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    Timonacic

    ACTIVE PHARMA INGREDIENTS

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    $ API Ref.Price (USD/KG) : 121Xls

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    2D Structure
    Also known as: Thiazolidine-4-carboxylic acid, 444-27-9, 1,3-thiazolidine-4-carboxylic acid, Detoxepa, Hepalidine, Thioproline
    Molecular Formula
    C4H7NO2S
    Molecular Weight
    133.17  g/mol
    InChI Key
    DZLNHFMRPBPULJ-UHFFFAOYSA-N
    FDA UNII
    E5913T3IBL
    Timonacic is a cyclic sulfur amino acid derivative with potential antineoplastic and antioxidant activities. Acting on cellular membranes of malignant cells through an unknown mechanism, timonacic may induce malignant cells to revert back to an untransformed state. This agent may also restore contact inhibition, a phenomenon characterized by the paracrine inhibition of mitosis following the formation of a critical cell mass, presumably the result of cell-to-cell signal transfer. Timonacic may also produce antioxidant effects secondary to its release of cysteine and restoration of glutathione concentrations.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1,3-thiazolidine-4-carboxylic acid
    2.1.2 InChI
    InChI=1S/C4H7NO2S/c6-4(7)3-1-8-2-5-3/h3,5H,1-2H2,(H,6,7)
    2.1.3 InChI Key
    DZLNHFMRPBPULJ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1C(NCS1)C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    E5913T3IBL
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Gamma-thiaproline

    2. Heparegen

    3. Norgamem

    4. Thiaproline

    5. Thiazolidine-4-carboxylic Acid

    6. Thiazolidine-4-carboxylic Acid, (r)-isomer

    7. Thiazolidine-4-carboxylic Acid, Sodium Salt

    8. Thioproline

    2.3.2 Depositor-Supplied Synonyms

    1. Thiazolidine-4-carboxylic Acid

    2. 444-27-9

    3. 1,3-thiazolidine-4-carboxylic Acid

    4. Detoxepa

    5. Hepalidine

    6. Thioproline

    7. 4-thiazolidinecarboxylic Acid

    8. Tiazolidin

    9. Heparegene

    10. Norgamem

    11. Thiaproline

    12. L-thiazolidine-4-carboxylic Acid

    13. Dl-thiaproline

    14. 4-carboxythiazolidine

    15. Norgamen

    16. Usaf C-1

    17. T-4ca

    18. Timonacic [inn]

    19. Heptaladine

    20. Timonacicum

    21. Hepaldine

    22. Heparegen

    23. Timonacico

    24. Usaf A-3701

    25. Dl-thiazolidinecarboxylic Acid

    26. Hepacom

    27. Nsc 25855

    28. Nsc-25855

    29. Acide Thiazolidine-4-carboxylique

    30. Thiazolidinecarboxylic Acid

    31. Acide Dl Thiazolidine Carboxylique-4

    32. Mfcd00128958

    33. E5913t3ibl

    34. Chebi:64564

    35. Timonacic (inn)

    36. Nsc25855

    37. 4-thiazolidinecarboxylic Acid, L-

    38. Timonacicum [inn-latin]

    39. Timonacico [inn-spanish]

    40. Thiazolidinecarboxylic Acid (van)

    41. Einecs 207-146-6

    42. Einecs 242-945-3

    43. 4-thiazolidinecarboxylicacid

    44. Thiazolidin

    45. Unii-e5913t3ibl

    46. Thiazolidine-4-carboxylicacid

    47. Acide Thiazolidine-4-carboxylique [french]

    48. Ccris 8099

    49. Acide Dl Thiazolidine Carboxylique-4 [french]

    50. L-4-thiazolidinecarboxylic Acid, 98%

    51. Pidotimod Impurity

    52. Hepacom (tn)

    53. Timonacic [mi]

    54. Timonacic [inci]

    55. Timonacic [mart.]

    56. 4-thiazolidincarboxylic Acid

    57. Schembl8356

    58. Timonacic [who-dd]

    59. H-d-thz-oh;d-thioproline

    60. Wln: T5m Cstj Evq

    61. Thiazolidine-4-caboxylic Acid

    62. Thiazolidin-4-carboxylic Acid

    63. Chembl358722

    64. Dtxsid9023675

    65. Wln: T5m Cstj Evq -l

    66. Dl-thiazolidine-4-carboxylic Acid

    67. Hms3264c18

    68. Pharmakon1600-01503320

    69. Act03153

    70. Albb-005988

    71. Bcp13616

    72. Hy-b1169

    73. 1,3-thiazolidane-4-carboxylic Acid

    74. Nsc758453

    75. S4993

    76. Stk361805

    77. Akos000119343

    78. Akos016040292

    79. Racemic Thiazolidine-4-carboxylic Acid

    80. 1,3-thiazolidine-4-carboxylic Acid #

    81. Ab03779

    82. Am81428

    83. Ccg-213875

    84. Cs-8024

    85. Db12856

    86. Nsc-758453

    87. As-13539

    88. Sbi-0207087.p001

    89. 4-thiazolidinecarboxylic Acid, (.+/-.)-

    90. Db-048659

    91. Bb 0254773

    92. Ft-0639201

    93. Ft-0653153

    94. Ft-0675152

    95. Ft-0679172

    96. A18785

    97. D08601

    98. D97373

    99. Ab01563202_01

    100. (r)-thiazolidine-4-carboxylic Acid;l-thioproline

    101. 592t477

    102. A876895

    103. Ah-232/20359048

    104. L(-)-thiazolidine-4-carboxylic Acid;l-thiaproline

    105. Sr-01000944258

    106. Sr-01000944258-1

    107. Q23637400

    108. Z955123540

    109. 60731-25-1

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 133.17 g/mol
    Molecular Formula C4H7NO2S
    XLogP3-2.3
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count1
    Exact Mass133.01974964 g/mol
    Monoisotopic Mass133.01974964 g/mol
    Topological Polar Surface Area74.6 Ų
    Heavy Atom Count8
    Formal Charge0
    Complexity106
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antidotes

    Agents counteracting or neutralizing the action of POISONS. (See all compounds classified as Antidotes.)

    Antineoplastic Agents

    Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

    Antioxidants

    Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)

    Anti-Arrhythmia Agents

    Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)