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    Tinoridine

    ACTIVE PHARMA INGREDIENTS

    INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: 24237-54-5, Ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate, Nonflamin (free base), Tinoridine [inn], Y 3642, Y-3642
    Molecular Formula
    C17H20N2O2S
    Molecular Weight
    316.4  g/mol
    InChI Key
    PFENFDGYVLAFBR-UHFFFAOYSA-N
    FDA UNII
    C9Z9ICZ7YR
    Tinoridine is under investigation in clinical trial NCT01224756 (Efficacy of Tinoridine in Treating Pain and Inflammation in Adults).
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    ethyl 2-amino-6-benzyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate
    2.1.2 InChI
    InChI=1S/C17H20N2O2S/c1-2-21-17(20)15-13-8-9-19(11-14(13)22-16(15)18)10-12-6-4-3-5-7-12/h3-7H,2,8-11,18H2,1H3
    2.1.3 InChI Key
    PFENFDGYVLAFBR-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCOC(=O)C1=C(SC2=C1CCN(C2)CC3=CC=CC=C3)N
    2.2 Other Identifiers
    2.2.1 UNII
    C9Z9ICZ7YR
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)-pyridine-3-carboxylic Acid Ethyl Ester

    2. Nonflamin

    3. Nonflamine

    4. Tinoridin

    5. Tinoridine Hydrochloride

    6. Tinoridine Monohydrochloride

    7. Y 3642

    8. Y-3642

    2.3.2 Depositor-Supplied Synonyms

    1. 24237-54-5

    2. Ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate

    3. Nonflamin (free Base)

    4. Tinoridine [inn]

    5. Y 3642

    6. Y-3642

    7. Nsc 158555

    8. C9z9icz7yr

    9. Nsc-158555

    10. Ethyl 2-amino-6-benzyl-5,7-dihydro-4h-thieno[2,3-c]pyridine-3-carboxylate

    11. Chembl592943

    12. Dtxsid9023677

    13. Tinoridine (inn)

    14. 2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridine

    15. Ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridine-3-carboxylate

    16. Ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno-[2,3-c]pyridine-3-carboxylate

    17. 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridine-3-carboxylic Acid Ethyl Ester

    18. Ncgc00159451-02

    19. Ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno [2,3-c]pyridine-3-carboxylate

    20. Thieno(2,3-c)pyridine-3-carboxylic Acid, 2-amino-6-benzyl-4,5,6,7-tetrahydro-, Ethyl Ester

    21. Thieno[2,3-c]pyridine-3-carboxylic Acid, 2-amino-4,5,6,7-tetrahydro-6-(phenylmethyl)-, Ethyl Ester

    22. Dtxcid403677

    23. Tinoridino

    24. Tinoridinum

    25. Tinoridinum [inn-latin]

    26. Tinoridino [inn-spanish]

    27. 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic Acid Ethyl Ester

    28. Ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (tinoridine)

    29. Thieno(2,3-c)pyridine-3-carboxylic Acid, 2-amino-4,5,6,7-tetrahydro-6-(phenylmethyl)-, Ethyl Ester

    30. Cas-24237-54-5

    31. Einecs 246-102-0

    32. Unii-c9z9icz7yr

    33. Brn 1082341

    34. Tinoridine [mi]

    35. Maybridge2_000001

    36. Cbmicro_018439

    37. 2-amino-3-aethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridin

    38. 2-amino-3-aethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridin [german]

    39. Tinoridine [who-dd]

    40. Oprea1_041651

    41. Oprea1_798781

    42. Schembl24761

    43. Mls004774001

    44. Chebi:135353

    45. Pfenfdgyvlafbr-uhfffaoysa-n

    46. Hms1303a01

    47. Bcp12825

    48. Ccg-6706

    49. Tox21_111678

    50. Bdbm50304470

    51. Mfcd00401417

    52. Nsc158555

    53. Akos000267028

    54. Tox21_111678_1

    55. Db13001

    56. Hy-w032848

    57. 2-amino-6-benzyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic Acid Ethyl Ester

    58. Idi1_001041

    59. Thieno(2,3-c)pyridine-3-carboxylic Acid, 4,5,6,7-tetrahydro-2-amino-6-benzyl-, Ethyl Ester

    60. Ncgc00159451-03

    61. Ncgc00159451-04

    62. Ncgc00159451-05

    63. Ncgc00159451-06

    64. Ac-27457

    65. As-35595

    66. Smr000103196

    67. Bim-0018431.p001

    68. Cs-0076872

    69. Ft-0645518

    70. Ns00027593

    71. En300-03920

    72. D08602

    73. J-015409

    74. J-524972

    75. Sr-01000644920-1

    76. Q27275368

    77. Z56176137

    78. F1673-2635

    79. Thieno[2, 2-amino-6-benzyl-4,5,6,7-tetrahydro-, Ethyl Ester

    80. Ethyl 2-amino-6-benzyl-4h,5h,6h,7h-thieno[2,3-c]pyridine-3-carboxylate

    81. Thieno[2, 2-amino-4,5,6,7-tetrahydro-6-(phenylmethyl)-, Ethyl Ester

    82. Ethyl 2-amino-6-(phenylmethyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate

    83. Ethyl 2-amino-6-benzyl-5, 7-dihydro-4h-thieno[2, 3-c]pyridine-3-carboxylate

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 316.4 g/mol
    Molecular Formula C17H20N2O2S
    XLogP33.4
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count5
    Exact Mass g/mol
    Monoisotopic Mass g/mol
    Topological Polar Surface Area83.8
    Heavy Atom Count22
    Formal Charge0
    Complexity387
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents, Non-Steroidal

    Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)