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2D Structure
Also known as: 10405-02-4, Sanctura, Spasmex, Relaspium, Spasmo-lyt, Uraplex
Molecular Formula
C25H30ClNO3
Molecular Weight
428.0  g/mol
InChI Key
RVCSYOQWLPPAOA-DHWZJIOFSA-M
FDA UNII
1E6682427E

1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(1R,5S)-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl] 2-hydroxy-2,2-diphenylacetate;chloride
2.1.2 InChI
InChI=1S/C25H30NO3.ClH/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26;/h1-6,9-12,21-23,28H,7-8,13-18H2;1H/q+1;/p-1/t21-,22+,23?;
2.1.3 InChI Key
RVCSYOQWLPPAOA-DHWZJIOFSA-M
2.1.4 Canonical SMILES
C1CC[N+]2(C1)C3CCC2CC(C3)OC(=O)C(C4=CC=CC=C4)(C5=CC=CC=C5)O.[Cl-]
2.1.5 Isomeric SMILES
C1CC[N+]2(C1)[C@@H]3CC[C@H]2CC(C3)OC(=O)C(C4=CC=CC=C4)(C5=CC=CC=C5)O.[Cl-]
2.2 Other Identifiers
2.2.1 UNII
1E6682427E
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Azoniaspiro Compound Xvii

2. Azoniaspiro(3 Alpha-benziloyloxynortropane-8,1'- Pyrrolidine) Chloride

3. Ceris

4. Spasmex

5. Spasmo-lyt

6. Spasmo-rhoival Tc

7. Spasmo-urgenin

8. Spasmo-urgenin Tc

9. Spasmolyt

10. Trospi

11. Uraplex

12. Uraton

2.3.2 Depositor-Supplied Synonyms

1. 10405-02-4

2. Sanctura

3. Spasmex

4. Relaspium

5. Spasmo-lyt

6. Uraplex

7. Sanctura Xr

8. Regurin

9. Santura

10. Trospium Cl

11. Trospii Chloridum

12. Cloruro De Trospio

13. Spasmo 3

14. Chlorure De Trospium

15. Trospium (chloride)

16. Ip631

17. Spasmoplex

18. Ip-631

19. Trospium Chloride (sanctura)

20. 1e6682427e

21. Dsstox_cid_3724

22. Dsstox_rid_77166

23. Dsstox_gsid_23724

24. Keptan

25. Azoniaspiro Compound Xvii

26. Flotros

27. As Xvii

28. Rel-(1r,3r,5s)-3-(2-hydroxy-2,2-diphenylacetoxy)spiro[bicyclo[3.2.1]octane-8,1'-pyrrolidin]-1'-ium Chloride

29. Cas-10405-02-4

30. Ncgc00167438-01

31. Ncgc00167438-02

32. Trospiumchlorid

33. Spasmed

34. Trofame

35. Trospikan

36. Trosec

37. Regurin Xl

38. Trospii Chloridum [inn-latin]

39. Cloruro De Trospio [inn-spanish]

40. Unii-1e6682427e

41. Chlorure De Trospium [inn-french]

42. [(1s,5r)-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl] 2-hydroxy-2,2-diphenylacetate;chloride

43. Einecs 233-875-4

44. Trospium Chloride [usan:usp:inn:ban:jan]

45. Schembl25785

46. Trospium Chloride [mi]

47. Trospium Chloride [inn]

48. Trospium Chloride [jan]

49. Chembl3084748

50. Schembl13836646

51. Trospium Chloride [usan]

52. Chebi:32270

53. Trospium Chloride [mart.]

54. Hms3656c16

55. Hms3884h08

56. Trospium Chloride [usp-rs]

57. Trospium Chloride [who-dd]

58. Bcp23426

59. Hy-b0461

60. Tox21_112442

61. 8-alpha-benziloyloxy-6,10-ethano-5-azoniaspiro(4.5)decane Chloride

62. Azoniaspiro(3-alpha-benziloyloxy-nortropan-8,1'-pyrrolidine)-chloride

63. Bdbm50540489

64. Mfcd00865254

65. S2549

66. Akos015833209

67. Tox21_112442_1

68. Ac-4235

69. Ccg-268976

70. Trospium Chloride [orange Book]

71. Trospium Chloride [ep Monograph]

72. Trospium Chloride [usp Monograph]

73. Bcp0726000291

74. Sw219146-1

75. T3305

76. I11574

77. A800884

78. W-108827

79. Q27252312

80. 3alpha-hydroxyspiro(1alphah,5alphah-nortropane-8,1'-pyrrolidinium) Chloride Benzilate

81. (1s,3r,5r)-3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-8lambda(5)-azaspiro[bicyclo[3.2.1]octane-8,1'-pyrrolidin]-8-ylium Chloride

82. [(1s,5r)-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl] 2-oxidanyl-2,2-diphenyl-ethanoate Chloride

83. 2-hydroxy-2,2-diphenylacetic Acid [(1s,5r)-3-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]yl] Ester Chloride

84. 3.alpha.-hydroxy-spiro(1.alpha.h,5.alpha.h-nortropane-8,1'-pyrrolidinium) Chloride Benzilate

85. Rel-(1r,3r,5s)-3-(2-hydroxy-2,2-diphenylacetoxy)spiro[bicyclo[3.2.1]octane-8,1'-pyrrolidin]-1'-iumchloride

86. Spiro (8-azoniabicyclo(3.2.1)octane-8,1'-pyrrolidinium), 3-((hydroxydiphenylacetyl)oxy)-, Chloride, (1alpha, 3beta, 5alpha)

87. Spiro(1-alpha-h,5-alpha-h-nortropane-8,1'-pyrrolidinium), 3-alpha-hydroxy-, Chloride, Benzilate

88. Spiro(8-azoniabicyclo(3.2.1)octane-8,1'-pyrrolidinium), 3-((hydroxydiphenylacetyl)oxy)-, Chloride, (1.alpha., 3.beta., 5.alpha.)

89. Spiro(8-azoniabicyclo(3.2.1)octane-8,1'-pyrrolidinium, 3-((hydroxydiphenylacetyl)oxy)-, Chloride, (1alpha,3beta,5alpha)-

2.4 Create Date
2005-11-20
3 Chemical and Physical Properties
Molecular Weight 428.0 g/mol
Molecular Formula C25H30ClNO3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass427.1914215 g/mol
Monoisotopic Mass427.1914215 g/mol
Topological Polar Surface Area46.5 Ų
Heavy Atom Count30
Formal Charge0
Complexity553
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 6  
Drug NameSanctura
Drug LabelSANCTURA XR is an extended-release formulation of trospium chloride, a quaternary ammonium compound with the chemical name of Spiro [8-azoniabicyclo[3.2.1]octane-8,1'-pyrrolidinium], 3-[(hydroxydiphenylacetyl)oxy]-, chloride, (1, 3, 5). The e...
Active IngredientTrospium chloride
Dosage FormTablet
RouteOral
Strength20mg
Market StatusPrescription
CompanyAllergan

2 of 6  
Drug NameSanctura xr
Drug LabelSANCTURA XR is an extended-release formulation of trospium chloride, a quaternary ammonium compound with the chemical name of Spiro [8-azoniabicyclo[3.2.1]octane-8,1'-pyrrolidinium], 3-[(hydroxydiphenylacetyl)oxy]-, chloride, (1, 3, 5). The e...
Active IngredientTrospium chloride
Dosage FormCapsule, extended release
RouteOral
Strength60mg
Market StatusPrescription
CompanyAllergan

3 of 6  
Drug NameTrospium chloride
PubMed HealthTrospium (By mouth)
Drug ClassesUrinary Antispasmodic
Drug LabelTrospium Chloride Extended-Release Capsules are an extended-release formulation of trospium chloride, a quaternary ammonium compound with the chemical name of Spiro [8-azoniabicyclo[3.2.1]octane-8,1'-pyrrolidinium], 3-[(hydroxydiphenylacetyl)oxy]-, c
Active IngredientTrospium chloride
Dosage FormTablet; Capsule, extended release
RouteOral
Strength60mg; 20mg
Market StatusPrescription
CompanyActavis Labs Fl; Apotex; Glenmark Generics; Paddock

4 of 6  
Drug NameSanctura
Drug LabelSANCTURA XR is an extended-release formulation of trospium chloride, a quaternary ammonium compound with the chemical name of Spiro [8-azoniabicyclo[3.2.1]octane-8,1'-pyrrolidinium], 3-[(hydroxydiphenylacetyl)oxy]-, chloride, (1, 3, 5). The e...
Active IngredientTrospium chloride
Dosage FormTablet
RouteOral
Strength20mg
Market StatusPrescription
CompanyAllergan

5 of 6  
Drug NameSanctura xr
Drug LabelSANCTURA XR is an extended-release formulation of trospium chloride, a quaternary ammonium compound with the chemical name of Spiro [8-azoniabicyclo[3.2.1]octane-8,1'-pyrrolidinium], 3-[(hydroxydiphenylacetyl)oxy]-, chloride, (1, 3, 5). The e...
Active IngredientTrospium chloride
Dosage FormCapsule, extended release
RouteOral
Strength60mg
Market StatusPrescription
CompanyAllergan

6 of 6  
Drug NameTrospium chloride
PubMed HealthTrospium (By mouth)
Drug ClassesUrinary Antispasmodic
Drug LabelTrospium Chloride Extended-Release Capsules are an extended-release formulation of trospium chloride, a quaternary ammonium compound with the chemical name of Spiro [8-azoniabicyclo[3.2.1]octane-8,1'-pyrrolidinium], 3-[(hydroxydiphenylacetyl)oxy]-, c
Active IngredientTrospium chloride
Dosage FormTablet; Capsule, extended release
RouteOral
Strength60mg; 20mg
Market StatusPrescription
CompanyActavis Labs Fl; Apotex; Glenmark Generics; Paddock

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Muscarinic Antagonists

Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)


Urological Agents

Drugs used in the treatment of urological conditions and diseases such as URINARY INCONTINENCE and URINARY TRACT INFECTIONS. (See all compounds classified as Urological Agents.)


Parasympatholytics

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Cholinergic Muscarinic Antagonists [MoA]; Cholinergic Muscarinic Antagonist [EPC]