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    Tripamide

    ACTIVE PHARMA INGREDIENTS

    PharmaCompass
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    2D Structure
    Also known as: Tripamide, 73803-48-2, N-[(1s,2r,6s,7r)-4-azatricyclo[5.2.1.02,6]decan-4-yl]-4-chloro-3-sulfamoylbenzamide, Normonal (tn), Schembl49666, Tripamide (jan/usan/inn)
    Molecular Formula
    C16H20ClN3O3S
    Molecular Weight
    369.9  g/mol
    InChI Key
    UHLOVGKIEARANS-QZHINBJYSA-N
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-[(1S,2R,6S,7R)-4-azatricyclo[5.2.1.02,6]decan-4-yl]-4-chloro-3-sulfamoylbenzamide
    2.1.2 InChI
    InChI=1S/C16H20ClN3O3S/c17-14-4-3-11(6-15(14)24(18,22)23)16(21)19-20-7-12-9-1-2-10(5-9)13(12)8-20/h3-4,6,9-10,12-13H,1-2,5,7-8H2,(H,19,21)(H2,18,22,23)/t9-,10+,12+,13-
    2.1.3 InChI Key
    UHLOVGKIEARANS-QZHINBJYSA-N
    2.1.4 Canonical SMILES
    C1CC2CC1C3C2CN(C3)NC(=O)C4=CC(=C(C=C4)Cl)S(=O)(=O)N
    2.1.5 Isomeric SMILES
    C1C[C@H]2C[C@@H]1[C@H]3[C@@H]2CN(C3)NC(=O)C4=CC(=C(C=C4)Cl)S(=O)(=O)N
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. E 614

    2. E614

    3. N-(4-azo-endo-tricyclo(5.2.1.0.(2.6))-decan)-4-chloro-3-sulfamoylbenzamide

    4. Tripamide

    2.2.2 Depositor-Supplied Synonyms

    1. Tripamide

    2. 73803-48-2

    3. N-[(1s,2r,6s,7r)-4-azatricyclo[5.2.1.02,6]decan-4-yl]-4-chloro-3-sulfamoylbenzamide

    4. Normonal (tn)

    5. Schembl49666

    6. Tripamide (jan/usan/inn)

    7. Chembl2104484

    8. Zinc1481940

    9. D01895

    10. Q7843228

    11. Benzamide, 3-(aminosulfonyl)-4-chloro-n-[(3ar,4r,7s,7as)-octahydro-4,7-methano-2h-isoindol-2-yl]-, Rel-

    2.3 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 369.9 g/mol
    Molecular Formula C16H20ClN3O3S
    XLogP32.6
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count3
    Exact Mass369.0913904 g/mol
    Monoisotopic Mass369.0913904 g/mol
    Topological Polar Surface Area101 Ų
    Heavy Atom Count24
    Formal Charge0
    Complexity605
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Sodium Potassium Chloride Symporter Inhibitors

    Agents that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS which are concentrated in the thick ascending limb at the junction of the LOOP OF HENLE and KIDNEY TUBULES, DISTAL. They act as DIURETICS. Excess use is associated with HYPOKALEMIA and HYPERGLYCEMIA. (See all compounds classified as Sodium Potassium Chloride Symporter Inhibitors.)