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2D Structure
Also known as: Tetrachloroethene, 127-18-4, Perchloroethylene, Ethene, tetrachloro-, Perc, Perchlorethylene
Molecular Formula
C2Cl4
Molecular Weight
165.8  g/mol
InChI Key
CYTYCFOTNPOANT-UHFFFAOYSA-N
FDA UNII
TJ904HH8SN

A chlorinated hydrocarbon used as an industrial solvent and cooling liquid in electrical transformers. It is a potential carcinogen.
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1,1,2,2-tetrachloroethene
2.1.2 InChI
InChI=1S/C2Cl4/c3-1(4)2(5)6
2.1.3 InChI Key
CYTYCFOTNPOANT-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C(=C(Cl)Cl)(Cl)Cl
2.2 Other Identifiers
2.2.1 UNII
TJ904HH8SN
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Perchlorethylene

2. Perchloroethylene

3. Tetrachlorethylene

4. Tetrachloroethene

2.3.2 Depositor-Supplied Synonyms

1. Tetrachloroethene

2. 127-18-4

3. Perchloroethylene

4. Ethene, Tetrachloro-

5. Perc

6. Perchlorethylene

7. Tetrachlorethylene

8. 1,1,2,2-tetrachloroethylene

9. Ethylene Tetrachloride

10. Carbon Dichloride

11. Ankilostin

12. Didakene

13. Perclene

14. Tetracap

15. Tetraguer

16. Tetraleno

17. Tetralex

18. Tetropil

19. Perawin

20. Tetlen

21. Tetrachloraethen

22. Persec

23. Carbon Bichloride

24. Perk

25. Percloroetilene

26. Tetracloroetene

27. Fedal-un

28. 1,1,2,2-tetrachloroethene

29. Tetrachlooretheen

30. Czterochloroetylen

31. Percosolve

32. Perchlor

33. Perklone

34. Tetravec

35. Tetroguer

36. Nema

37. Perchloraethylen, Per

38. Perchlorethylene, Per

39. Perclene D

40. Dow-per

41. Dilatin Pt

42. Perchloorethyleen, Per

43. Antisol 1

44. Ethylene, Tetrachloro-

45. Perchloroethene

46. Antisal 1

47. Rcra Waste Number U210

48. Nema, Veterinary

49. Nci-c04580

50. Ent 1,860

51. Perclene Tg

52. Un 1897

53. Tj904hh8sn

54. Chebi:17300

55. Nsc-9777

56. Percosolv

57. Caswell No. 827

58. C2cl4

59. Mfcd00000834

60. Percloroetilene [italian]

61. Tetrachlooretheen [dutch]

62. Tetrachloraethen [german]

63. Tetracloroetene [italian]

64. Czterochloroetylen [polish]

65. Tetrachloroethylene (iupac)

66. Ccris 579

67. Hsdb 124

68. Perchloorethyleen, Per [dutch]

69. Perchloraethylen, Per [german]

70. Perchlorethylene, Per [french]

71. Tetrachloroethene 100 Microg/ml In Methanol

72. Tetrachloroethene 1000 Microg/ml In Methanol

73. Nsc 9777

74. Einecs 204-825-9

75. Un1897

76. Tetrachloroethylene [usp]

77. Rcra Waste No. U210

78. Unii-tj904hh8sn

79. Epa Pesticide Chemical Code 078501

80. Brn 1361721

81. Tetrachlorathen

82. Perchlorothylene

83. Ai3-01860

84. Tetrachloro-ethene

85. Ethene, 1,1,2,2-tetrachloro-

86. Tetrachloro-ethylene

87. Nema (van)

88. Wln: Gyguygg

89. Freon 1110

90. Tetrachlooretheen(dutch)

91. Tetrachloraethen(german)

92. Percloroetilene(italian)

93. Tetracloroetene(italian)

94. Dsstox_cid_1319

95. Bmse000633

96. Czterochloroetylen(polish)

97. Ec 204-825-9

98. 1,2,2-tetrachloroethylene

99. Dsstox_rid_76079

100. Dsstox_gsid_21319

101. Schembl23022

102. 4-01-00-00715 (beilstein Handbook Reference)

103. Bidd:er0346

104. 1,1,2,2-tetrachloro-ethene

105. Perchloorethyleen, Per(dutch)

106. Perchloraethylen, Per(german)

107. Perchlorethylene, Per(french)

108. Perchloroethylene Reagent Grade

109. Chembl114062

110. Tetrachloroethylene [ii]

111. Tetrachloroethylene [mi]

112. 1,1,2, 2-tetrachloroethylene

113. Dtxsid2021319

114. Tetrachloroethylene, >=99.5%

115. Nsc9777

116. Tetrachloroethylene [hsdb]

117. Tetrachloroethylene, Uv/ir-grade

118. Tetrachlorethylene [who-dd]

119. Tetrachloroethylene [mart.]

120. Zinc8214691

121. Tox21_201196

122. Akos009031593

123. Tetrachloroethylene, Analytical Standard

124. Tetrachloroethylene, Anhydrous, >=99%

125. Ncgc00090944-01

126. Ncgc00090944-02

127. Ncgc00090944-03

128. Ncgc00258748-01

129. Cas-127-18-4

130. Tetrachloroethylene [un1897] [poison]

131. Tetrachloroethylene, For Hplc, >=99.9%

132. Tetrachloroethylene, Reagentplus(r), 99%

133. Db-041854

134. Tetrachloroethylene, For Synthesis, 99.0%

135. Ft-0631739

136. Ft-0674946

137. S0641

138. Tetrachloroethylene, Acs Reagent, >=99.0%

139. En300-19890

140. Tetrachloroethene 5000 Microg/ml In Methanol

141. C06789

142. F 1110

143. 1,1,2,2-tetrachloroethylene (acd/name 4.0)

144. Tetrachloroethylene, Saj First Grade, >=98.0%

145. A805656

146. Q410772

147. Tetrachloroethylene, Saj Special Grade, >=99.0%

148. J-524851

149. Tetrachloroethylene, Uv Hplc Spectroscopic, 99.9%

150. Brd-k68386748-001-01-2

151. Tetrachloroethylene (perchloroethylene) [iarc]

152. F0001-0391

153. Tetrachloroethylene, Ultrapure, Spectrophotometric Grade

154. Density Standard 1623 Kg/m3, H&d Fitzgerald Ltd. Quality

155. 25135-99-3

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 165.8 g/mol
Molecular Formula C2Cl4
XLogP33.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count0
Exact Mass165.872461 g/mol
Monoisotopic Mass163.875411 g/mol
Topological Polar Surface Area0 Ų
Heavy Atom Count6
Formal Charge0
Complexity55.6
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

Anthelmintic (Nematodes, Trematodes)

O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 1704


VET: Anthelmintic.

O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 1704


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Carcinogens

Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. (See all compounds classified as Carcinogens.)


Environmental Pollutants

Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS. (See all compounds classified as Environmental Pollutants.)


Solvents

Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant and Hackh's Chemical Dictionary, 5th ed) (See all compounds classified as Solvents.)


5.2 Absorption, Distribution and Excretion

The mutagenicity of tetrachloroethene (tetra) and its S conjugate, S-(1,2,2-trichlorovinyl)glutathione (TCVG) was investigated using a modified Ames preincubation assay. TCVG was a potent mutagen in presence of rat kidney particulate fractions containing high concentrations of gamma-glutamyl transpeptidase (GGT) and dipeptidases. Purified tetra was not mutagenic without exogenous metabolic activation or under conditions favoring oxidative metabolism. Preincubation of tetra with purified rat liver glutathione (GSH) S-transferases in presence of GSH and rat kidney fractions resulted in a time-dependent formation of TCVG as determined by (HPLC) analysis and in an unequivocal mutagenic response in the Ames test. Experiments with tetra in the isolated perfused rat liver demonstrated TCVG formation and its excretion with the bile; bile collected after the addition of tetra to the isolated perfused liver was unequivocally mutagenic in bacteria in the presence of kidney particulate fractions. The mutagenicity was reduced in all cases by the GGT inhibitor serine borate or the beta-lyase inhibitor aminooxyacetic acid. These results support the suggestion that cleavage of the GSH S conjugate formed from tetra by the enzymes of the mercapturic acid pathway and by beta-lyase may be involved in the nephrocarcinogenic effects of this haloalkene in rats.

PMID:2671372 Vamvakas S et al; J Biochem Toxicol 4 (1): 21-7 (1989)


This article reports on the development of a "harmonized" PBPK model for the toxicokinetics of perchloroethylene (tetrachloroethylene or perc) in mice, rats, and humans that includes both oxidation and glutathione (GSH) conjugation of perc, the internal kinetics of the oxidative metabolite trichloroacetic acid (TCA), and the urinary excretion kinetics of the GSH conjugation metabolites N-Acetylated trichlorovinyl cysteine and dichloroacetic acid. The model utilizes a wider range of in vitro and in vivo data than any previous analysis alone, with in vitro data used for initial, or "baseline," parameter estimates, and in vivo datasets separated into those used for "calibration" and those used for "evaluation." Parameter calibration utilizes a limited Bayesian analysis involving flat priors and making inferences only using posterior modes obtained via Markov chain Monte Carlo (MCMC). As expected, the major route of elimination of absorbed perc is predicted to be exhalation as parent compound, with metabolism accounting for less than 20% of intake except in the case of mice exposed orally, in which metabolism is predicted to be slightly over 50% at lower exposures. In all three species, the concentration of perc in blood, the extent of perc oxidation, and the amount of TCA production is well-estimated, with residual uncertainties of approximately 2-fold. However, the resulting range of estimates for the amount of GSH conjugation is quite wide in humans (approximately 3000-fold) and mice (approximately 60-fold). While even high-end estimates of GSH conjugation in mice are lower than estimates of oxidation, in humans the estimated rates range from much lower to much higher than rates for perc oxidation. It is unclear to what extent this range reflects uncertainty, variability, or a combination. Importantly, by separating total perc metabolism into separate oxidative and conjugative pathways, an approach also recommended in a recent National Research Council review, this analysis reconciles the disparity between those previously published PBPK models that concluded low perc metabolism in humans and those that predicted high perc metabolism in humans. In essence, both conclusions are consistent with the data if augmented with some additional qualifications: in humans, oxidative metabolism is low, while GSH conjugation metabolism may be high or low, with uncertainty and/or interindividual variability spanning three orders of magnitude. More direct data on the internal kinetics of perc GSH conjugation, such as trichlorovinyl glutathione or tricholorvinyl cysteine in blood and/or tissues, would be needed to better characterize the uncertainty and variability in GSH conjugation in humans.

PMID:21466818 Chiu WA, Ginsberg GL; Toxicol Appl Pharmacol 253 (3): 203-34


Tetrachloroethylene is a volatile, lipophilic small molecule that is rapidly and extensively absorbed after inhalation and oral exposure. It can also be rapidly absorbed through the skin, but dermal absorption appears to be a less important route of exposure. In humans, inhalation exposure to tetrachloroethylene typically results, within a few hours of exposure, in a pseudoequilibrium between inspired air and blood although there can be substantial interindividual differences in absorption behavior. After oral dosing in animals, peak blood tetrachloroethylene concentrations are typically reached within 15-30 min, and systemic bioavailability is typically greater than 80%; once absorbed, tetrachloroethylene is rapidly distributed throughout the body, and well-perfused tissues reach a pseudoequilibrium with blood within a few minutes.

Committee to Review EPA's Toxicological Assessment of Tetrachloroethylene, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies; Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene. 186 pp. (2010). The National Academies Press, 500 Fifth Street, NW Washington, DC 20001. Available from, as of March 22, 2018: https://www.nap.edu/catalog/12863.html


Because of its lipophilicity, the highest concentrations of tetrachloroethylene are found in adipose tissue. In humans, the fat-to-blood concentration ratio has been estimated to be as high as 90:1. Relatively high concentrations are also observed in the liver and brain. On the basis of animal studies and sparse human data, the brain concentration of tetrachloroethylene is 4-8 times the blood concentration.

Committee to Review EPA's Toxicological Assessment of Tetrachloroethylene, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies; Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene. 186 pp. (2010). The National Academies Press, 500 Fifth Street, NW Washington, DC 20001. Available from, as of March 22, 2018: https://www.nap.edu/catalog/12863.html


For more Absorption, Distribution and Excretion (Complete) data for Tetrachloroethylene (32 total), please visit the HSDB record page.


5.3 Metabolism/Metabolites

Despite the low overall metabolism of tetrachloroethylene compared with other chlorinated solvents, its metabolism has been studied extensively in both human volunteers and laboratory animals, using both in vivo and in vitro techniques. The studies showed that many metabolites are produced, including some known to be cytotoxic, mutagenic or both. Tetrachloroethylene metabolism can be viewed as having three pathways. The first is cytochrome P-450-mediated (CYP-mediated) oxidation. The second and third share a starting point: direct conjugation with glutathione to S-(1,2,2-trichlorovinyl)glutathione (TCVG) and then further processing to S-(1,2,2-trichlorovinyl)-L-cysteine (TCVC). For the second pathway, beta-lyase catalyzes the formation of reactive products from TCVC. The third pathway is independent of beta-lyase: TCVC is processed further by acetylation and sulfoxidation reactions. Genotoxic and cytotoxic metabolites are formed by each of these pathways. The predominant metabolic pathway is the CYP path, followed by the beta-lyase pathway and then the beta-lyase independent pathway. The TCVC derivatives are toxicologically important but quantitatively minor metabolites.

Committee to Review EPA's Toxicological Assessment of Tetrachloroethylene, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies; Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene. 186 pp. (2010). The National Academies Press, 500 Fifth Street, NW Washington, DC 20001. Available from, as of March 22, 2018: https://www.nap.edu/catalog/12863.html


Trichloroethylene (TRI) and tetrachloroethylene (TETRA) are solvents that have been widely used in a variety of industries, and both are widespread environmental contaminants. ... Seven human volunteers were exposed by inhalation to 1 ppm of TRI or TETRA for 6 hr, with biological samples collected for analysis during exposure and up to 6 days postexposure. Concentrations of TRI, TETRA, free trichloroethanol (TCOH), total TCOH (free TCOH plus glucuronidated TCOH), and trichloroacetic acid (TCA) were determined in blood and urine; TRI and TETRA concentrations were measured in alveolar breath. Toxicokinetic time courses and empirical analyses of classical toxicokinetic parameters were compared with those reported in previous human volunteer studies, most of which involved exposures that were at least 10 fold higher. Qualitatively, TRI and TETRA toxicokinetics were consistent with previous human studies. Quantitatively, alveolar retention and clearance by exhalation were similar to those found previously but blood and urine data suggest a number of possible toxicokinetic differences. For TRI, data from the current study support lower apparent blood-air partition coefficients, greater apparent metabolic clearance, less TCA production, and greater glucuronidation of TCOH as compared to previous studies. For TETRA, the current data suggest TCA formation that is similar or slightly lower than that of previous studies. Variability and uncertainty in empirical estimates of total TETRA metabolism are substantial, with confidence intervals among different studies substantially overlapping. ...

PMID:17032701 Chiu WA et al; Toxicol Sci 95 (1): 23-36 (2007)


The two major products of tetrachloroethylene metabolism by the CYP pathway are trichloroacetyl chloride and oxalyl chloride.

Committee to Review EPA's Toxicological Assessment of Tetrachloroethylene, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies; Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene. 186 pp. (2010). The National Academies Press, 500 Fifth Street, NW Washington, DC 20001. Available from, as of March 22, 2018: https://www.nap.edu/catalog/12863.html


The beta-lyase pathway: Tetrachloroethylene is conjugated with glutathione to S-(1,2,2-trichlorovinyl) glutathione and is later processed by gamma-glutamyl transpeptidase and aminopeptidase to S-(1,2,2-trichlorovinyl)-L-cysteine (TCVC).

Committee to Review EPA's Toxicological Assessment of Tetrachloroethylene, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies; Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene. 186 pp. (2010). The National Academies Press, 500 Fifth Street, NW Washington, DC 20001. Available from, as of March 22, 2018: https://www.nap.edu/catalog/12863.html


For more Metabolism/Metabolites (Complete) data for Tetrachloroethylene (19 total), please visit the HSDB record page.


5.4 Biological Half-Life

Blood: 96 hours; trichloroacetic acid in urine: 80 hours (may be longer depending upon fat deposition); [TDR, p. 1010]

TDR - Ryan RP, Terry CE, Leffingwell SS (eds). Toxicology Desk Reference: The Toxic Exposure and Medical Monitoring Index, 5th Ed. Washington DC: Taylor & Francis, 1999., p. 1010


After ingestion of 12-16 g tetrachloroethylene, a 6 year old boy was admitted to the clinic in coma. ... The tetrachloroethylene blood level profile which was determined under hyperventilation therapy could be computer fitted to a two compartment model. Elimination of tetrachloroethylene from the blood compartment occurred via a rapid and a slow process with half-lives of 30 min and 35 hours, respectively. These values compared favorably with the half-lives of 160 min and 33 hours under normal respiratory conditions. ...

PMID:4057308 Koppel C et al; J Toxicol Clin Toxicol 23 (2-3): 103-15 (1985)


The elimination of tetrachloroethylene in expired air ranged from 50 to 150 ppm (339 to 1,017 mg/cu m) for up to 8 hr. Biological half-life for fat stores was 71.5 hr.

Gruberan E, Fernandez J; Brit J Ind Med 31: 159 (1974)


The biological half-life of tetrachloroethylene metabolites (as measured as total trichloro-compounds) is 144 hours.

Ikeda M and Imamura T; Int Arch Arbeitsmed 31: 209 (1973)


The excretion via blood and lungs occurred at 3 different rate constants with half-lives of 12-16 hr, 30-40 hr, and about 55 hr, respectively, 20, 50, and 100 hr after exposure. Trichloroacetic acid was excreted from blood with a half-life of 75-80 hr ... The half-life of this metabolite in urine /is/ about 6 days.

WHO; Environmental Health Criteria Document No. 31: Tetrachloroethylene (127-18-4) (1984). Available from, as of March 21, 2018: https://www.inchem.org/pages/ehc.html


Half-lives for respiratory elimination range from 1 to 72 hr.

International Programme on Chemical Safety's Concise International Chemical Assessment Documents. Number 68: Tetrachloroethene (127-18-4). Available from, as of March 21, 2018: https://www.inchem.org/pages/cicads.html