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    Technical details about Trifluperidol, learn more about the structure, uses, toxicity, action, side effects and more

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    Trifluperidol

    APIs // Active Pharmaceutical Ingredients

    INTERMEDIATES

    DOSSIERs // Finished Dosage Forms

    PharmaCompass

    Farmhispania Group, a leading European CDMO in HPAPI Technologies & High Potency Fermentation.

    One Pharma aims to be one of the leading generic companies in Europe.

    2D Structure
    1. Also known as: 749-13-3, Triperidol, Trisedil, Psychoperidol, Flumoperone, Psicoperidol
    Molecular Formula
    C22H23F4NO2
    Molecular Weight
    409.4  g/mol
    InChI Key
    GPMXUUPHFNMNDH-UHFFFAOYSA-N
    FDA UNII
    R8869Q7R8I
    A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in the treatment of PSYCHOSES including MANIA and SCHIZOPHRENIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p621)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]butan-1-one
    2.1.2 InChI
    InChI=1S/C22H23F4NO2/c23-19-8-6-16(7-9-19)20(28)5-2-12-27-13-10-21(29,11-14-27)17-3-1-4-18(15-17)22(24,25)26/h1,3-4,6-9,15,29H,2,5,10-14H2
    2.1.3 InChI Key
    GPMXUUPHFNMNDH-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CN(CCC1(C2=CC(=CC=C2)C(F)(F)F)O)CCCC(=O)C3=CC=C(C=C3)F
    2.2 Other Identifiers
    2.2.1 UNII
    R8869Q7R8I
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Trisedil

    2.3.2 Depositor-Supplied Synonyms

    1. 749-13-3

    2. Triperidol

    3. Trisedil

    4. Psychoperidol

    5. Flumoperone

    6. Psicoperidol

    7. Trisedyl

    8. Psicoperidol-r

    9. Mcn-jr-2498

    10. Trifluperidolo

    11. R-2498

    12. Nsc 170978

    13. P 459

    14. 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]butan-1-one

    15. Nsc-170978

    16. Chembl15023

    17. 1-butanone, 1-(4-fluorophenyl)-4-(4-hydroxy-4-(3-(trifluoromethyl)phenyl)-1-piperidinyl)-

    18. R8869q7r8i

    19. Nsc170978

    20. Triperidol (tn)

    21. 4-fluoro-4,4-idrossi-4-(m-trifluorometil-fenil)-piperidino-butirrofenone

    22. Trifluperidolum

    23. Trifluperidolo [dcit]

    24. Trifluperidolo [italian]

    25. 1-(4-fluorophenyl)-4-(4-hydroxy-4-(3-(trifluoromethyl)phenyl)piperidin-1-yl)butan-1-one

    26. 1-butanone, 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-

    27. Trifluperidolum [inn-latin]

    28. Butyrophenone, 4'-fluoro-4-(4-hydroxy-4-(.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)piperidino)-

    29. Butyrophenone, 4'-fluoro-4-[4-hydroxy-4-(.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)piperidino]-

    30. Trifluperidol [usan:inn:ban]

    31. Brn 1556208

    32. Unii-r8869q7r8i

    33. .psi.coperidol

    34. 1-(4-fluorophenyl)-4-{4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-1-yl}butan-1-one

    35. .psi.coperidol-r

    36. 4'-fluoro-4-(4-hydroxy-4-(.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)piperidino)butyrophenone

    37. 4'-fluoro-4-[4-hydroxy-4-(.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)piperidino]butyrophenone

    38. Lopac-t-103

    39. Trifluperidol [mi]

    40. Trifluperidol [inn]

    41. Trifluperidol (usan/inn)

    42. 4'-fluoro-4-(4-hydroxy-4-(alpha,alpha,alpha-trifluoro-m-tolyl)piperidino)butyrophenone

    43. 4-fluoro-4,4-idrossi-4-(m-trifluorometil-fenil)-piperidino-butirrofenone [italian]

    44. Trifluperidol [usan]

    45. Lopac0_001243

    46. 5-21-02-00406 (beilstein Handbook Reference)

    47. Schembl120862

    48. Trifluperidol [mart.]

    49. Trifluperidol [who-dd]

    50. Dtxsid4023703

    51. Chebi:135662

    52. Hms2090p16

    53. Bcp28492

    54. Bdbm50047016

    55. Ccg-205317

    56. Db13552

    57. Sdccgsbi-0051210.p002

    58. Butyrophenone, 4'-fluoro-4-(4-hydroxy-4-(alpha,alpha,alpha-trifluoro-m-tolyl)piperidino)-

    59. Ncgc00015983-01

    60. Ncgc00015983-02

    61. Ncgc00015983-03

    62. Ncgc00015983-06

    63. Ncgc00162376-01

    64. Wln: T6ntj A3vr Df& Dq Dr Cxfff

    65. 1st161655

    66. Ns00010654

    67. D02625

    68. Ab00918346-05

    69. L001285

    70. Q4463264

    71. Brd-k43605761-003-05-4

    72. R-2498; R 2498; R2498

    73. Butyrophenone,.alpha.,.alpha.-trifluoro-m-tolyl)piperidino]-

    74. 1-(4-fluoro-phenyl)-4-[4-hydroxy-4-(3-trifluoromethyl-phenyl)-piperidin-1-yl]-butan-1-one

    75. 1-(4-fluorophenyl)-4-(4-hydroxy-4-(3-(trifluoromethyl)phenyl)-1-piperidinyl)-1-butanone

    76. 1-(4-fluorophenyl)-4-(4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl)-1-butanone #

    77. 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidyl]-butan-1-one

    78. 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidyl]butan-1-one

    79. 4'-fluoro-4-[4-hydroxy-4-(.alpha.,.alpha.-trifluoro-m-tolyl)piperidino]butyrophenone

    80. 1-(4-fluoro-phenyl)-4-[4-hydroxy-4-(3-trifluoromethyl-phenyl)-piperidin-1-yl]-butan-1-one (trifluperidol)

    81. 1-butanone, 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-pi Peridinyl]-

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 409.4 g/mol
    Molecular Formula C22H23F4NO2
    XLogP33.5
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count6
    Exact Mass g/mol
    Monoisotopic Mass g/mol
    Topological Polar Surface Area40.5
    Heavy Atom Count29
    Formal Charge0
    Complexity537
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

    Dopamine Antagonists

    Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

    4.2 ATC Code

    N - Nervous system

    N05 - Psycholeptics

    N05A - Antipsychotics

    N05AD - Butyrophenone derivatives

    N05AD02 - Trifluperidol

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