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    Tilorone Dihydrochloride

    ACTIVE PHARMA INGREDIENTS

    MARKET PLACE

    PharmaCompass
    $ API Ref.Price (USD/KG) : 378Xls

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    2D Structure
    Also known as: 27591-69-1, Tilorone hydrochloride, Tilorone 2hcl, Tilorone hcl, Tilorone (dihydrochloride), Deae-f
    Molecular Formula
    C25H36Cl2N2O3
    Molecular Weight
    483.5  g/mol
    InChI Key
    BSVYJQAWONIOOU-UHFFFAOYSA-N
    FDA UNII
    BJ507J4LKY
    An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one;dihydrochloride
    2.1.2 InChI
    InChI=1S/C25H34N2O3.2ClH/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19;;/h9-12,17-18H,5-8,13-16H2,1-4H3;2*1H
    2.1.3 InChI Key
    BSVYJQAWONIOOU-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCN(CC)CCOC1=CC2=C(C=C1)C3=C(C2=O)C=C(C=C3)OCCN(CC)CC.Cl.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    BJ507J4LKY
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Amiksin

    2. Amixin

    3. Amyxin

    4. Bis Deae Fluorenone

    5. Bis-deae-fluorenone

    6. Hydrochloride, Tilorone

    7. Tilorone

    8. Tilorone Hydrochloride

    2.3.2 Depositor-Supplied Synonyms

    1. 27591-69-1

    2. Tilorone Hydrochloride

    3. Tilorone 2hcl

    4. Tilorone Hcl

    5. Tilorone (dihydrochloride)

    6. Deae-f

    7. Tilorone Hydrochloride [usan]

    8. Nsc-143969

    9. 2,7-bis[2-(diethylamino)ethoxy]-9-fluorenone Dihydrochloride

    10. Bj507j4lky

    11. Rmi 10008da

    12. 2,7-bis(2-(diethylamino)ethoxy)fluoren-9-one Dihydrochloride

    13. 9h-fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-, Dihydrochloride

    14. 9h-fluoren-9-one, 2,7-bis[2-(diethylamino)ethoxy]-, Dihydrochloride

    15. Tilorone Hydrochloride (usan)

    16. 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one Dihydrochloride

    17. Bis-deae-fluorenone Hydrochloride

    18. Unii-bj507j4lky

    19. Lavomax

    20. Amixin

    21. 2,7-bis(2-(diethylamino)ethoxy)-9h-fluoren-9-one Dihydrochloride

    22. 2,7-bis[2-(diethylamino)ethoxy]-9h-fluoren-9-one Dihydrochloride

    23. Tilorone Dihcl

    24. 2,7-bis(2-diethylaminoethoxy)fluoren-9-one Dihydrochloride

    25. Tiloronedihydrochloride

    26. Schembl146373

    27. Tilorone Dihydrochloride, 95%

    28. Chembl539581

    29. Chebi:147356

    30. Act08564

    31. Amy10986

    32. Bcp18046

    33. Ex-a5740

    34. Hy-b1080

    35. Mfcd00134071

    36. S5020

    37. Tilorone Dihydrochloride [mi]

    38. Akos005145903

    39. Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-, Dihydrochloride

    40. Tilorone Hydrochloride [mart.]

    41. Ccg-269573

    42. Cs-4636

    43. Ks-5182

    44. Tilorone Hydrochloride [who-dd]

    45. Ft-0656019

    46. T2836

    47. D06149

    48. 591t691

    49. J-016822

    50. J-524971

    51. Q27274704

    52. 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one;dihydrochloride

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 483.5 g/mol
    Molecular Formula C25H36Cl2N2O3
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count12
    Exact Mass482.2102984 g/mol
    Monoisotopic Mass482.2102984 g/mol
    Topological Polar Surface Area42 Ų
    Heavy Atom Count32
    Formal Charge0
    Complexity477
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents

    Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

    Antiviral Agents

    Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

    Antineoplastic Agents

    Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

    Interferon Inducers

    Agents that promote the production and release of interferons. They include mitogens, lipopolysaccharides, and the synthetic polymers Poly A-U and Poly I-C. Viruses, bacteria, and protozoa have been also known to induce interferons. (See all compounds classified as Interferon Inducers.)