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    Todralazine

    PharmaCompass
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    2D Structure
    Also known as: 14679-73-3, Todralacina, Todralazina, Ecarazine, Carboethoxyphthalazinohydrazine, Ethyl 3-(1-phthalazinyl)carbazate
    Molecular Formula
    C11H12N4O2
    Molecular Weight
    232.24  g/mol
    InChI Key
    WGZDBVOTUVNQFP-UHFFFAOYSA-N
    FDA UNII
    WEN3K83YKD
    An antihypertensive agent with both central and peripheral action; it has some central nervous system depressant effects.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    ethyl N-(phthalazin-1-ylamino)carbamate
    2.1.2 InChI
    InChI=1S/C11H12N4O2/c1-2-17-11(16)15-14-10-9-6-4-3-5-8(9)7-12-13-10/h3-7H,2H2,1H3,(H,13,14)(H,15,16)
    2.1.3 InChI Key
    WGZDBVOTUVNQFP-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCOC(=O)NNC1=NN=CC2=CC=CC=C21
    2.2 Other Identifiers
    2.2.1 UNII
    WEN3K83YKD
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Apirachol

    2. Binazin

    3. Binazine

    4. Ecarazine

    5. Todrazoline

    2.3.2 Depositor-Supplied Synonyms

    1. 14679-73-3

    2. Todralacina

    3. Todralazina

    4. Ecarazine

    5. Carboethoxyphthalazinohydrazine

    6. Ethyl 3-(1-phthalazinyl)carbazate

    7. Bt 621

    8. Carbazic Acid, 3-(1-phthalazinyl)-, Ethyl Ester

    9. 3-(1-phthalazinyl)carbazic Acid Ethyl Ester

    10. Hydrazinecarboxylic Acid, 2-(1-phthalazinyl)-, Ethyl Ester

    11. Wen3k83ykd

    12. Ceph [as Hydrochloride]

    13. Binazin

    14. Bt 621 [as Hydrochloride]

    15. Nsc-757868

    16. Todralacina [spanish]

    17. Todralazinum

    18. Todralazine [inn:ban]

    19. Todralazinum [inn-latin]

    20. Todralazina [inn-spanish]

    21. Ncgc00016640-03

    22. Unii-wen3k83ykd

    23. Cas-3778-76-5

    24. N-carboethoxy-n'-phthalazino-hydrazine

    25. Brn 0233300

    26. Todralazine (ban)

    27. Ceph

    28. Binazine (salt/mix)

    29. Ethyl N-(phthalazin-1-ylamino)carbamate

    30. Ecarazine (salt/mix)

    31. Ceph Free Base

    32. Spectrum_001187

    33. Todrazoline (salt/mix)

    34. Todralazine [mi]

    35. Prestwick0_000071

    36. Prestwick1_000071

    37. Prestwick2_000071

    38. Prestwick3_000071

    39. Spectrum2_001147

    40. Spectrum3_000932

    41. Spectrum4_001031

    42. Spectrum5_001223

    43. Todralazine [inn]

    44. Bt-621 Free Base

    45. Schembl49644

    46. Bspbio_000281

    47. Kbiogr_001581

    48. Kbioss_001667

    49. Todralazine [who-dd]

    50. 5-25-17-00414 (beilstein Handbook Reference)

    51. Divk1c_000506

    52. Spbio_001073

    53. Spbio_002202

    54. Bpbio1_000311

    55. Chembl1079787

    56. Dtxsid0045048

    57. Chebi:94706

    58. Kbio1_000506

    59. Kbio2_001667

    60. Kbio2_004235

    61. Kbio2_006803

    62. Kbio3_001964

    63. Ninds_000506

    64. Hy-b1001

    65. Zinc18055768

    66. Cs-4498

    67. Nsc 757868

    68. Idi1_000506

    69. Ncgc00016640-01

    70. Ncgc00016640-02

    71. 1-(n'-ethoxycarbonylhydrazino)phthalazine

    72. Da-10133

    73. Sbi-0051674.p002

    74. Ab00053609

    75. Ft-0737585

    76. D08613

    77. Ethyl 2-(1-phthalazinyl)hydrazinecarboxylate #

    78. Ab00053609_08

    79. N-(1-phthalazinylamino)carbamic Acid Ethyl Ester

    80. Cu-00000000398-1

    81. Brd-k68553471-003-04-0

    82. Brd-k68553471-003-07-3

    83. Q27166508

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 232.24 g/mol
    Molecular Formula C11H12N4O2
    XLogP31.7
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count4
    Exact Mass232.09602564 g/mol
    Monoisotopic Mass232.09602564 g/mol
    Topological Polar Surface Area76.1 Ų
    Heavy Atom Count17
    Formal Charge0
    Complexity262
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)