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    Technical details about Tyloxapol API, learn more about the structure, uses, toxicity, action, side effects and more

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    Tyloxapol API

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    DOSSIERs // Finished Dosage Forms

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    REF. STANDARDS & IMPURITIES

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    2D Structure
    1. Also known as: Tyloxapol, 25301-02-4, Tyloxypal, Triton wr-1339, Superinone, Alevaire
    Molecular Formula
    C17H28O3
    Molecular Weight
    280.4  g/mol
    InChI Key
    MDYZKJNTKZIUSK-UHFFFAOYSA-N
    Tyloxapol is a non-ionic detergent often used as a surfactant.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    formaldehyde;oxirane;4-(2,4,4-trimethylpentan-2-yl)phenol
    2.1.2 InChI
    InChI=1S/C14H22O.C2H4O.CH2O/c1-13(2,3)10-14(4,5)11-6-8-12(15)9-7-11;1-2-3-1;1-2/h6-9,15H,10H2,1-5H3;1-2H2;1H2
    2.1.3 InChI Key
    MDYZKJNTKZIUSK-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C)(C)CC(C)(C)C1=CC=C(C=C1)O.C=O.C1CO1
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Alevaire

    2. Enuclene

    3. Formaldehyde, Polymer With Oxirane And 4-(1,1,3,3-tetramethylbutyl)phenol

    4. Oxyethylated Tertiary Octylphenol Formaldehyde Polymer

    5. P-isooctylpolyoxyethylenephenol Formaldehyde Polymer

    6. Polyhydroxyethyl-tert-octylphenolformaldehyde

    7. Superinone

    8. Supervent

    9. Translight

    10. Triton A 20

    11. Triton Wr 1339

    12. Triton Wr-1339

    13. Tyloxapol

    14. Tyroxapol

    15. Wr-1339

    2.2.2 Depositor-Supplied Synonyms

    1. Tyloxapol

    2. 25301-02-4

    3. Tyloxypal

    4. Triton Wr-1339

    5. Superinone

    6. Alevaire

    7. Nsc90255

    8. Formaldehyde;oxirane;4-(2,4,4-trimethylpentan-2-yl)phenol

    9. Triton A-20

    10. Formaldehyde, Polymer With Oxirane And4-(1,1,3,3-tetramethylbutyl)phenolother Ca Index Names:oxirane, Polymer With Formaldehyde And4-(1,1,3,3-tetramethylbutyl)phenolphenol, 4-(1,1,3,3-tetramethylbutyl)-, Polymer With Formaldehyde Andoxirane

    11. Superiuone

    12. Component Of Alevaire

    13. Formaldehyde; Oxirane; 4-(1,1,3,3-tetramethylbutyl)phenol

    14. Schembl181284

    15. Dtxsid30179950

    16. Chebi:141517

    17. Nsc-90255

    18. Akos026749862

    19. Formaldehyde,1,3,3-tetra Methylbutyl)phenol

    20. Ab01563398_01

    21. Q7860340

    22. Ethoxylated P-tert-octylphenol Formaldehyde Polymer

    23. Wln: /qr Dx1&1&1x1&1&1/ &/*o2*/ &/*o1*/

    24. Phenol,1,3,3-tetramethylbutyl)-, Polymer With Ethylene Oxide And Formaldehyde

    2.3 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 280.4 g/mol
    Molecular Formula C17H28O3
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count3
    Exact Mass280.20384475 g/mol
    Monoisotopic Mass280.20384475 g/mol
    Topological Polar Surface Area49.8 Ų
    Heavy Atom Count20
    Formal Charge0
    Complexity204
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Indication

    Tyloxapol is an inhaled surfactant that assists in removing and liquefying and removing bronchopulmonary secretions with mucus and pus. Tyloxapol is administered either through nebulized solution or a stream of oxygen. Also investigated for use/treatment in cystic fibrosis and pediatric indications.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    It is used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions. Tyloxapol also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins.

    5.2 MeSH Pharmacological Classification

    Surface-Active Agents

    Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics. (See all compounds classified as Surface-Active Agents.)

    Detergents

    Purifying or cleansing agents, usually salts of long-chain aliphatic bases or acids, that exert cleansing (oil-dissolving) and antimicrobial effects through a surface action that depends on possessing both hydrophilic and hydrophobic properties. (See all compounds classified as Detergents.)

    5.3 ATC Code

    R - Respiratory system

    R05 - Cough and cold preparations

    R05C - Expectorants, excl. combinations with cough suppressants

    R05CA - Expectorants

    R05CA01 - Tyloxapol

    5.4 Mechanism of Action

    Tyloxapol, when injected IP, blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins. It has also been shown to be inhibitor of lipoprotein lipase, thus preventing triglyceride uptake.

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