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    Technical details about Veliparib, learn more about the structure, uses, toxicity, action, side effects and more

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    Veliparib

    PharmaCompass

    Symbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

    Metrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

    2D Structure
    1. Also known as: 912444-00-9, Abt-888, Abt 888, Abt-888 (veliparib), Veliparib free base, Abt888
    Molecular Formula
    C13H16N4O
    Molecular Weight
    244.29  g/mol
    InChI Key
    JNAHVYVRKWKWKQ-CYBMUJFWSA-N
    FDA UNII
    01O4K0631N
    Veliparib is a poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with chemosensitizing and antitumor activities. With no antiproliferative effects as a single agent at therapeutic concentrations, ABT-888 inhibits PARPs, thereby inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents. PARP nuclear enzymes are activated by DNA single or double strand breaks, resulting in the poly(ADP-ribosyl)ation of other nuclear DNA binding proteins involved in DNA repair; poly(ADP-ribosyl)ation contributes to efficient DNA repair and to survival of proliferating cells exposed to mild genotoxic stresses as induced by as oxidants, alkylating agents or ionizing radiation.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide
    2.1.2 InChI
    InChI=1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1
    2.1.3 InChI Key
    JNAHVYVRKWKWKQ-CYBMUJFWSA-N
    2.1.4 Canonical SMILES
    CC1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N
    2.1.5 Isomeric SMILES
    C[C@@]1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N
    2.2 Other Identifiers
    2.2.1 UNII
    01O4K0631N
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-((r)-2-methylpyrrolidin-2-yl)-1h-benzimidazole-4-carboxamide

    2. 2-(2-methylpyrrolidin-2-yl)-1h-benzimidazole-4-carboxamide

    3. Abt 888

    4. Abt-888

    5. Abt888

    2.3.2 Depositor-Supplied Synonyms

    1. 912444-00-9

    2. Abt-888

    3. Abt 888

    4. Abt-888 (veliparib)

    5. Veliparib Free Base

    6. Abt888

    7. (r)-2-(2-methylpyrrolidin-2-yl)-1h-benzo[d]imidazole-4-carboxamide

    8. 2-[(2r)-2-methylpyrrolidin-2-yl]-1h-benzimidazole-4-carboxamide

    9. 2-[(2r)-2-methyl-2-pyrrolidinyl]-1h-benzimidazole-7-carboxamide

    10. Chebi:62880

    11. 2-[(r)-2-methylpyrrolidin-2-yl]-1h-benzimidazole-4-carboxamide

    12. Parp-1 Inhibitor Abt-888

    13. 912444-00-9 (free Base)

    14. 01o4k0631n

    15. 2-[(2r)-2-methylpyrrolidin-2-yl]-1h-benimidazole-4-

    16. (2r)-2-(7-carbamoyl-1h-benzimidazol-2-yl)-2-methylpyrrolidinium

    17. 2-((r)-2-methylpyrrolidin-2-yl)-1h-benzimidazole-4-carboxamide

    18. Veliparib (abt-888)

    19. (r)-2-(2-methylpyrrolidin-2-yl)-1h-benimidazole-4-carboxamide (veliparib)

    20. 2-((2r)-2-methyl-2-pyrrolidinyl)-1h-benzimidazole-7-carboxamide

    21. 2-((2r)-2-methylpyrrolidin-2-yl)-1h-benzimidazole-4-carboxamide

    22. Nsc-737664

    23. Veliparib [usan:inn]

    24. Mfcd16661059

    25. Unii-01o4k0631n

    26. 78p

    27. Veliparib [inn]

    28. Veliparib [jan]

    29. Veliparib [usan]

    30. Abt888 (free Base)

    31. (r)-2-(2-methylpyrrolidin-2-yl)-1h-benzo[d]imidazole-7-carboxamide

    32. Veliparib [who-dd]

    33. Benzimidazole Carboxamide, 3a

    34. Mls006010184

    35. Veliparib (jan/usan/inn)

    36. Schembl422318

    37. Chembl506871

    38. Gtpl7417

    39. Bdbm27135

    40. Abt-695

    41. Dtxsid90238456

    42. Ex-a001

    43. Bdbm209932

    44. Veliparib (abt-888 Hydrochloride)

    45. 2-[(2r)-2-methylpyrrolidin-2-yl]-1h-1,3-benzodiazole-4-carboxamide

    46. Nsc737664

    47. Nsc752840

    48. S1004

    49. Zinc84610155

    50. Akos015951440

    51. Akos017343746

    52. Ccg-264771

    53. Cs-0076

    54. Db07232

    55. Ex-7209

    56. Nsc 737664

    57. Nsc-752840

    58. Sb16480

    59. Ncgc00250404-01

    60. Ncgc00250404-15

    61. Ac-23330

    62. As-19397

    63. Hy-10129

    64. Smr004701290

    65. Abt-888 (veliparib, Nsc 737664)

    66. A24888

    67. D09692

    68. A 861695

    69. A-861695

    70. J-505211

    71. Q7919041

    72. Brd-k87142802-001-02-7

    73. 1h-benzimidazole-4-carboxamide, 2-((2r)-2-methyl-2-pyrrolidinyl)-

    74. 2-[(2r)-2-methylpyrrolidin-2-yl]-1h-benimidazole-4-carboxamide

    75. 2-[(2r)-2-methylpyrrolidin-2-yl]-1h-benzimidazole-7-carboxamide

    76. 2-[(r)-2-methylpyrrolidin-2-yl]-1h-benzimidazole-4-carboxamide;

    77. 1h-benzimidazole-7-carboxamide, 2-((2r)-2-methyl-2-pyrrolidinyl)-

    2.4 Create Date
    2006-12-11
    3 Chemical and Physical Properties
    Molecular Weight 244.29 g/mol
    Molecular Formula C13H16N4O
    XLogP30.5
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count2
    Exact Mass244.13241115 g/mol
    Monoisotopic Mass244.13241115 g/mol
    Topological Polar Surface Area83.8 Ų
    Heavy Atom Count18
    Formal Charge0
    Complexity348
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Treatment of fallopian tube cancer , Treatment of ovarian cancer , Treatment of peritoneal carcinoma

    Treatment of lung carcinoma (small cell and non-small cell carcinoma)

    Treatment of breast cancer

    Treatment of high-grade glioma

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Poly(ADP-ribose) Polymerase Inhibitors

    Chemicals and drugs that inhibit the action of POLY(ADP-RIBOSE)POLYMERASES. (See all compounds classified as Poly(ADP-ribose) Polymerase Inhibitors.)

    5.2 ATC Code

    L - Antineoplastic and immunomodulating agents

    L01 - Antineoplastic agents

    L01X - Other antineoplastic agents

    L01XK - Poly (adp-ribose) polymerase (parp) inhibitors

    L01XK05 - Veliparib

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