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2D Structure
Also known as: Terbutaline solution, Terbutaline (sulfate), Mls000069693, Smr000058516, Kwd-2019, Sr-01000000174
Molecular Formula
C12H21NO7S
Molecular Weight
323.36  g/mol
InChI Key
MUPQZWGSBCWCAV-UHFFFAOYSA-N

A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol;sulfuric acid
2.1.2 InChI
InChI=1S/C12H19NO3.H2O4S/c1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)
2.1.3 InChI Key
MUPQZWGSBCWCAV-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)(C)NCC(C1=CC(=CC(=C1)O)O)O.OS(=O)(=O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Arubendol

2. Asthmoprotect

3. Brethaire

4. Brethine

5. Bricanyl

6. Bricanyl Sa

7. Butaliret

8. Butalitab

9. Contimit

10. Kwd 2019

11. Kwd-2019

12. Kwd2019

13. Monovent

14. Taziken

15. Tedipulmo

16. Terbasmin

17. Terbul

18. Terbutalin Al

19. Terbutalin Ratiopharm

20. Terbutalin Stada

21. Terbutalin Von Ct

22. Terbutalin-ratiopharm

23. Terbutaline

24. Terbutaline Sulfate

25. Terbuturmant

2.2.2 Depositor-Supplied Synonyms

1. Terbutaline Solution

2. Terbutaline (sulfate)

3. Mls000069693

4. Smr000058516

5. Kwd-2019

6. Sr-01000000174

7. Opera_id_498

8. Schembl41870

9. Mls001148384

10. Spectrum1500558

11. Chembl1160544

12. Regid_for_cid_657301

13. Hms500d20

14. Hms1921c15

15. Hms2092k19

16. Hms2231h10

17. Hms3259j05

18. Hms3372i16

19. Pharmakon1600-01500558

20. Ccg-39265

21. Nsc757336

22. Akos015960700

23. Nc00619

24. Ncgc00094789-01

25. Ncgc00094789-02

26. Ncgc00094789-03

27. Ncgc00094789-04

28. Ac-12158

29. Ac-33172

30. Vu0244552-7

31. Sr-01000000174-4

32. 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol,sulfuric Acid

2.3 Create Date
2005-06-29
3 Chemical and Physical Properties
Molecular Weight 323.36 g/mol
Molecular Formula C12H21NO7S
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass323.10387318 g/mol
Monoisotopic Mass323.10387318 g/mol
Topological Polar Surface Area156 Ų
Heavy Atom Count21
Formal Charge0
Complexity286
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameTerbutaline sulfate
Drug LabelTerbutaline Sulfate, USP, the active ingredient of Terbutaline Sulfate Injection, USP, is a betaadrenergic agonist bronchodilator available as a sterile, nonpyrogenic, aqueous solution in vials, for subcutaneous administration. Each milliliter of...
Active IngredientTerbutaline sulfate
Dosage FormTablet; Injectable
RouteInjection; Oral
Strength2.5mg; 1mg/ml; 5mg
Market StatusPrescription
CompanyBedford; Hikma Farmaceutica; United Biomedcl; Fresenius Kabi Usa; Lannett; Impax Labs; Akorn

2 of 2  
Drug NameTerbutaline sulfate
Drug LabelTerbutaline Sulfate, USP, the active ingredient of Terbutaline Sulfate Injection, USP, is a betaadrenergic agonist bronchodilator available as a sterile, nonpyrogenic, aqueous solution in vials, for subcutaneous administration. Each milliliter of...
Active IngredientTerbutaline sulfate
Dosage FormTablet; Injectable
RouteInjection; Oral
Strength2.5mg; 1mg/ml; 5mg
Market StatusPrescription
CompanyBedford; Hikma Farmaceutica; United Biomedcl; Fresenius Kabi Usa; Lannett; Impax Labs; Akorn

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Adrenergic beta-2 Receptor Agonists

Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS. (See all compounds classified as Adrenergic beta-2 Receptor Agonists.)


Bronchodilator Agents

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)


Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)


Tocolytic Agents

Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete. (See all compounds classified as Tocolytic Agents.)