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    Technical details about Tropisetron hydrochloride, learn more about the structure, uses, toxicity, action, side effects and more

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    Tropisetron hydrochloride

    APIs // Active Pharmaceutical Ingredients

    DOSSIERs // Finished Dosage Forms

    GLOBAL SALES INFORMATION

    REF. STANDARDS & IMPURITIES

    PharmaCompass

    Symbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

    Metrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

    2D Structure
    1. Also known as: Tropisetron hydrochloride, 105826-92-4, 3-tropanyl-indole-3-carboxylate hydrochloride, Sdz-ics-930 (free base), Sdz-ics-930, Ics 205-930
    Molecular Formula
    C17H21ClN2O2
    Molecular Weight
    320.8  g/mol
    InChI Key
    XIEGSJAEZIGKSA-UHFFFAOYSA-N
    An indole derivative and 5-HT3 RECEPTOR antagonist that is used for the prevention of nausea and vomiting.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 1H-indole-3-carboxylate;hydrochloride
    2.1.2 InChI
    InChI=1S/C17H20N2O2.ClH/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16;/h2-5,10-13,18H,6-9H2,1H3;1H
    2.1.3 InChI Key
    XIEGSJAEZIGKSA-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43.Cl
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. (3 Alpha-tropanyl)-1h-indole-3-carboxylic Acid Ester

    2. Ics 205 930

    3. Ics 205-930

    4. Ics 205930

    5. Ics-205-930

    6. Ics-205930

    7. Indole 3 Carboxylic Acid Tropine Ester

    8. Indole-3-carboxylic Acid Tropine Ester

    9. Tropisetron

    10. Tropisetron Hydrochloride

    2.2.2 Depositor-Supplied Synonyms

    1. Tropisetron Hydrochloride

    2. 105826-92-4

    3. 3-tropanyl-indole-3-carboxylate Hydrochloride

    4. Sdz-ics-930 (free Base)

    5. Sdz-ics-930

    6. Ics 205-930

    7. 3-tropanylindole-3-carboxylate Hydrochloride

    8. Mls001148140

    9. Chembl554182

    10. Schembl6273985

    11. (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 1h-indole-3-carboxylate Hydrochloride

    12. Pharmakon1600-01502344

    13. Bcp07756

    14. Tox21_501253

    15. Ac-789

    16. Nsc759842

    17. Akos015951162

    18. Ccg-213827

    19. Ics-205,930; Navoban; Tropisetron

    20. Lp01253

    21. (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 1h-indole-3-carboxylate Hydrochloride

    22. Ncgc00094493-01

    23. Ncgc00261938-01

    24. Smr000653456

    25. Db-040658

    26. Eu-0101253

    27. Ft-0630963

    28. T-104

    29. T2743

    30. (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 1h-indole-3-carboxylic Acid Ester Monohydrochloride

    31. A801326

    32. Sr-01000075588

    33. J-500370

    34. Sr-01000075588-1

    35. Tropisetron Monohydrochloride, Solid, >=98% (hplc)

    36. Tropisetron Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    37. (1r,5s)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 1h-indole-3-carboxylate Hydrochloride

    38. 1h-indole-3-carboxylic Acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) Ester Hydrochloride

    39. 8-methyl-8-azabicyclo[3.2.1]octan-3-yl 1h-indole-3-carboxylate Hydrochloride

    2.3 Create Date
    2006-10-25
    3 Chemical and Physical Properties
    Molecular Weight 320.8 g/mol
    Molecular Formula C17H21ClN2O2
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count3
    Exact Mass320.1291556 g/mol
    Monoisotopic Mass320.1291556 g/mol
    Topological Polar Surface Area45.3 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity400
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antiemetics

    Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

    Serotonin 5-HT3 Receptor Antagonists

    Drugs that bind to but do not activate SEROTONIN 5-HT3 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT3 RECEPTOR AGONISTS. (See all compounds classified as Serotonin 5-HT3 Receptor Antagonists.)

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