Please Wait
Applying Filters...
menu
    • menu
    DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

    Virtual Booth

    Contact Supplier

    Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    With Fermion, start the journey of your innovative API.

    Virtual Booth

    Contact Supplier

    Bloomage is a one-stop source for CEP Sodium Hyaluronate and Hyaluronic Acid// FDA-inspected & GMP-certified.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    Menu

    Tiludronic Acid

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    PharmaCompass
    Xls

    Filters

    clear-filterReset all filters
    2D Structure
    Also known as: 149845-07-8, Tiludronic acid disodium salt, Skelid, Disodium tiludronate, Sr 41319b, Tiludronate disodium [usan]
    Molecular Formula
    C7H7ClNa2O6P2S
    Molecular Weight
    362.57  g/mol
    InChI Key
    SKUHWSDHMJMHIW-UHFFFAOYSA-L
    FDA UNII
    BH6M93CIA0
    Tiludronate Disodium is the disodium salt form of tiludronate, a first-generation, non-nitrogenous bisphosphonate analogue of endogenous pyrophosphate. Tiludronate adsorbs to hydroxyapatite cells, and although the exact mechanism through which this bisphosphonate exerts its effect has yet to be fully elucidated, tiludronate appears to inhibit protein-tyrosine-phosphatase (PTP) in osteoclasts, thereby disrupting the cytoskeletal ring structure and suppressing the bone resorbing activity of osteoclasts. In addition, tiludronate appears to inhibit the vacuolar-type proton ATPase (V-ATPase) in osteoclasts. Altogether, this may reduce the number of osteoclasts, inhibit abnormal bone resorption and reduce bone turnover.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    disodium;[(4-chlorophenyl)sulfanyl-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate
    2.1.2 InChI
    InChI=1S/C7H9ClO6P2S.2Na/c8-5-1-3-6(4-2-5)17-7(15(9,10)11)16(12,13)14;;/h1-4,7H,(H2,9,10,11)(H2,12,13,14);;/q;2*+1/p-2
    2.1.3 InChI Key
    SKUHWSDHMJMHIW-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    C1=CC(=CC=C1SC(P(=O)(O)[O-])P(=O)(O)[O-])Cl.[Na+].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    BH6M93CIA0
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (4-chlorophenyl)thiomethylene Bisphosphonic Acid

    2. (chloro-4-phenyl)thiomethylene Biphosphonate

    3. (chloro-4-phenyl)thiomethylene Bisphosphonate

    4. Cl2smbp

    5. Skelid

    6. Tiludronate

    7. Tiludronic Acid

    2.3.2 Depositor-Supplied Synonyms

    1. 149845-07-8

    2. Tiludronic Acid Disodium Salt

    3. Skelid

    4. Disodium Tiludronate

    5. Sr 41319b

    6. Tiludronate Disodium [usan]

    7. Tiludronate Sodium

    8. Tiludronic Acid, Disodium Salt

    9. Sr-41319b

    10. Tiludronic Acid (disodium)

    11. Bh6m93cia0

    12. Tiludronate (disodium)

    13. Tiludronate Disodium Anhydrous

    14. Disodium Dihydrogen (((p-chlorophenyl)thio)methylene)diphosphonate

    15. 149845-07-8 (sodium)

    16. Phosphonic Acid, (((4-chlorophenyl)thio)methylene)bis-, Disodium Salt

    17. Tiludronate Disodium (usan)

    18. [(4-chlorophenyl)sulfanyl-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate Disodium

    19. Phosphonic Acid, [[(4-chlorophenyl)thio]methylene]bis-, Sodium Salt (1:2)

    20. Ncgc00182026-01

    21. Unii-bh6m93cia0

    22. Skelid (tn)

    23. Cl-tmbp

    24. Dsstox_cid_28547

    25. Dsstox_rid_82819

    26. Dsstox_gsid_48621

    27. Schembl41053

    28. Chembl1200448

    29. Dtxsid1048621

    30. Bcp22736

    31. Tiludronate Sodium [who-dd]

    32. Tiludronate Disodium [vandf]

    33. Tox21_112961

    34. Disodium [[(4-chlorophenyl)thio]methylene]bis(hydrogenphosphonate)

    35. Mfcd04039691

    36. Tiludronate Disodium [mart.]

    37. Akos015894005

    38. Me-3737

    39. Disodium;[(4-chlorophenyl)sulfanyl-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate

    40. Tiludronate Disodium [green Book]

    41. As-73111

    42. Tiludronate Disodium [orange Book]

    43. Tiludronic Acid Disodium Salt [mi]

    44. Cas-149845-07-8

    45. D4167

    46. Ft-0675237

    47. D02285

    48. D90259

    49. J-008635

    50. Q27274665

    51. Disodium Hydrogen {[(4-chlorophenyl)sulfanyl](hydrogen Phosphonato)methyl}phosphonate

    52. Disodium [(4-chlorophenyl)sulfanyl-(hydroxy-oxido-phosphoryl)methyl]-hydroxy-oxido-oxo-phosphorane

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 362.57 g/mol
    Molecular Formula C7H7ClNa2O6P2S
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count4
    Exact Mass361.8922494 g/mol
    Monoisotopic Mass361.8922494 g/mol
    Topological Polar Surface Area146 Ų
    Heavy Atom Count19
    Formal Charge0
    Complexity320
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Bone Density Conservation Agents

    Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)