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    Terevalefim

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    DIGITAL CONTENT

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    2D Structure
    Also known as: Terevalefim, Ang-3777, Terevalefim [inn], Terevalefim [usan], Snv-003, Gg91uxk2m5
    Molecular Formula
    C9H8N2S
    Molecular Weight
    176.24  g/mol
    InChI Key
    FOHWAQGURRYJFK-ONEGZZNKSA-N
    FDA UNII
    GG91UXK2M5
    Terevalefim is under investigation in clinical trial NCT02474667 (Reduce the Severity of DGF in Recipients of a Deceased Donor Kidney).
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5-[(E)-2-thiophen-2-ylethenyl]-1H-pyrazole
    2.1.2 InChI
    InChI=1S/C9H8N2S/c1-2-9(12-7-1)4-3-8-5-6-10-11-8/h1-7H,(H,10,11)/b4-3+
    2.1.3 InChI Key
    FOHWAQGURRYJFK-ONEGZZNKSA-N
    2.1.4 Canonical SMILES
    C1=CSC(=C1)C=CC2=CC=NN2
    2.1.5 Isomeric SMILES
    C1=CSC(=C1)/C=C/C2=CC=NN2
    2.2 Other Identifiers
    2.2.1 UNII
    GG91UXK2M5
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Ang-3777

    2. Snv-003

    3. Terevalefim

    2.3.2 Depositor-Supplied Synonyms

    1. Terevalefim

    2. Ang-3777

    3. Terevalefim [inn]

    4. Terevalefim [usan]

    5. Snv-003

    6. Gg91uxk2m5

    7. 1070881-42-3

    8. 500128-99-4

    9. 5-((e)-2-thiophen-2-yl-vinyl)-lh-pyrazole

    10. 1h-pyrazole, 3-((1e)-2-(2-thienyl)ethenyl)-

    11. Bb3

    12. Unii-gg91uxk2m5

    13. 5-[(e)-2-thiophen-2-ylethenyl]-1h-pyrazole

    14. Terevalefim [who-dd]

    15. Bb-3

    16. Schembl1225335

    17. Chembl4650326

    18. Schembl10149623

    19. Gtpl11997

    20. Ang3777

    21. Zinc4301780

    22. Who 11458

    23. 3-[2-(2-thienyl)ethenyl]-1h-pyrazole

    24. Hy-137455

    25. Cs-0138662

    26. (e)-5-(2-(thiophen-2-yl)vinyl)-1h-pyrazole

    27. E80357

    28. (e)-3-(2-(thiophen-2-yl)vinyl)-1h-pyrazole

    2.4 Create Date
    2005-07-19
    3 Chemical and Physical Properties
    Molecular Weight 176.24 g/mol
    Molecular Formula C9H8N2S
    XLogP32.2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count2
    Exact Mass176.04081944 g/mol
    Monoisotopic Mass176.04081944 g/mol
    Topological Polar Surface Area56.9 Ų
    Heavy Atom Count12
    Formal Charge0
    Complexity170
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 Mechanism of Action

    Terevalefim, a small molecule developed by Angion Biomedica Corp., mimics the activity of hepatocyte growth factor (HGF). Through its actions, it activates the c-Met cascade, exhibits c-Met dependence and c-Met receptor activation. As it is able to activate repair pathways, it has been tested in clinical trials for acute kidney injury and in delayed graft function. As of July 2020, Angion has announced a Phase 2 proof-of-concept trial to invesigate terevalefim on preventing and mitigating lung injury in patients with COVID-19 (NCT04459676).