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    Zolazepam Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    PharmaCompass
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    2D Structure
    Also known as: Zolazepam hcl, 33754-49-3, Ci-716, 45sj093q1n, 4-(2-fluorophenyl)-1,3,8-trimethyl-6h-pyrazolo[3,4-e][1,4]diazepin-7-one;hydrochloride, 4-(o-fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo(3,4-e)(1,4)diazepin-7(1h)-one monohydrochloride
    Molecular Formula
    C15H16ClFN4O
    Molecular Weight
    322.76  g/mol
    InChI Key
    NJERAXSSDSHLGE-UHFFFAOYSA-N
    FDA UNII
    45SJ093Q1N
    A pyrazolodiazepinone with pharmacological actions similar to ANTI-ANXIETY AGENTS. It is commonly used in combination with TILETAMINE to obtain immobilization and anesthesia in animals.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-(2-fluorophenyl)-1,3,8-trimethyl-6H-pyrazolo[3,4-e][1,4]diazepin-7-one;hydrochloride
    2.1.2 InChI
    InChI=1S/C15H15FN4O.ClH/c1-9-13-14(10-6-4-5-7-11(10)16)17-8-12(21)19(2)15(13)20(3)18-9;/h4-7H,8H2,1-3H3;1H
    2.1.3 InChI Key
    NJERAXSSDSHLGE-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=NN(C2=C1C(=NCC(=O)N2C)C3=CC=CC=C3F)C.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    45SJ093Q1N
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Ci 716

    2. Ci-716

    3. Ci716

    4. Flupyrazapon

    5. Flupyrazopon

    6. Hydrochloride, Zolazepam

    7. Zolasepam

    8. Zolazepam

    2.3.2 Depositor-Supplied Synonyms

    1. Zolazepam Hcl

    2. 33754-49-3

    3. Ci-716

    4. 45sj093q1n

    5. 4-(2-fluorophenyl)-1,3,8-trimethyl-6h-pyrazolo[3,4-e][1,4]diazepin-7-one;hydrochloride

    6. 4-(o-fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo(3,4-e)(1,4)diazepin-7(1h)-one Monohydrochloride

    7. Pyrazolo(3,4-e)(1,4)diazepin-7(1h)-one, 4-(2-fluorophenyl)-6,8-dihydro-1,3,8-trimethyl-, Monohydrochloride

    8. Unii-45sj093q1n

    9. Zolazepam Hydrochloride [usan]

    10. Einecs 251-668-7

    11. Zolazepam Hydrochloride [usan:usp]

    12. Schembl73002

    13. Zolazepam Hydrochloride (usp)

    14. Chembl2107559

    15. Dtxsid00955349

    16. Zolazepam Hydrochloride(500 Mg)

    17. Zolazepam Hydrochloride [mi]

    18. Zolazepam Hydrochloride [usp-rs]

    19. Zolazepam Hydrochloride [green Book]

    20. Ft-0775057

    21. Zolazepam Hydrochloride [usp Impurity]

    22. D06377

    23. Zolazepam Hydrochloride [usp Monograph]

    24. Q27258863

    25. 4-(2-fluorophenyl)-1,3,8-trimethyl-6h-pyrazolo[3,4-e][1,4]diazepin-7-one,hydrochloride

    26. 4-(2-fluorophenyl)-1,3,8-trimethyl-6,8-dihydropyrazolo[3,4-e][1,4]diazepin-7(1h)-one--hydrogen Chloride (1/1)

    27. 4-(2-fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo(3,4-e)(1,4)diazepin-7(1h)-one Monohydrochloride

    28. 42551-17-7

    29. Pyrazolo(3,4-e)(1,4)diazepin-7(1h)-one, 4-(2-fluorophenyl)-6,8-dihydro-1,3,8-trimethyl-, Hydrochloride

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 322.76 g/mol
    Molecular Formula C15H16ClFN4O
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count1
    Exact Mass322.0996670 g/mol
    Monoisotopic Mass322.0996670 g/mol
    Topological Polar Surface Area50.5 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity455
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Anxiety Agents

    Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

    GABA Modulators

    Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)