Zayasel

6. Blavin

7. Terazosin Hydrochloride Anhydrous

8. Vasocard

9. (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone Hydrochloride

10. Flumarc

11. Mls000040261

12. Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)-, Monohydrochloride

13. Terazosin (hydrochloride)

14. 8qop8z9955

15. Terazocin Hydrochloride (anhydrous)

16. Smr000044015

17. Dsstox_cid_25493

18. Dsstox_rid_80913

19. Dsstox_gsid_45493

20. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine Hydrochloride

21. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)4-[(tetrahydro-2-furanyl)carbonyl]piperazine Hydrochloride

22. Abbott-45975 Anhydrous

23. Cas-63074-08-8

24. Sr-01000000197

25. Unii-8qop8z9955

26. Prestwick_146

27. Opera_id_398

28. Ncgc00016903-01

29. Schembl41545

30. Terazosin Hydrochloride,pharma

31. Mls001077301

32. Mls001305722

33. Chembl1256665

34. Dtxsid7045493

35. Hy-b0371f

36. Hms1570g04

37. Pharmakon1600-01505576

38. Bcp12795

39. Terazosin Hydrochloride [mi]

40. Tox21_110674

41. Mfcd00467965

42. Nsc759168

43. S4679

44. Akos007930686

45. Tox21_110674_1

46. Ac-2074

47. Ccg-220751

48. Lp01138

49. Ncgc00016026-10

50. Ncgc00094404-01

51. Ncgc00094404-02

52. Terazosin Hydrochloride, Anhydrous

53. Ds-11401

54. Db-018541

55. Cs-0013075

56. Eu-0101138

57. Ft-0605647

58. T2751

59. D11585

60. D70611

61. T 4680

62. Terazosin Hydrochloride, >=98% (tlc), Powder

63. 074t088

64. Terazosin Hydrochloride Anhydrous [who-dd]

65. Sr-01000000197-2

66. Sr-01000000197-4

67. Q27270906

68. Sr-01000000197-12

69. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)-piperazine Hydrochloride

70. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine Hydrochloride

71. 2[4-(tetrahydro-2-furoy1)piperazinyl]-4-amino-6,7-dimethoxyquinazoline Hydrochloride

72. 4-amino-6,7-dimethoxy-2-[4-(tetrahydro-2-furoyl)-1-piperazinyl]quinazoline Hydrochloride

73. (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanonehydrochloride

74. [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone;hydrochloride

75. [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone;hydron;chloride

76. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-piperazine Hydrochloride

77. Methanone, (4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl)(tetrahydro-2-furanyl)-, Hydrochloride (1:1)

78. Piperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, Monohydrochloride

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 423.9 g/mol
Molecular Formula C19H26ClN5O4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass423.1673320 g/mol
Monoisotopic Mass423.1673320 g/mol
Topological Polar Surface Area103 Ų
Heavy Atom Count29
Formal Charge0
Complexity544
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameTerazosin hydrochloride
Drug LabelTerazosin hydrochloride, an alpha-1-selective adrenoceptor blocking agent, is a quinazoline derivative represented by the following chemical name and structural formula: (RS)-Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furan...
Active IngredientTerazosin hydrochloride
Dosage FormCapsule
RouteOral
Strengtheq 5mg base; eq 2mg base; eq 1mg base; eq 10mg base
Market StatusPrescription
CompanyJubilant Cadista; Apotex; Sandoz; Ivax Sub Teva Pharms; Mylan

2 of 2  
Drug NameTerazosin hydrochloride
Drug LabelTerazosin hydrochloride, an alpha-1-selective adrenoceptor blocking agent, is a quinazoline derivative represented by the following chemical name and structural formula: (RS)-Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furan...
Active IngredientTerazosin hydrochloride
Dosage FormCapsule
RouteOral
Strengtheq 5mg base; eq 2mg base; eq 1mg base; eq 10mg base
Market StatusPrescription
CompanyJubilant Cadista; Apotex; Sandoz; Ivax Sub Teva Pharms; Mylan

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Urological Agents

Drugs used in the treatment of urological conditions and diseases such as URINARY INCONTINENCE and URINARY TRACT INFECTIONS. (See all compounds classified as Urological Agents.)


Adrenergic alpha-1 Receptor Antagonists

Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Antagonists.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
alpha-Adrenergic Blocker [EPC]; Adrenergic alpha-Antagonists [MoA]