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    Technical details about Tolperisone, learn more about the structure, uses, toxicity, action, side effects and more

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    Tolperisone

    APIs // Active Pharmaceutical Ingredients

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    2D Structure
    1. Also known as: 3644-61-9, Tolperisone hcl, Midocalm, Muscalm, Tolperisone (hydrochloride), 2,4'-dimethyl-3-piperidinopropiophenone hydrochloride
    Molecular Formula
    C16H24ClNO
    Molecular Weight
    281.82  g/mol
    InChI Key
    ZBUVYROEHQQAKL-UHFFFAOYSA-N
    FDA UNII
    8Z075K2TIG
    A centrally acting muscle relaxant that has been used for the symptomatic treatment of spasticity and muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1211)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one;hydrochloride
    2.1.2 InChI
    InChI=1S/C16H23NO.ClH/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17;/h6-9,14H,3-5,10-12H2,1-2H3;1H
    2.1.3 InChI Key
    ZBUVYROEHQQAKL-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=CC=C(C=C1)C(=O)C(C)CN2CCCCC2.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    8Z075K2TIG
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Hydrochloride, Tolperisone

    2. Midocalm

    3. Mydeton

    4. Mydocalm

    5. Tolperisone

    2.3.2 Depositor-Supplied Synonyms

    1. 3644-61-9

    2. Tolperisone Hcl

    3. Midocalm

    4. Muscalm

    5. Tolperisone (hydrochloride)

    6. 2,4'-dimethyl-3-piperidinopropiophenone Hydrochloride

    7. 2-methyl-3-piperidino-1-p-tolylpropan-1-one Hydrochloride

    8. Tolperisone Hydrochloride [jan]

    9. 2-methyl-1-(4-methylphenyl)-3-(piperidin-1-yl)propan-1-one Hydrochloride

    10. N-553

    11. 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone Hydrochloride

    12. 3644-61-9 (hcl)

    13. 8z075k2tig

    14. 1-piperidino-2-methyl-3-(p-tolyl)-3-propanone Hydrochloride

    15. Ncgc00094929-01

    16. Dsstox_cid_25868

    17. Dsstox_rid_81187

    18. Dsstox_gsid_45868

    19. Arantoick

    20. Atmosgen

    21. Besnoline

    22. Isocalm

    23. Kineorl

    24. Metosomin

    25. Abbsa

    26. 2-methyl-3-(piperidin-1-yl)-1-p-tolylpropan-1-one Hydrochloride

    27. 2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one;hydrochloride

    28. Cas-3644-61-9

    29. Tolperisonehydrochloride

    30. Einecs 222-876-5

    31. Av 650

    32. Unii-8z075k2tig

    33. 1-propanone, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-, Hydrochloride

    34. Muscalm (tn)

    35. Mfcd00058211

    36. Biocalm

    37. Minacalm

    38. Naismeritin

    39. Tolfree

    40. Tolisartine

    41. Tolpidol

    42. Ncgc00182078-02

    43. Mls004773941

    44. Schembl872770

    45. Spectrum1501194

    46. 2,4'-dimethyl-3-piperidino-propiophenone Hydrochloride

    47. Chembl1395150

    48. Dtxsid2045868

    49. Chebi:32244

    50. Propiophenone, 2,4'-dimethyl-3-piperidino-, Hydrochloride

    51. Tolperisone Hydrochloride (jp17)

    52. Hms1921p09

    53. Pharmakon1600-01501194

    54. Hy-b1139

    55. Tox21_111360

    56. Tox21_113139

    57. Ccg-40311

    58. Nsc757872

    59. S4200

    60. Tolperisone Hydrochloride [mi]

    61. 2-methyl-1-(4-methylphenyl)-3-(1-piperidyl)propan-1-one Hydrochloride

    62. Akos005167032

    63. Tox21_111360_1

    64. Ac-4685

    65. Cs-4744

    66. Ncgc00094929-02

    67. Ncgc00178060-03

    68. Tolperisone Hydrochloride [mart.]

    69. As-12472

    70. Bp-10588

    71. Smr003500666

    72. Tolperisone Hydrochloride [who-dd]

    73. Ft-0603642

    74. Ft-0675274

    75. Sw219278-1

    76. T1319

    77. A18694

    78. D01507

    79. H12066

    80. 644t619

    81. Sr-01000872774

    82. Tolperisone Hydrochloride, >=98% (hplc), Solid

    83. Sr-01000872774-1

    84. W-106614

    85. Q27271220

    86. F9995-4198

    87. 2-methyl-3-(piperidin-1-yl)-1-(p-tolyl)propan-1-one Hydrochloride

    88. 1-propanone, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-, Hydrochloride (1:1)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 281.82 g/mol
    Molecular Formula C16H24ClNO
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count4
    Exact Mass281.1546421 g/mol
    Monoisotopic Mass281.1546421 g/mol
    Topological Polar Surface Area20.3 Ų
    Heavy Atom Count19
    Formal Charge0
    Complexity262
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Muscle Relaxants, Central

    A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)

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