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    Tetrahydrozoline

    ACTIVE PHARMA INGREDIENTS

    INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

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    $ API Ref.Price (USD/KG) : 290,200Xls

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    2D Structure
    Also known as: 522-48-5, Tetrahydrozoline hcl, Tetryzoline hydrochloride, Tyzine, Visine, Murine plus
    Molecular Formula
    C13H17ClN2
    Molecular Weight
    236.74  g/mol
    InChI Key
    BJORNXNYWNIWEY-UHFFFAOYSA-N
    FDA UNII
    0YZT43HS7D
    Tetrahydrozoline Hydrochloride is the hydrochloride salt form of tetrahydrozoline, an imidazole derivative with sympathomimetic property. Applied locally to the eye or nose, tetrahydrozoline binds to and activates alpha-adrenergic receptors, resulting in vasoconstriction and decreased nasal and ophthalmic congestion.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole;hydrochloride
    2.1.2 InChI
    InChI=1S/C13H16N2.ClH/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13;/h1-2,4,6,12H,3,5,7-9H2,(H,14,15);1H
    2.1.3 InChI Key
    BJORNXNYWNIWEY-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CC(C2=CC=CC=C2C1)C3=NCCN3.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    0YZT43HS7D
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline

    2. Berberil N

    3. Caltheon

    4. Collyrium Fresh

    5. Diabenyl T

    6. Eye-sine

    7. Eye-zine

    8. Murine Plus

    9. Murine Sore Eyes

    10. Ophtalmin

    11. Optazine Fresh

    12. Optigene

    13. Rhinopront

    14. Tetra-ide

    15. Tetraclear

    16. Tetrahydrozoline

    17. Tetrahydrozoline Monohydrochloride

    18. Tetrahydrozoline, (+-)-isomer

    19. Tetrahydrozoline, (-)-isomer

    20. Tetrilin

    21. Tetryzoline

    22. Tyzine

    23. Vasopos

    24. Visine

    25. Vispring

    26. Yxin

    2.3.2 Depositor-Supplied Synonyms

    1. 522-48-5

    2. Tetrahydrozoline Hcl

    3. Tetryzoline Hydrochloride

    4. Tyzine

    5. Visine

    6. Murine Plus

    7. Vasopos

    8. Tyzanol Hydrochloride

    9. 2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1h-imidazole Hydrochloride

    10. Tetrahydrozoline (hydrochloride)

    11. Nsc-757339

    12. 0yzt43hs7d

    13. Mls000069739

    14. 2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline Hydrochloride

    15. 2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline Monohydrochloride

    16. 1h-imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, Monohydrochloride

    17. 2-tetralin-1-yl-4,5-dihydro-1h-imidazole Hydrochloride

    18. 522-48-5 (hcl)

    19. Smr000058219

    20. 2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1h-imidazole;hydrochloride

    21. 1h-imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, Hydrochloride (1:1)

    22. Dsstox_cid_25316

    23. Dsstox_rid_80797

    24. Dsstox_gsid_45316

    25. Rhinopront

    26. Yxin

    27. 2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1h-imidazole Hcl

    28. Sr-01000000161

    29. Einecs 208-329-3

    30. Unii-0yzt43hs7d

    31. Ai3-50165

    32. Tetryzoline Hcl

    33. Tetrahydrozoline Monohydrochloride

    34. Tetrahydrozoline Hydrochloride [usp]

    35. Mfcd00058029

    36. Prestwick_1025

    37. Tyzine (tn)

    38. Opera_id_1724

    39. Ncgc00016485-01

    40. Cas-522-48-5

    41. Schembl25702

    42. Mls000079025

    43. Mls001146954

    44. Mls002222291

    45. Mls002548902

    46. Spectrum1500567

    47. Chebi:9492

    48. Chembl1200413

    49. Dtxsid7045316

    50. Hy-b0556a

    51. Hms1570k17

    52. Hms1921c21

    53. Pharmakon1600-01500567

    54. Bcp15857

    55. Tox21_110450

    56. Tox21_501137

    57. Ccg-39268

    58. Nsc757339

    59. 2-imidazoline, 2-(1,2,3,4-tetrahydro-1-naphthyl)-, Hydrochloride

    60. Akos015899540

    61. Tox21_110450_1

    62. Ac-1110

    63. Lp01137

    64. Nc00484

    65. Nsc 757339

    66. Tetrahydrozoline Hydrochloride, >=98%

    67. Ncgc00016018-10

    68. Ncgc00094403-01

    69. Ncgc00094403-02

    70. Ncgc00094403-03

    71. Ncgc00094403-04

    72. Ncgc00094403-05

    73. Ncgc00261822-01

    74. Tetryzoline Hydrochloride [mart.]

    75. As-15973

    76. Tetrahydrozoline Hydrochloride (jan/usp)

    77. Tetryzoline Hydrochloride [who-dd]

    78. Tetrahydrozoline Hydrochloride [mi]

    79. Tetrahydrozoline Hydrochloride [jan]

    80. Eu-0101137

    81. Ft-0675067

    82. S4043

    83. Sw197098-3

    84. T3148

    85. Tetrahydrozoline Hydrochloride [vandf]

    86. Vu0239726-5

    87. D01023

    88. T 4264

    89. Tetrahydrozoline Hydrochloride [usp-rs]

    90. Tetryzoline Hydrochloride [ep Monograph]

    91. 522t485

    92. A851840

    93. Q-201816

    94. Sr-01000000161-2

    95. Sr-01000000161-8

    96. Tetrahydrozoline Hydrochloride [orange Book]

    97. Q27237368

    98. Tetrahydrozoline Hydrochloride [usp Monograph]

    99. Z1695906783

    100. 1h-imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-,monohydrochloride

    101. 2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1h-imidazolehydrochloride

    102. 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazole Hydrochloride

    103. 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazole Monohydrochloride

    104. Tetrahydrozoline Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    105. Tetrahydrozoline Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    106. Tetrahydrozoline Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 236.74 g/mol
    Molecular Formula C13H17ClN2
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count1
    Rotatable Bond Count1
    Exact Mass236.1080262 g/mol
    Monoisotopic Mass236.1080262 g/mol
    Topological Polar Surface Area24.4 Ų
    Heavy Atom Count16
    Formal Charge0
    Complexity259
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameTyzine
    Drug LabelTyzine Nasal Solution contains tetrahydrozoline hydrochloride, 2-(1,2,3,4-Tetrahydro-1, naphthyl)-2-imidazoline monohydrochloride, as a nasal decongestant. The chemical structure is:Nasal Solution is available for topical nasal application as 0.1%...
    Active IngredientTetrahydrozoline hydrochloride
    Dosage FormSpray; Solution
    RouteNasal
    Strength0.05%; 0.1%
    Market StatusPrescription
    CompanyFougera Pharms

    2 of 2  
    Drug NameTyzine
    Drug LabelTyzine Nasal Solution contains tetrahydrozoline hydrochloride, 2-(1,2,3,4-Tetrahydro-1, naphthyl)-2-imidazoline monohydrochloride, as a nasal decongestant. The chemical structure is:Nasal Solution is available for topical nasal application as 0.1%...
    Active IngredientTetrahydrozoline hydrochloride
    Dosage FormSpray; Solution
    RouteNasal
    Strength0.05%; 0.1%
    Market StatusPrescription
    CompanyFougera Pharms

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Ophthalmic Solutions

    Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS. (See all compounds classified as Ophthalmic Solutions.)

    Nasal Decongestants

    Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993) (See all compounds classified as Nasal Decongestants.)

    Sympathomimetics

    Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)