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    Trifluoperazine Hydrochloride

    ACTIVE PHARMA INGREDIENTS

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    2D Structure
    Also known as: Cpd000059133, Mls000069471, Fluoperazine, Calmazine, Smr000059133, Stalazine hydrochloride
    Molecular Formula
    C21H25ClF3N3S
    Molecular Weight
    444.0  g/mol
    InChI Key
    RIULCFSTKRDHBX-UHFFFAOYSA-N
    A phenothiazine with actions similar to CHLORPROMAZINE. It is used as an antipsychotic and an antiemetic.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride
    2.1.2 InChI
    InChI=1S/C21H24F3N3S.ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;/h2-3,5-8,15H,4,9-14H2,1H3;1H
    2.1.3 InChI Key
    RIULCFSTKRDHBX-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F.Cl
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Apo Trifluoperazine

    2. Apo-trifluoperazine

    3. Apotrifluoperazine

    4. Flupazine

    5. Stelazine

    6. Terfluzine

    7. Trifluoperazine

    8. Trifluoperazine Hcl

    9. Trifluoperazine Hydrochloride

    10. Trifluoroperazine

    11. Trifluperazine

    12. Triftazin

    2.2.2 Depositor-Supplied Synonyms

    1. Cpd000059133

    2. Mls000069471

    3. Fluoperazine

    4. Calmazine

    5. Smr000059133

    6. Stalazine Hydrochloride

    7. 10h-phenothiazine,10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, Hydrochloride (1:2)

    8. Stelazine Dihydrochloride

    9. Trifluperazine Dihydrochloride

    10. Mls001146870

    11. Mls002702821

    12. Trifluoroperazine Dihydrochloride

    13. 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride

    14. 10-[3-(4-methylpiperazinyl)propyl]-2-(trifluoromethyl)phenothiazine, Chloride, Chloride

    15. Nsc17474

    16. Skf 5019

    17. Eskazine Dihydrochloride

    18. Triflurin Dihydrochloride

    19. Opera_id_1296

    20. Trifluoperazine Hydrochoride

    21. Chembl1710

    22. Schembl41194

    23. Tripfluoperazine Hydrochloride

    24. Mls000758242

    25. Mls001423986

    26. Mls002222216

    27. Triflorperazine Dihydrochloride

    28. Trifluoropyrazin Dihydrochloride

    29. Pharmakon1600-01500591

    30. Nsc757369

    31. Akos016395836

    32. Ccg-100803

    33. Nc00053

    34. Ncgc00180883-01

    35. Ncgc00180883-02

    36. Wln: T C666 Bn Isj Exfff B3- At6n Dntj D1 &gh 2

    2.3 Create Date
    2005-07-29
    3 Chemical and Physical Properties
    Molecular Weight 444.0 g/mol
    Molecular Formula C21H25ClF3N3S
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count4
    Exact Mass443.1409812 g/mol
    Monoisotopic Mass443.1409812 g/mol
    Topological Polar Surface Area35 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity510
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antiemetics

    Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

    Dopamine Antagonists

    Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)