loader
Please Wait
Applying Filters...
menu
    • menu

    Technical details about Vosilasarm, learn more about the structure, uses, toxicity, action, side effects and more

    Client Email Product
    ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

    Virtual Booth

    Contact Supplier

    FAMAR CDMO- From early development to commercial manufacturing.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-09-09

    Virtual Booth

    Contact Supplier

    Seqens is an integrated global leader in pharmaceutical solutions & specialty ingredients & provides custom-made solutions.

    Virtual Booth

    Contact Supplier

    Veranova: A CDMO that manages complexity with confidence.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-09-09

    Virtual Booth

    Contact Supplier

    Menu

    Vosilasarm

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

    PRICE INFORMATION

    PharmaCompass
    $ API Ref.Price (USD/KG) : 12,232Xls

    Filters

    clear-filterReset all filters
    2D Structure
    Also known as: Rad140, 1182367-47-0, Vosilasarm, Rad-140, 4o87q44knc, 2-chloro-4-[[(1r,2s)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile
    Molecular Formula
    C20H16ClN5O2
    Molecular Weight
    393.8  g/mol
    InChI Key
    XMBUPPIEVAFYHO-KPZWWZAWSA-N
    FDA UNII
    4O87Q44KNC
    Vosilasarm is an orally bioavailable, non-steroidal selective androgen receptor modulator (SARM), with potential tissue-selective androgenic/anti-androgenic activities. Upon oral administration, vosilasarm acts as an agonist in select tissues, such as skeletal muscle and bone, where it binds to and activates androgen receptors (ARs). In the prostate and breasts, RAD140 acts as an antagonist and blocks AR activation and AR-mediated cellular proliferation. Therefore, this agent may improve bone formation and muscle mass and strength, and may inhibit both the growth of the prostate in males and AR-dependent breast cancer cell proliferation. Compared to anabolic agents, SARMs have reduced androgenic properties.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile
    2.1.2 InChI
    InChI=1S/C20H16ClN5O2/c1-11-16(8-7-15(10-23)17(11)21)24-18(12(2)27)20-26-25-19(28-20)14-5-3-13(9-22)4-6-14/h3-8,12,18,24,27H,1-2H3/t12-,18+/m0/s1
    2.1.3 InChI Key
    XMBUPPIEVAFYHO-KPZWWZAWSA-N
    2.1.4 Canonical SMILES
    CC1=C(C=CC(=C1Cl)C#N)NC(C2=NN=C(O2)C3=CC=C(C=C3)C#N)C(C)O
    2.1.5 Isomeric SMILES
    CC1=C(C=CC(=C1Cl)C#N)N[C@@H](C2=NN=C(O2)C3=CC=C(C=C3)C#N)[C@H](C)O
    2.2 Other Identifiers
    2.2.1 UNII
    4O87Q44KNC
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-chloro-4-(((1r,2s)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropyl)amino)-3-methylbenzonitrile

    2. Rad 140

    3. Rad-140

    4. Rad140

    2.3.2 Depositor-Supplied Synonyms

    1. Rad140

    2. 1182367-47-0

    3. Vosilasarm

    4. Rad-140

    5. 4o87q44knc

    6. 2-chloro-4-[[(1r,2s)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile

    7. Chembl1672635

    8. 2-chloro-4-(((1r,2s)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropyl)amino)-3-methylbenzonitrile

    9. 2-chloro-4-((1r,2s)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropylamino)-3-methylbenzonitrile

    10. Benzonitrile, 2-chloro-4-(((1r,2s)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropyl)amino)-3-methyl-

    11. Vosilasarm [inn]

    12. Unii-4o87q44knc

    13. Vosilasarm [who-dd]

    14. Testolone [nflis-drug]

    15. Schembl1363683

    16. Ex-a725

    17. Rad140,

    18. Dtxsid201032907

    19. Bcp16214

    20. Bdbm50336997

    21. Mfcd20527233

    22. S5275

    23. Zinc66097792

    24. Ccg-268578

    25. Cs-4670

    26. Db13939

    27. Ncgc00485476-01

    28. 2-chloro-4-({1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl}amino)-3-methylbenzonitrile

    29. Ac-30220

    30. Hy-14383

    31. J-690050

    32. Q25099854

    33. 2-chloro-4-[[(1r,2s)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazole-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile

    2.4 Create Date
    2009-09-21
    3 Chemical and Physical Properties
    Molecular Weight 393.8 g/mol
    Molecular Formula C20H16ClN5O2
    XLogP33.1
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count5
    Exact Mass393.0992525 g/mol
    Monoisotopic Mass393.0992525 g/mol
    Topological Polar Surface Area119 Ų
    Heavy Atom Count28
    Formal Charge0
    Complexity623
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1