| Dupixent | Dupilumab | Regeneron / Sanofi | $4,938 | Biological | Dermatology | To treat adults with moderate-to-severe eczema (atopic dermatitis) | 28/03/2017 |
| Ocrevus | Ocrelizumab | Genentech | $4,088 | Biological | Immunology / Musculoskeletal | To treat patients with relapsing and primary progressive forms of multiple sclerosis | 28/03/2017 |
| Bavencio | Avelumab | EMD Serono / Pfizer | $3,000 | Biological | Dermatology / Oncology | To treat metastatic Merkel cell carcinoma | 23/03/2017 |
| Calquence | Acalabrutinib | Astrazeneca / Acerta Pharma | $2,500 | Chemical | Hematology / Oncology | To treat adults with mantle cell lymphoma | 31/10/2017 |
| Kisqali | Ribociclib Succinate | Novartis Pharms Corp | $2,500 | Chemical | Oncology / Obstetrics / Gynecology (Women’s Health) | To treat postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer | 13/03/2017 |
| Ozempic | Semaglutide | Novo Nordisk | $2,243 | Chemical | Endocrinology / Family Medicine | To improve glycemic control in adults with type 2 diabetes mellitus | 05/12/2017 |
| Hemlibra | Emicizumab | Roche | $2,000 | Biological | Hematology | To prevent or reduce the frequency of bleeding episodes in adult and pediatric patients with hemophilia A who have developed antibodies called Factor VIII (FVIII) inhibitors. | 16/11/2017 |
| Imfinzi | Durvalumab | Astrazeneca / Medimmune | $1,900 | Biological | Urology / Oncology | To treat patients with locally advanced or metastatic urothelial carcinoma | 01/05/2017 |
| Zejula | Niraparib | Tesaro Inc | $1,794 | Chemical | Oncology / Obstetrics / Gynecology (Women’s Health) | For the maintenance treatment for recurrent epithelial ovarian, fallopian tube or primary peritoneal cancers | 27/03/2017 |
| Verzenio | Abemaciclib | Eli Lilly | $1,792 | Chemical | Obstetrics / Gynecology (Women’s Health) / Oncology | To treat certain advanced or metastatic breast cancers | 28/09/2017 |
| Tremfya | Guselkumab | Janssen Biotech | $1,460 | Biological | Dermatology / Immunology | For the treatment of adult patients with moderate-to-severe plaque psoriasis | 13/07/2017 |
| Nerlynx | Neratinib Maleate | Puma Biotech | $1,300 | Chemical | Oncology | For the extended adjuvant treatment of adult patients with early stage HER2-overexpressed/amplified breast cancer, to follow adjuvant trastuzumab-based therapy. | 17/07/2017 |
| Mavyret | Glecaprevir & Pibrentasvir | Abbvie Inc | $1,254 | Chemical | Hepatology (Liver, Pancreatic, Gall Bladder) / Infections and Infectious Diseases | To treat adults with chronic hepatitis C virus | 03/08/2017 |
| Vosevi | Sofosbuvir, Velpatasvir & Voxilaprevir | Gilead Sciences Inc | $1,143 | Chemical | Hepatology (Liver, Pancreatic, Gall Bladder) / Immunology | To treat adults with chronic hepatitis C virus | 18/07/2017 |
| Steglatro | Ertugliflozin | Pfizer / Merck | $1,000 | Chemical | Endocrinology / Family Medicine | To improve glycemic control in adults with type 2 diabetes mellitus | 19/12/2017 |
| Vyzulta | Latanoprostene Bunod | Valeant Pharmaceuticals International / Bausch & Lomb / Nicox | $1,000 | Chemical | Ophthalmology | To treat intraocular pressure in patients with open-angle glaucoma or ocular hypertension | 02/11/2017 |
| Bevyxxa | Betrixaban | Portola Pharms Inc | $1,000 | Chemical | Cardiology / Vascular Diseases | For the prophylaxis of venous thromboembolism (VTE) in adult patients hospitalized for an acute medical illness | 23/06/2017 |
| Kevzara | Sarilumab | Regeneron / Sanofi | $1,000 | Biological | Musculoskeletal / Rheumatology | To treat adult rheumatoid arthritis | 22/05/2017 |
| Ingrezza | Valbenazine Tosylate | Neurocrine Biosciences Inc | $1,000 | Chemical | Neurology | To treat adults with tardive dyskinesia | 11/04/2017 |
| Austedo | Deutetrabenazine | Teva Pharmaceutical Industries | $850 | Chemical | Neurology | For the treatment of chorea associated with Huntington’s disease | 03/04/2017 |
| Alunbrig | Brigatinib | Ariad Pharmaceuticals Inc | $800 | Chemical | Oncology | To treat patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib | 28/04/2017 |
| Aliqopa | Copanlisib Dihydrochloride | Bayer | $700 | Chemical | Oncology / Hematology | To treat adults with relapsed follicular lymphoma | 14/09/2017 |
| Parsabiv | Etelcalcetide | Amgen | $600 | Chemical | Nephrology / Endocrinology | To treat secondary hyperparathyroidism in adult patients with chronic kidney disease undergoing dialysis | 07/02/2017 |
| Xermelo | Telotristat Etiprate | Lexicon Pharmaceuticals Inc | $539 | Chemical | Gastroenterology / Oncology | To treat carcinoid syndrome diarrhea | 28/02/2017 |
| Vabomere | Meropenem & Vaborbactam | The Medicines Company | $520 | Chemical | Urology / Infections and Infectious Diseases | To treat adults with complicated urinary tract infections | 29/08/2017 |
| Idhifa | Enasidenib Mesylate | Celgene Corp / Agios Pharmaceuticals Inc | $500 | Chemical | Oncology / Hematology | To treat relapsed or refractory acute myeloid leukemia | 01/08/2017 |
| Brineura | Cerliponase Alfa | Biomarin Pharm | $500 | Biological | Neurology / Genetic Disease / Musculoskeletal / Pediatrics / Neonatology | To treat a specific form of Batten disease | 27/04/2017 |
| Giapreza | Angiotensin II | La Jolla Pharmaceutical Company | $500 | Chemical | Cardiology / Vascular Diseases | To increase blood pressure in adults with septic or other distributive shock | 21/12/2017 |
| Fasenra | Benralizumab | Astrazeneca / Medimmune | $500 | Biological | Respiratory | For add-on maintenance treatment of patients with severe asthma aged 12 years and older, and with an eosinophilic phenotype | 14/11/2017 |
| Tymlos | Abaloparatide | Radius Health Inc | $450 | Chemical | Musculoskeletal / Obstetrics / Gynecology (Women’s Health) | To treat osteoporosis in postmenopausal women | 28/04/2017 |
| Rydapt | Midostaurin | Novartis Pharms Corp | $436 | Chemical | Oncology / Hematology | To treat acute myeloid leukemia and mastocytosis | 28/04/2017 |
| Xadago | Safinamide Mesylate | Newron Pharmaceutical / Zambon S.P.A / US Worldmeds LLC | $423 | Chemical | Neurology | To treat Parkinson’s disease | 21/03/2017 |
| Baxdela | Delafloxacin Meglumine | Melinta Therapeutics | $400 | Chemical | Dermatology / Infections and Infectious Diseases | To treat patients with acute bacterial skin infections | 19/06/2017 |
| Rhopressa | Netarsudil Dimesylate | Aerie Pharmaceuticals Inc | $350 | Chemical | Ophthalmology | To treat glaucoma or ocular hypertension | 18/12/2017 |
| Trulance | Plecanatide | Synergy Pharmaceuticals | $348 | Chemical | Gastroenterology / Family Medicine | To treat Chronic Idiopathic Constipation (CIC) in adult patients | 19/01/2017 |
| Besponsa | Inotuzumab Ozogamicin | Pfizer | $347 | Biological | Oncology / Hematology | To treat adults with relapsed or refractory acute lymphoblastic leukemia | 17/08/2017 |
| Radicava | Edaravone | Mitsubishi Tanabe | $300 | Chemical | Neurology | To treat patients with amyotrophic lateral sclerosis (ALS) | 05/05/2017 |
| Symproic | Naldemedine | Shionogi / Purdue Pharma | $219 | Chemical | Gastroenterology | For the treatment of opioid-induced constipation | 23/03/2017 |
| Prevymis | Letermovir | Merck & Co. Inc | $200 | Chemical | Infections and Infectious Diseases | To prevent infection after bone marrow transplant | 08/11/2017 |
| Siliq | Brodalumab | Valeant Pharmaceuticals International Inc | $150 | Biological | Dermatology | To treat adults with moderate-to-severe plaque psoriasis | 15/02/2017 |
| Solosec | Secnidazole | Symbiomix Therapeutics | $100 | Chemical | Obstetrics / Gynecology (Women’s Health) / Infections and Infectious Diseases | To treat bacterial vaginosis | 15/09/2017 |
| Emflaza | Deflazacort | Marathon Pharmaceuticals LLC | $100 | Chemical | Pediatrics / Neonatology & Musculoskeletal | To treat patients age 5 years and older with Duchenne muscular dystrophy (DMD) | 09/02/2017 |
| Benznidazole | Benznidazole | Chemo Group / Insud Pharma | $75 | Chemical | Infections and Infectious Diseases | To treat children ages 2 to 12 years old with Chagas disease | 29/08/2017 |
| Mepsevii | Vestronidase Alfa-Vjbk | Ultragenyx Pharm Inc | $70 | Biological | Genetic Disease | To treat pediatric and adult patients with an inherited metabolic condition called mucopolysaccharidosis type VII (MPS VII), also known as Sly syndrome. | 15/11/2017 |
| Macrilen | Macimorelin Acetate | Aeterna Zentaris Inc | $45 | Chemical | Endocrinology | For the diagnosis of adult growth hormone deficiency | 20/12/2017 |
| Xepi | Ozenoxacin | Ferrer International / Medimetriks Pharmaceuticals Inc | $10 | Chemical | Dermatology / Infections and Infectious Diseases | To treat impetigo | 11/12/2017 |
