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    Tilbroquinol

    PharmaCompass
    Xls

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    2D Structure
    Also known as: 7-bromo-5-methylquinolin-8-ol, 7175-09-9, 7-bromo-5-methyl-8-quinolinol, Tilbroquinol [inn], P6sb125nha, Tilbroquinol (inn)
    Molecular Formula
    C10H8BrNO
    Molecular Weight
    238.08  g/mol
    InChI Key
    JMOVFFLYGIQXMM-UHFFFAOYSA-N
    FDA UNII
    P6SB125NHA
    Tilbroquinol was approved in France, Morocco, and Saudi Arabia but it has been withdrawn in France and Saudi Arabia markets mainly due to its hepatotoxicity risk outweighing the drug benefit. In Morocco, the drug has been limited to use in the treatment of intestinal amoebiasis.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    7-bromo-5-methylquinolin-8-ol
    2.1.2 InChI
    InChI=1S/C10H8BrNO/c1-6-5-8(11)10(13)9-7(6)3-2-4-12-9/h2-5,13H,1H3
    2.1.3 InChI Key
    JMOVFFLYGIQXMM-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=CC(=C(C2=C1C=CC=N2)O)Br
    2.2 Other Identifiers
    2.2.1 UNII
    P6SB125NHA
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 7-bromo-5-methyl-8-quinolinol

    2.3.2 Depositor-Supplied Synonyms

    1. 7-bromo-5-methylquinolin-8-ol

    2. 7175-09-9

    3. 7-bromo-5-methyl-8-quinolinol

    4. Tilbroquinol [inn]

    5. P6sb125nha

    6. Tilbroquinol (inn)

    7. Tilbroquinolum

    8. Tilbroquinolum [inn-latin]

    9. Einecs 230-533-6

    10. 5-methyl-7-bromo-8-hydroxyquinoline

    11. Unii-p6sb125nha

    12. Tilbroquinol [mart.]

    13. Tilbroquinol [who-dd]

    14. Schembl1441958

    15. Zinc2170

    16. Chembl1788385

    17. Dtxsid80221973

    18. Chebi:134965

    19. Amy23445

    20. 8-hydroxy-7-bromo-5-methylquinoline

    21. Cs-1390

    22. Db13222

    23. Hy-15537

    24. Db-074468

    25. Ft-0757627

    26. D07351

    27. A917909

    28. Q7802069

    29. W-110201

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 238.08 g/mol
    Molecular Formula C10H8BrNO
    XLogP33.1
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count0
    Exact Mass236.97893 g/mol
    Monoisotopic Mass236.97893 g/mol
    Topological Polar Surface Area33.1 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity188
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 ATC Code

    P - Antiparasitic products, insecticides and repellents

    P01 - Antiprotozoals

    P01A - Agents against amoebiasis and other protozoal diseases

    P01AA - Hydroxyquinoline derivatives

    P01AA05 - Tilbroquinol