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    Thioridazine Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    GLOBAL SALES INFORMATION

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    REF. STANDARDS & IMPURITIES

    ANALYTICAL

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    $ API Ref.Price (USD/KG) : 491Xls

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    2D Structure
    Also known as: 130-61-0, Thioridazine hcl, Sonapax hydrochloride, Thioridazine chloride, Mellaril hydrochloride, Aldazine
    Molecular Formula
    C21H27ClN2S2
    Molecular Weight
    407.0  g/mol
    InChI Key
    NZFNXWQNBYZDAQ-UHFFFAOYSA-N
    FDA UNII
    4WCI67NK8M
    A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine;hydrochloride
    2.1.2 InChI
    InChI=1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H
    2.1.3 InChI Key
    NZFNXWQNBYZDAQ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    4WCI67NK8M
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Aldazine

    2. Apo Thioridazine

    3. Apo-thioridazine

    4. Apothioridazine

    5. Meleril

    6. Mellaril

    7. Melleretten

    8. Melleril

    9. Melleryl

    10. Melzine

    11. Rideril

    12. Sonapax

    13. Thioridazine

    14. Thioridazine Hcl

    15. Thioridazine Neurazpharm

    16. Thioridazine-neurazpharm

    17. Thioridazineneurazpharm

    18. Thiozine

    2.3.2 Depositor-Supplied Synonyms

    1. 130-61-0

    2. Thioridazine Hcl

    3. Sonapax Hydrochloride

    4. Thioridazine Chloride

    5. Mellaril Hydrochloride

    6. Aldazine

    7. Thioridazine (hydrochloride)

    8. Usaf Sz-b

    9. Usaf Sz-3

    10. 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10h-phenothiazine Hydrochloride

    11. Nsc-186060

    12. 4wci67nk8m

    13. Mls000028408

    14. Chebi:48566

    15. Orsanil

    16. 10-(2-(1-methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine Monohydrochloride

    17. 2-methylmercapto-10-(2-(n-methyl-2-piperidyl)ethyl)phenothiazine Hydrochloride

    18. 10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylthio)-10h-phenothiazine Hydrochloride

    19. 10h-phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylthio)-, Monohydrochloride

    20. Smr000058380

    21. Thioridazine.hcl

    22. 10-(2-(1-methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine Hydrochloride

    23. 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine;hydrochloride

    24. Melleril (tablet)

    25. Melzine

    26. 10h-phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-, Monohydrochloride

    27. 2-methylmercapto-10-[2-(n-methyl-2-piperidyl)ethyl]phenothiazine Hydrochloride

    28. Nsc186060

    29. Thioridazine Hydrochloride [jan]

    30. Einecs 204-992-8

    31. Unii-4wci67nk8m

    32. Nsc 186060

    33. Tioridazin

    34. Metlaril

    35. 10-[2-(1-methyl-2-piperidyl)ethyl]-2-(methylthio)-10h-phenothiazine Hydrochloride

    36. Sr-01000000063

    37. 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylthiophenothiazine Hydrochloride

    38. 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylthio)-10h-phenothiazine Hydrochloride

    39. Thioridazine Hydrochloride Intensol

    40. Mellaril (tn)

    41. Prestwick_437

    42. Mfcd00012655

    43. Thioridazine Hydrochloride [usp:jan]

    44. Thoridazine Hydrochloride

    45. Opera_id_1713

    46. Cas-130-61-0

    47. Dsstox_cid_29360

    48. Dsstox_rid_83476

    49. Dsstox_gsid_49401

    50. Schembl41430

    51. Mls001148599

    52. Mls002222212

    53. Spectrum1500575

    54. Chembl1200916

    55. Dtxsid9049401

    56. Hms1568o17

    57. Hms1921e11

    58. Pharmakon1600-01500575

    59. Bcp19941

    60. Hy-b0965

    61. Thioridazine Hydrochloride, >=99%

    62. Tox21_202801

    63. Tox21_501252

    64. Ccg-39270

    65. Nsc757349

    66. S5563

    67. Akos015994763

    68. Cs-4450

    69. Ks-5108

    70. Lp01252

    71. Nc00594

    72. Nsc-757349

    73. Thioridazine Hydrochloride (jp17/usp)

    74. Thioridazine Hydrochloride [mi]

    75. Phenothiazine, 10-(2-(1-methyl-2-piperidyl)ethyl)-2-(methylthio)-, Monohydrochloride

    76. Ncgc00094492-01

    77. Ncgc00094492-02

    78. Ncgc00094492-03

    79. Ncgc00094492-04

    80. Ncgc00094492-05

    81. Ncgc00260347-01

    82. Ncgc00261937-01

    83. Thioridazine Hydrochloride [mart.]

    84. Thioridazine Hydrochloride [vandf]

    85. Thioridazine Hydrochloride [usp-rs]

    86. Thioridazine Hydrochloride [who-dd]

    87. Db-041975

    88. Eu-0101252

    89. Ft-0631759

    90. Ft-0675189

    91. Sw196660-3

    92. T3102

    93. D00798

    94. D82085

    95. T 9025

    96. Thioridazine Hydrochloride [orange Book]

    97. Thioridazine Hydrochloride [ep Monograph]

    98. A806110

    99. Thioridazine Hydrochloride [usp Monograph]

    100. Sr-01000000063-2

    101. Sr-01000000063-7

    102. W-108347

    103. Q27104616

    104. Wln: T C666 Bn Isj Es1 B2-bt6ntj A1 & Gh

    105. Z2784093622

    106. Thioridazine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    107. Dopamine Receptor Antagonist Ii, Thioridazine, Hcl - Cas 130-61-0

    108. Thioridazine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    109. 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-10h-phenothiazine Hydrochloride

    110. Thioridazine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 407.0 g/mol
    Molecular Formula C21H27ClN2S2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count4
    Exact Mass406.1304189 g/mol
    Monoisotopic Mass406.1304189 g/mol
    Topological Polar Surface Area57.1 Ų
    Heavy Atom Count26
    Formal Charge0
    Complexity432
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameThioridazine hydrochloride
    Drug LabelThioridazine hydrochloride is 2-methylmercapto-10-[2-(N-methyl-2-piperidyl) ethyl] phenothiazine. Its structural formula, molecular weight and molecular formula are:C21H26N2S2 HCl M.Wt.: 407.05Thioridazine hydrochlorid...
    Active IngredientThioridazine hydrochloride
    Dosage FormTablet
    RouteOral
    Strength25mg; 100mg; 50mg; 10mg
    Market StatusPrescription
    CompanyMutual Pharm; Mylan

    2 of 2  
    Drug NameThioridazine hydrochloride
    Drug LabelThioridazine hydrochloride is 2-methylmercapto-10-[2-(N-methyl-2-piperidyl) ethyl] phenothiazine. Its structural formula, molecular weight and molecular formula are:C21H26N2S2 HCl M.Wt.: 407.05Thioridazine hydrochlorid...
    Active IngredientThioridazine hydrochloride
    Dosage FormTablet
    RouteOral
    Strength25mg; 100mg; 50mg; 10mg
    Market StatusPrescription
    CompanyMutual Pharm; Mylan

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Dopamine Antagonists

    Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Phenothiazines [CS]; Phenothiazine [EPC]