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    Technical details about Trisalicylate-Choline, learn more about the structure, uses, toxicity, action, side effects and more

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    Trisalicylate-Choline

    APIs // Active Pharmaceutical Ingredients

    PharmaCompass

    Symbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

    Metrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

    2D Structure
    1. Also known as: 64425-90-7, Djj95fjp1h, Choline magnesium salicylate, Cholinemagnesiumtrisalicylate, Trisalicylate-choline, Tegunor
    Molecular Formula
    C26H29MgNO10
    Molecular Weight
    539.8  g/mol
    InChI Key
    FQCQGOZEWWPOKI-UHFFFAOYSA-K
    FDA UNII
    DJJ95FJP1H
    Choline Magnesium Trisalicylate is a nonsteroidal anti-inflammatory drug (NSAID) belonging to the salicylate family. Choline magnesium trisalicylate inhibits inflammation-related prostaglandin synthesis. This agent's analgesic effect is mediated through peripheral and central pathways, resulting in a decrease in pain perception; its antipyretic effect is mediated via the hypothalamic heat regulation center. (NCI04)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    magnesium;2-carboxyphenolate;2-hydroxyethyl(trimethyl)azanium
    2.1.2 InChI
    InChI=1S/3C7H6O3.C5H14NO.Mg/c3*8-6-4-2-1-3-5(6)7(9)10;1-6(2,3)4-5-7;/h3*1-4,8H,(H,9,10);7H,4-5H2,1-3H3;/q;;;+1;+2/p-3
    2.1.3 InChI Key
    FQCQGOZEWWPOKI-UHFFFAOYSA-K
    2.1.4 Canonical SMILES
    C[N+](C)(C)CCO.C1=CC=C(C(=C1)C(=O)O)[O-].C1=CC=C(C(=C1)C(=O)O)[O-].C1=CC=C(C(=C1)C(=O)O)[O-].[Mg+2]
    2.2 Other Identifiers
    2.2.1 UNII
    DJJ95FJP1H
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Tegunor

    2. Tricosal

    3. Trilisate

    2.3.2 Depositor-Supplied Synonyms

    1. 64425-90-7

    2. Djj95fjp1h

    3. Choline Magnesium Salicylate

    4. Cholinemagnesiumtrisalicylate

    5. Trisalicylate-choline

    6. Tegunor

    7. Tricolsal

    8. Unii-djj95fjp1h

    9. Tricosal (tn)

    10. Choline Mixture With Magnesium Salicylate

    11. Dtxsid901344133

    12. Db01401

    13. Nsc 751675

    14. D07694

    15. Choline Magnesium Trisalicylate [who-dd]

    16. Q20817211

    17. ((1,2-ethanediylbis(carbamodithioato))(2-))manganese, Mixt. With ((1,2-ethanediylbis(carbamodithioato))(2-))zinc & 2(or 4)-isooctyl-4,6(or 2,6)-dinitrophenyl 2-buten Oate

    18. Ethanaminium, 2-hydroxy-n,n,n-trimethyl-, 2-hydroxybenzoate (1:1), Mixt. With (t-4)-bis(2-(hydroxy-.kappa.o)benzoato-.kappa.o)magnesium

    19. Ethanaminium, 2-hydroxy-n,n,n-trimethyl-, Salt With 2-hydroxybenzoic Acid (1:1), Mixt. With 2-hydroxybenzoic Acid Magnesium Salt (2:1)

    2.4 Create Date
    2011-12-26
    3 Chemical and Physical Properties
    Molecular Weight 539.8 g/mol
    Molecular Formula C26H29MgNO10
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count10
    Rotatable Bond Count5
    Exact Mass539.1641878 g/mol
    Monoisotopic Mass539.1641878 g/mol
    Topological Polar Surface Area201 Ų
    Heavy Atom Count38
    Formal Charge0
    Complexity179
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count5
    4 Drug and Medication Information
    4.1 Drug Indication

    Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Trisalicylate-choline is a non-steroidal anti-inflammatory drug (NSAID) that contains a combination of choline salicylate and magnesium salicylate. Does not affect platelet aggregation.

    5.2 MeSH Pharmacological Classification

    Analgesics

    Compounds capable of relieving pain without the loss of CONSCIOUSNESS. (See all compounds classified as Analgesics.)

    Anti-Inflammatory Agents, Non-Steroidal

    Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

    5.3 Absorption, Distribution and Excretion

    Route of Elimination

    renal

    5.4 Mechanism of Action

    Inhibits prostaglandin synthesis; acts on the hypothalamus heat-regulating center to reduce fever; blocks the generation of pain impulses

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