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2D Structure
Also known as: 550-70-9, Actidilat, Venen, Actidil, Trans-triprolidine hydrochloride, Pro-actidil
Molecular Formula
C19H23ClN2
Molecular Weight
314.9  g/mol
InChI Key
WYUYEJNGHIOFOC-NWBUNABESA-N
FDA UNII
NG7A104R3J

Histamine H1 antagonist used in allergic rhinitis; ASTHMA; and URTICARIA. It is a component of COUGH and COLD medicines. It may cause drowsiness.
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine;hydrochloride
2.1.2 InChI
InChI=1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;
2.1.3 InChI Key
WYUYEJNGHIOFOC-NWBUNABESA-N
2.1.4 Canonical SMILES
CC1=CC=C(C=C1)C(=CCN2CCCC2)C3=CC=CC=N3.Cl
2.1.5 Isomeric SMILES
CC1=CC=C(C=C1)/C(=C\CN2CCCC2)/C3=CC=CC=N3.Cl
2.2 Other Identifiers
2.2.1 UNII
NG7A104R3J
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Actidil

2. Anhydrous, Triprolidine Hydrochloride

3. Hydrochloride Anhydrous, Triprolidine

4. Hydrochloride, Triprolidine

5. Pro Actidil

6. Triprolidine

7. Triprolidine Hydrochloride Anhydrous

8. Triprolidine Monohydrochloride

9. Triprolidine Monohydrochloride, (z)-isomer

10. Triprolidine Monohydrochloride, Monohydrate

11. Triprolidine Oxalate

12. Triprolidine Oxalate, (trans)-isomer

13. Triprolidine, (z)-isomer

2.3.2 Depositor-Supplied Synonyms

1. 550-70-9

2. Actidilat

3. Venen

4. Actidil

5. Trans-triprolidine Hydrochloride

6. Pro-actidil

7. Pro-entra

8. Triprolidine Hydrochloride Anhydrous

9. 6138-79-0

10. Entra

11. (e)-2-(3-(pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine Hydrochloride

12. Triprolidine Hydrochloride (anhydrous)

13. Mls000028751

14. Ng7a104r3j

15. Chebi:84119

16. Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, Monohydrochloride, (e)-

17. Smr000058521

18. Triprolidine (hydrochloride)

19. Triprolidine Hydrochloride (anh.)

20. Sr-01000075292

21. Einecs 208-985-0

22. Unii-ng7a104r3j

23. Pyridine, 2-((1e)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, Monohydrochloride

24. Prestwick_575

25. Mfcd00039044

26. Opera_id_1214

27. (e)-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine Hydrochloride

28. Trans-2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)pyridine Monohydrochloride

29. Schembl42145

30. Mls001148254

31. Mls002207213

32. Mls002222226

33. Spectrum1500598

34. Chembl1200450

35. Hy-b1808a

36. Dtxsid10872513

37. Hms1568f06

38. Hms1921i07

39. Hms3411o04

40. Hms3675o04

41. Pharmakon1600-01500598

42. Triprolidine Hydrochloride, >=99%

43. Tox21_501130

44. Ccg-40331

45. Nsc757361

46. Triprolidine Monohydrochloride (anh.)

47. Akos015962154

48. Lp01130

49. Triprolidine Monohydrochloride Anhydrous

50. Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, Monohydrochloride, (e)-

51. Ncgc00094397-01

52. Ncgc00094397-02

53. Ncgc00094397-03

54. Ncgc00261815-01

55. Ac-15905

56. As-13971

57. Triprolidine Monohydrochloride (anhydrous)

58. Anhydrous Triprolidine Hydrochloride

59. Triprolidine Hydrochloride [who-dd]

60. Cs-0013855

61. Eu-0101130

62. T 6764

63. 138t790

64. A868718

65. A923663

66. Anhydrous Triprolidine Hydrochloride [mart.]

67. Sr-01000075292-1

68. Sr-01000075292-3

69. Sr-01000075292-7

70. Triprolidine Hydrochloride, Sigma Reference Standard

71. Q27157492

72. (e)-2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)pyridine Monohydrochloride

73. (e)-2-(3-(pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridinehydrochloride

74. (e)-2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]pyridine Hydrochloride

75. 1-[(2e)-3-(4-methylphenyl)-3-(pyridin-2-yl)prop-2-en-1-yl]pyrrolidinium Chloride

76. 2-[(1e)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine Hydrochloride

2.4 Create Date
2006-03-07
3 Chemical and Physical Properties
Molecular Weight 314.9 g/mol
Molecular Formula C19H23ClN2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass314.1549764 g/mol
Monoisotopic Mass314.1549764 g/mol
Topological Polar Surface Area16.1 Ų
Heavy Atom Count22
Formal Charge0
Complexity336
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)


Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)