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    TOLAZOLINE HYDROCHLORIDE

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    RELATED EXCIPIENT COMPANIES

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    2D Structure
    Also known as: 59-97-2, Tolazoline hcl, 2-benzyl-4,5-dihydro-1h-imidazole hydrochloride, Priscoline, 2-benzyl-2-imidazoline hydrochloride, Tolazoline (hydrochloride)
    Molecular Formula
    C10H13ClN2
    Molecular Weight
    196.67  g/mol
    InChI Key
    RHTNTTODYGNRSP-UHFFFAOYSA-N
    FDA UNII
    E669Z6S1JG
    A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-benzyl-4,5-dihydro-1H-imidazole;hydrochloride
    2.1.2 InChI
    InChI=1S/C10H12N2.ClH/c1-2-4-9(5-3-1)8-10-11-6-7-12-10;/h1-5H,6-8H2,(H,11,12);1H
    2.1.3 InChI Key
    RHTNTTODYGNRSP-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CN=C(N1)CC2=CC=CC=C2.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    E669Z6S1JG
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Benzalolin

    2. Divascol

    3. Pridazole

    4. Priscol

    5. Priscoline

    6. Tolazoline

    7. Tolazoline Monohydrochloride

    2.3.2 Depositor-Supplied Synonyms

    1. 59-97-2

    2. Tolazoline Hcl

    3. 2-benzyl-4,5-dihydro-1h-imidazole Hydrochloride

    4. Priscoline

    5. 2-benzyl-2-imidazoline Hydrochloride

    6. Tolazoline (hydrochloride)

    7. Imidaline Hydrochloride

    8. Benzazoline Hydrochloride

    9. 1h-imidazole, 4,5-dihydro-2-(phenylmethyl)-, Monohydrochloride

    10. 2-benzyl-2-imidazoline Monohydrochloride

    11. 2-imidazoline, 2-benzyl-, Hydrochloride

    12. Ai3-52042

    13. Tcmdc-125842

    14. Nsc-757353

    15. 2-benzyl-2-imidazoline Hcl

    16. Mls000559484

    17. E669z6s1jg

    18. 2-benzyl-4,5-dihydro-1h-imidazole;hydrochloride

    19. Arterodyl

    20. Smr000149600

    21. Tolavad

    22. Tolpal

    23. 1h-imidazole, 4,5-dihydro-2-(phenylmethyl)-, Hydrochloride (1:1)

    24. Priscoline Hydrochloride

    25. Dsstox_cid_1718

    26. Dsstox_rid_76292

    27. Tolazoline Chloride

    28. Dsstox_gsid_21718

    29. Imidaline (hydrochloride); Nsc35110 (hydrochloride)

    30. Benzylimidazoline Hydrochloride

    31. Tolazoline Hydrochloride [jan]

    32. Cas-59-97-2

    33. Ncgc00016271-01

    34. Einecs 200-447-3

    35. Unii-e669z6s1jg

    36. Sr-01000665661

    37. Priscoline (tn)

    38. Cloridrato Di 2-benzil-4,5-imidazolina [italian]

    39. Prestwick_770

    40. Tolazoline Hydrochloride [usp:jan]

    41. Mfcd00012693

    42. Benzidazol Hydrochloride

    43. Cloridrato Di 2-benzil-4,5-imidazolina

    44. 4,5-dihydro-2-(phenylmethyl)-1h-imidazole Monohydrochloride

    45. Imidaline (hydrochloride)

    46. Opera_id_1028

    47. Chembl1689

    48. Schembl34869

    49. Nsc35110 (hydrochloride)

    50. Tolazoline Hydrochloride,(s)

    51. Spectrum1500580

    52. 2-imidazoline, 2-benzyl-, Monohydrochloride

    53. Chebi:9615

    54. 2-(phenylmethyl)-4,5-dihydro-1h-imidazole Hydrochloride

    55. Dtxsid9021718

    56. Hy-a0066a

    57. Hms1568k21

    58. Hms1921e17

    59. Pharmakon1600-01500580

    60. Amy13632

    61. Tolazoline Hydrochloride (jan/usp)

    62. Tox21_110339

    63. Ccg-39122

    64. Nsc757353

    65. S4124

    66. Tolazoline Hydrochloride [mi]

    67. Akos015900184

    68. Akos028109640

    69. Tox21_110339_1

    70. Cs-4287

    71. Ks-5261

    72. Nc00612

    73. Nsc 757353

    74. Tolazoline Hydrochloride [mart.]

    75. Tolazoline Hydrochloride [vandf]

    76. Ncgc00016271-05

    77. Ncgc00094795-01

    78. Ncgc00094795-02

    79. Tolazoline Hydrochloride [usp-rs]

    80. Tolazoline Hydrochloride [who-dd]

    81. Db-014037

    82. Ft-0601730

    83. Sw196909-3

    84. T3791

    85. Tolazoline Hydrochloride [green Book]

    86. Tolazoline Hydrochloride [orange Book]

    87. D00997

    88. E77029

    89. Imidaline Hydrochloride;benzidazol Hydrochloride

    90. Tolazoline Hydrochloride [usp Monograph]

    91. Sr-01000665661-3

    92. Q27276930

    93. Z1550648768

    94. 2-benzyl-2-imidazoline Hydrochloride,2-benzyl-2-imidazoline

    95. Tolazoline Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    96. Tolazoline Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 196.67 g/mol
    Molecular Formula C10H13ClN2
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count1
    Rotatable Bond Count2
    Exact Mass196.0767261 g/mol
    Monoisotopic Mass196.0767261 g/mol
    Topological Polar Surface Area24.4 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity169
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Vasodilator Agents

    Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

    Adrenergic alpha-Antagonists

    Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. (See all compounds classified as Adrenergic alpha-Antagonists.)