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    Xenon Radioisotopes

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    PharmaCompass
    Xls

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    2D Structure
    Also known as: Xenon-133, Xenon xe 133, Xenon (133xe), Xenon, xe-133, 14932-42-4, Xenon (133 xe)
    Molecular Formula
    Xe
    Molecular Weight
    132.90591  g/mol
    InChI Key
    FHNFHKCVQCLJFQ-NJFSPNSNSA-N
    FDA UNII
    X3P9A5HNYF
    Xenon Xe-133 is a radioisotope of xenon, an element with 54 protons, having gamma emissions and a physical half-life of 5.27 days. Xenon-133 is used in the study of pulmonary function and organ blood flow.
    Xenon xe-133 is an Inhalation Diagnostic Agent. The mechanism of action of xenon xe-133 is as a Radiopharmaceutical Activity.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    xenon-133
    2.1.2 InChI
    InChI=1S/Xe/i1+2
    2.1.3 InChI Key
    FHNFHKCVQCLJFQ-NJFSPNSNSA-N
    2.1.4 Canonical SMILES
    [Xe]
    2.1.5 Isomeric SMILES
    [133Xe]
    2.2 Other Identifiers
    2.2.1 UNII
    X3P9A5HNYF
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 133xe Radioisotope

    2. Xe-133 Radioisotope

    3. Xenon-133

    2.3.2 Depositor-Supplied Synonyms

    1. Xenon-133

    2. Xenon Xe 133

    3. Xenon (133xe)

    4. Xenon, Xe-133

    5. 14932-42-4

    6. Xenon (133 Xe)

    7. Xenon (133xe) Gas

    8. Xenon 133

    9. X3p9a5hnyf

    10. Xenon (133xe) [inn]

    11. Xeneisol

    12. Xenon Xe 133-v.s.s.

    13. Xenonum (133 Xe)

    14. Unii-x3p9a5hnyf

    15. Xenon Xe 133 [usan]

    16. Xenon, Isotope Of Mass 133

    17. Mpi Xenon Xe 133 Gas Vials

    18. Mpi Xenon Xe 133 Gas Ampule

    19. Xe-133

    20. Xenon Xe 133 [usan:usp]

    21. Xenon ((sup 133)xe) Injection

    22. Xenon Radioisotopes

    23. Xenonum (133 Xe) [inn-latin]

    24. 133xe Radioisotope

    25. Xe-133 Radioisotope

    26. Xenon,xe-133

    27. Xenon (133xe) Injection

    28. Xenon Xe 133 (tn)

    29. Xenon Xe 133 Gas Vials

    30. Xenon ((sup 133)xe)

    31. Xenon Xe 133 Gas Ampule

    32. Chembl1200685

    33. Xenon Xe 133 [mi]

    34. Xenon-133 [mart.]

    35. Dtxsid70933614

    36. Xenon,xe-133 [vandf]

    37. 133xe

    38. Xenon (133xe) [jan]

    39. Xenon Xe 133 (jan/usp/inn)

    40. Xenon (133 Xe) [who-dd]

    41. Xenon Xe-133 [orange Book]

    42. Db09315

    43. Xenon Xe 133 [usp Monograph]

    44. D06339

    45. Q2451397

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 132.90591 g/mol
    Molecular Formula Xe
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count0
    Rotatable Bond Count0
    Exact Mass132.90591 g/mol
    Monoisotopic Mass132.90591 g/mol
    Topological Polar Surface Area0 Ų
    Heavy Atom Count1
    Formal Charge0
    Complexity0
    Isotope Atom Count1
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameXenon xe 133
    Active IngredientXenon xe-133
    Dosage FormGas
    RouteInhalation
    Strength20mci/vial; 10mci/vial
    Market StatusPrescription
    CompanyLantheus Medcl

    2 of 2  
    Drug NameXenon xe 133
    Active IngredientXenon xe-133
    Dosage FormGas
    RouteInhalation
    Strength20mci/vial; 10mci/vial
    Market StatusPrescription
    CompanyLantheus Medcl

    4.2 Drug Indication

    Inhalation of Xenon Xe 133 Gas has proved valuable for the evaluation of pulmonary function and for imaging the lungs. It may also be applied to assessment of cerebral flow.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Xenon Xe 133 is a readily diffusible gas which is neither utilized nor produced by the body. It passes through cell membranes and freely exchanges between blood and tissue. It tends to concentrate more in body fat than in blood, plasma, water or protein solutions.

    5.2 FDA Pharmacological Classification
    5.2.1 Active Moiety
    XENON XE-133
    5.2.2 FDA UNII
    X3P9A5HNYF
    5.2.3 Pharmacological Classes
    Radiopharmaceutical Activity [MoA]; Inhalation Diagnostic Agent [EPC]
    5.3 ATC Code

    V - Various

    V09 - Diagnostic radiopharmaceuticals

    V09E - Respiratory system

    V09EX - Other respiratory system diagnostic radiopharmaceuticals

    V09EX03 - Xenon (133Xe) gas

    5.4 Absorption, Distribution and Excretion

    Absorption

    Inhaled Xenon Xe 133 Gas will enter the alveolar wall and enter the pulmonary venous circulation via the capillaries.

    Route of Elimination

    Most of the Xenon Xe 133 that enters the circulation from a single breath is returned to the lungs and exhaled after a single pass through the peripheral circulation.

    5.5 Biological Half-Life

    Half Life 5.245 days

    5.6 Mechanism of Action

    Xenon-133 is used for the diagnostic evaluation of pulmonary function and imaging, as well as assessment of cerebral blood flow. In the concentrations used for diagnostic purposes it is physiologically inactive.