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    Tocainide

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    REF. STANDARDS & IMPURITIES

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    2D Structure
    Also known as: 71395-14-7, Tocainide hcl, 35891-93-1, Tonocard, Tocainide monohydrochloride, 2-amino-n-(2,6-dimethylphenyl)propanamide;hydrochloride
    Molecular Formula
    C11H17ClN2O
    Molecular Weight
    228.72  g/mol
    InChI Key
    AMZACPWEJDQXGW-UHFFFAOYSA-N
    FDA UNII
    2K7I38CKN5
    An antiarrhythmic agent which exerts a potential- and frequency-dependent block of SODIUM CHANNELS.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-amino-N-(2,6-dimethylphenyl)propanamide;hydrochloride
    2.1.2 InChI
    InChI=1S/C11H16N2O.ClH/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12;/h4-6,9H,12H2,1-3H3,(H,13,14);1H
    2.1.3 InChI Key
    AMZACPWEJDQXGW-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=C(C(=CC=C1)C)NC(=O)C(C)N.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    2K7I38CKN5
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Hydrochloride, Tocainide

    2. Tocainide

    3. Tocainide Monohdyrochloride, (r)-isomer

    4. Tocainide Monohydrobromide, (r)-isomer

    5. Tocainide Monohydrochloride

    6. Tocainide Monohydrochloride, (+-)-isomer

    7. Tocainide Monohydrochloride, (s)-isomer

    8. Tocainide, (+-)-isomer

    9. Tocainide, (r)-isomer

    10. Tocainide, (s)-isomer

    11. Tonocard

    12. W 36095

    13. W-36095

    14. W36095

    15. Xylotocan

    2.3.2 Depositor-Supplied Synonyms

    1. 71395-14-7

    2. Tocainide Hcl

    3. 35891-93-1

    4. Tonocard

    5. Tocainide Monohydrochloride

    6. 2-amino-n-(2,6-dimethylphenyl)propanamide;hydrochloride

    7. 2-amino-n-(2,6-dimethylphenyl)propanamide Hydrochloride

    8. Tocainide Hydrochloride [usp]

    9. 2k7i38ckn5

    10. Tocainide (hydrochloride)

    11. Propanamide, 2-amino-n-(2,6-dimethylphenyl)-, Monohydrochloride

    12. Dsstox_cid_25540

    13. Dsstox_rid_80942

    14. Dsstox_gsid_45540

    15. Tocainide Hydrochloride (usp)

    16. Taquidil

    17. Xylotocan

    18. Cas-35891-93-1

    19. Tocainide-hydrochloride

    20. Unii-2k7i38ckn5

    21. Tonocard (tn)

    22. Einecs 275-361-2

    23. 2-amino-n-(2,6-dimethylphenyl)propanamide Monohydrochloride

    24. Ncgc00017005-01

    25. 2-amino-2',6'-propionoxylidide Hydrochloride

    26. Schembl122779

    27. Tocainide Hydrochloride- Bio-x

    28. Chembl1200773

    29. Dtxsid5045540

    30. Hy-b1798a

    31. Hms1571m15

    32. Tocainide (+-)-form Hydrochloride

    33. Tox21_110732

    34. Tox21_500344

    35. Tox21_110732_1

    36. Ccg-213604

    37. Lp00344

    38. Tocainide Hydrochloride [mart.]

    39. Tocainide Hydrochloride [vandf]

    40. Tocainide Hydrochloride [who-dd]

    41. Ncgc00162129-06

    42. Ncgc00261029-01

    43. Bt164480

    44. Tocainide (+/-)-form Hydrochloride

    45. Cs-0013838

    46. Tocainide Hydrochloride [orange Book]

    47. Tocainide Hydrochloride [usp Impurity]

    48. D02088

    49. 6-bromo-4-quinazolinecarboxylic Acidammonium Salt

    50. Tocainide Hydrochloride, >=98% (hplc), Solid

    51. Sr-01000763682

    52. Tocainide (+/-)-form Hydrochloride [mi]

    53. Sr-01000763682-3

    54. Q27254865

    55. (1)-2-amino-n-(2,6-dimethylphenyl)propionamide Hydrochloride

    56. Propanamide, 2-amino-n-(2,6-dimethylphenyl)-, Monohydrochloride, (+-)-

    57. Tocainide Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 228.72 g/mol
    Molecular Formula C11H17ClN2O
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count2
    Exact Mass228.1029409 g/mol
    Monoisotopic Mass228.1029409 g/mol
    Topological Polar Surface Area55.1 Ų
    Heavy Atom Count15
    Formal Charge0
    Complexity196
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Arrhythmia Agents

    Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

    Voltage-Gated Sodium Channel Blockers

    A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS. (See all compounds classified as Voltage-Gated Sodium Channel Blockers.)