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    Tiapride Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    GLOBAL SALES INFORMATION

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    REF. STANDARDS & IMPURITIES

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    2D Structure
    Also known as: 51012-33-0, Tiapride hcl, Tiapridal, Tiapride (hydrochloride), Gramalil, Italprid
    Molecular Formula
    C15H25ClN2O4S
    Molecular Weight
    364.9  g/mol
    InChI Key
    OTFDPNXIVHBTKW-UHFFFAOYSA-N
    FDA UNII
    25N106WEDO
    A benzamide derivative that is used as a dopamine antagonist.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide;hydrochloride
    2.1.2 InChI
    InChI=1S/C15H24N2O4S.ClH/c1-5-17(6-2)10-9-16-15(18)13-11-12(22(4,19)20)7-8-14(13)21-3;/h7-8,11H,5-6,9-10H2,1-4H3,(H,16,18);1H
    2.1.3 InChI Key
    OTFDPNXIVHBTKW-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCN(CC)CCNC(=O)C1=C(C=CC(=C1)S(=O)(=O)C)OC.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    25N106WEDO
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Equilium

    2. Flo 1347

    3. Flo-1347

    4. Flo1347

    5. Hydrochloride, Tiapride

    6. Monohydrochloride, Tiapride

    7. Tiapridal

    8. Tiapride

    9. Tiapride Monohydrochloride

    10. Tiapridex

    11. Tiaprizal

    2.3.2 Depositor-Supplied Synonyms

    1. 51012-33-0

    2. Tiapride Hcl

    3. Tiapridal

    4. Tiapride (hydrochloride)

    5. Gramalil

    6. Italprid

    7. Luxoben

    8. Sereprile

    9. Tiapridex

    10. Tiapridehydrochloride

    11. Mls000069678

    12. N-[2-(diethylamino)ethyl]-5-(methylsulfonyl)-o-anisamide Hydrochloride

    13. Tiapride Hydrochloride [jan]

    14. Benzamide, N-[2-(diethylamino)ethyl]-2-methoxy-5-(methylsulfonyl)-,monohydrochloride

    15. Smr000058514

    16. Dsstox_cid_25210

    17. Dsstox_rid_80753

    18. Dsstox_gsid_45210

    19. N-(2-(diethylamino)ethyl)-2-methoxy-5-(methylsulfonyl)benzamide Hydrochloride

    20. 25n106wedo

    21. Sr-01000000232

    22. Ncgc00015996-02

    23. Cas-51012-33-0

    24. N-(2-[diethylamino]ethyl)-5-(methylsulfonyl)-o-anisamide Hydrochloride

    25. N-[2-(diethylamino)ethyl]-2-methoxy-5-(methylsulfonyl)benzamide Hydrochloride

    26. Gramalil (tn)

    27. Prestwick_580

    28. Mfcd00133861

    29. Benzamide, N-(2-(diethylamino)ethyl)-2-methoxy-5-(methylsulfonyl)-, Monohydrochloride

    30. Opera_id_408

    31. Tiapride Hydrochloride,(s)

    32. Mls001076118

    33. Schembl355315

    34. Spectrum1503086

    35. Tiapride Hydrochloride (jp17)

    36. Chembl1256772

    37. Dtxsid4045210

    38. Chebi:32220

    39. Hms1568l13

    40. Hms1922e05

    41. Pharmakon1600-01503086

    42. Tiapride Hydrochloride [mi]

    43. Bcp13379

    44. Hy-b1196

    45. Tox21_110276

    46. Tox21_501124

    47. Ccg-39299

    48. Nsc758225

    49. Akos015891372

    50. Tiapride Hydrochloride [mart.]

    51. Tox21_110276_1

    52. Ab03720

    53. Cs-4804

    54. Hs-0005

    55. Lp01124

    56. Tiapride Hydrochloride [who-dd]

    57. Ncgc00015996-10

    58. Ncgc00094392-01

    59. Ncgc00094392-02

    60. Ncgc00094392-03

    61. Ncgc00094392-04

    62. Ncgc00094392-05

    63. Ncgc00261809-01

    64. Bt166255

    65. Eu-0101124

    66. Ft-0630638

    67. S9509

    68. T3600

    69. Tiapride Hydrochloride [ep Monograph]

    70. D01522

    71. T 0410

    72. T72548

    73. Sr-01000000232-2

    74. Sr-01000000232-6

    75. Q27253983

    76. N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide,hydrochloride

    77. Benzamide, N-(2-(diethylamino)ethyl)-2-methoxy-5-(methylsulfonyl)-, Hydrochloride (1:1)

    2.4 Create Date
    2006-03-07
    3 Chemical and Physical Properties
    Molecular Weight 364.9 g/mol
    Molecular Formula C15H25ClN2O4S
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count8
    Exact Mass364.1223562 g/mol
    Monoisotopic Mass364.1223562 g/mol
    Topological Polar Surface Area84.1 Ų
    Heavy Atom Count23
    Formal Charge0
    Complexity443
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

    Dopamine Antagonists

    Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)