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    Technical details about UNII-MC34P30298, learn more about the structure, uses, toxicity, action, side effects and more

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    UNII-MC34P30298

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    2D Structure
    1. Also known as: Imipramine embonate, 10075-24-8, Imipramine (pamoate), Mc34p30298, 4,4'-methylenebis(3-hydroxy-2-naphthoic) acid, compound with 10,11-dihydro-n,n-dimethyl-5h-dibenz(b,f)azepine-5-propylamine (1:2), 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid;3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-n,n-dimethylpropan-1-amine
    Molecular Formula
    C61H64N4O6
    Molecular Weight
    949.2  g/mol
    InChI Key
    BPQZYOJIXDMZSX-UHFFFAOYSA-N
    FDA UNII
    MC34P30298
    The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid;3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
    2.1.2 InChI
    InChI=1S/C23H16O6.2C19H24N2/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;2*1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h1-10,24-25H,11H2,(H,26,27)(H,28,29);2*3-6,8-11H,7,12-15H2,1-2H3
    2.1.3 InChI Key
    BPQZYOJIXDMZSX-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31.CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31.C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    MC34P30298
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 4,4'-methylenebis(3-hydroxy-2-naphthoic Acid)-3-(10,11-dihydro-5h-dibenzo(b,f)azepin-5-yl)-n,n-dimethyl-1-propanamine (1:2)

    2. Imidobenzyle

    3. Imipramine

    4. Imipramine Hydrochloride

    5. Imipramine Monohydrochloride

    6. Imizin

    7. Janimine

    8. Melipramine

    9. Norchlorimipramine

    10. Pryleugan

    11. Tofranil

    2.3.2 Depositor-Supplied Synonyms

    1. Imipramine Embonate

    2. 10075-24-8

    3. Imipramine (pamoate)

    4. Mc34p30298

    5. 4,4'-methylenebis(3-hydroxy-2-naphthoic) Acid, Compound With 10,11-dihydro-n,n-dimethyl-5h-dibenz(b,f)azepine-5-propylamine (1:2)

    6. 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic Acid;3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-n,n-dimethylpropan-1-amine

    7. Einecs 233-206-6

    8. Unii-mc34p30298

    9. Tofranil-pm (tn)

    10. Imipramine Pamoate (usp)

    11. 5h-dibenz(b,f)azepine, 5-(3-(dimethylamino)propyl)-10,11-dihydro-, Pamoate

    12. Imipramine Pamoate [mi]

    13. Chembl3989845

    14. Schembl21834068

    15. Dtxsid80143484

    16. Imipramine Pamoate [vandf]

    17. Imipramine Embonate [mart.]

    18. Imipramine Pamoate [usp-rs]

    19. Imipramine Embonate [who-dd]

    20. Imipramine Pamoate [orange Book]

    21. 2-naphthalenecarboxylic Acid, 4,4'-methylenebis(3-hydroxy-, Compd. With 10,11-dihydro-n,n-dimethyl-5h-dibenz(b,f)azepine-5-propanamine (1:2)

    22. Imipramine Pamoate [usp Monograph]

    23. Hy-107956

    24. Cs-0030995

    25. D08071

    26. Q27283837

    27. 2-naphthalenecarboxylic Acid, 4,4'-methylenebis(3-hydroxy-, Compd. With 10,11-dihydro-n,n-2-naphthalenecarboxylic Acid, 4,4'-methylenebis(3-hydroxy-, Compd. With 10,11-dihydro-n,n-dimethyl-5h-dibenz(b,f)azepine-5-propanamine (1:2)

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 949.2 g/mol
    Molecular Formula C61H64N4O6
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count10
    Rotatable Bond Count12
    Exact Mass948.48258577 g/mol
    Monoisotopic Mass948.48258577 g/mol
    Topological Polar Surface Area128 Ų
    Heavy Atom Count71
    Formal Charge0
    Complexity859
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Adrenergic Uptake Inhibitors

    Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (See all compounds classified as Adrenergic Uptake Inhibitors.)

    Antidepressive Agents, Tricyclic

    Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system. (See all compounds classified as Antidepressive Agents, Tricyclic.)

    4.2 FDA Pharmacological Classification
    4.2.1 Pharmacological Classes
    Tricyclic Antidepressant [EPC]
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