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Chemistry

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Also known as: 13647-35-3, Modrenal, Vetoryl, Desopan, Modrastane, Trilostanum
Molecular Formula
C20H27NO3
Molecular Weight
329.4  g/mol
InChI Key
KVJXBPDAXMEYOA-CXANFOAXSA-N
FDA UNII
L0FPV48Q5R

Trilostane
Trilostane is a synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex, resulting in the decreased synthesis of mineralocorticoids and glucocorticoids and the decreased conversion of pregnenolone to progesterone. (NCI04)
1 2D Structure

Trilostane

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1S,2R,6R,8S,11S,12S,15S,16S)-5,15-dihydroxy-2,16-dimethyl-7-oxapentacyclo[9.7.0.02,8.06,8.012,16]octadec-4-ene-4-carbonitrile
2.1.2 InChI
InChI=1S/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1
2.1.3 InChI Key
KVJXBPDAXMEYOA-CXANFOAXSA-N
2.1.4 Canonical SMILES
CC12CCC3C(C1CCC2O)CCC45C3(CC(=C(C4O5)O)C#N)C
2.1.5 Isomeric SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CC[C@]45[C@@]3(CC(=C([C@H]4O5)O)C#N)C
2.2 Other Identifiers
2.2.1 UNII
L0FPV48Q5R
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4alpha,5-epoxy-17beta-hydroxy-3-oxoandrostane-2-carbonitrile

2. Modrenal

3. Win 24,540

2.3.2 Depositor-Supplied Synonyms

1. 13647-35-3

2. Modrenal

3. Vetoryl

4. Desopan

5. Modrastane

6. Trilostanum

7. Trilostano

8. Win-24540

9. Win 24,540

10. Chebi:32260

11. L0fpv48q5r

12. Win 24540

13. Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4alpha,5alpha,17beta)-

14. Nsc-758904

15. Dsstox_cid_3706

16. Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4a,5a,17b)-

17. Dsstox_rid_77157

18. Dsstox_gsid_23706

19. (1ar,4ar,4bs,6as,7s,9as,9bs,11as)-2,7-dihydroxy-4a,6a-dimethyl-1a,4,4a,4b,5,6,6a,7,8,9,9a,9b,10,11-tetradecahydrocyclopenta[7,8]phenanthro[1,10a-b]oxirene-3-carbonitrile

20. (1s,2r,6r,8s,11s,12s,15s,16s)-5,15-dihydroxy-2,16-dimethyl-7-oxapentacyclo[9.7.0.0^{2,8}.0^{6,8}.0^{12,16}]octadec-4-ene-4-carbonitrile

21. Modrenal (tn)

22. (1ar,4ar,4bs,6as,7s,9as,9bs,11as)-2,7-dihydroxy-4a,6a-dimethyl-1a,4,4a,4b,5,6,6a,7,8,9,9a,9b,10,11-tetradecahydrocyclopenta[7,8]phenanthro[1,10a-b]oxirene-3-carbonitrile.

23. (1s,2r,6r,8s,11s,12s,15s,16s)-5,15-dihydroxy-2,16-dimethyl-7-oxapentacyclo[9.7.0.02,8.06,8.012,16]octadec-4-ene-4-carbonitrile

24. Desopan (tn)

25. Cas-13647-35-3

26. Trilostane (jan/usan)

27. Trilostanum [inn-latin]

28. Trilostano [inn-spanish]

29. Unii-l0fpv48q5r

30. Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4.alpha.,5.alpha.,17.beta.)-

31. Trilostane [usan:inn:ban:jan]

32. Ncgc00274061-01

33. Einecs 237-133-0

34. Mfcd00199295

35. Win 24450

36. Trilostane [mi]

37. Trilostane [inn]

38. Trilostane [jan]

39. Trilostane [usan]

40. Trilostane [vandf]

41. (4alpha,5alpha,17beta)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile

42. Schembl7517

43. Trilostane [mart.]

44. Trilostane [who-dd]

45. Gtpl6850

46. Trilostane [green Book]

47. Chembl1200907

48. Dtxsid9023706

49. Trilostane [orange Book]

50. Trilostane, >=98% (hplc)

51. 4.alpha.,5-epoxy-3,17.beta.-dihydroxy-5.alpha.-androst-2-ene-2-carbonitrile

52. Hms3884a15

53. Bcp04132

54. Tox21_112454

55. Tox21_302406

56. 4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile

57. Ac-927

58. Bdbm50247882

59. S1404

60. 3,17beta-dihydroxy-4alpha,5-epoxy-5alpha-androst-2-ene-2-carbonitrile

61. 4alpha,5-epoxy-3,17beta-dihydroxy-5alpha-androst-2-ene-2-carbonitrile

62. Akos015964043

63. Akos032947221

64. Tox21_112454_1

65. Zinc100038546

66. Ccg-267803

67. Cs-1707

68. Db01108

69. Ks-1414

70. Nsc 758904

71. (2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-carbonitrile

72. 4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitrile

73. Androstane-2-carbonitrile, 4,5-epoxy-17-hydroxy-3-oxo-, (2-alpha,4-alpha,5-alpha,17-beta)-

74. Ncgc00255201-01

75. Hy-14281

76. Bcp0726000098

77. D01180

78. Ab01274788-01

79. Ab01274788_02

80. 647t353

81. A886681

82. Q907313

83. Q-201884

84. Z1563146079

85. Trilostane; 13647-35-3; Vetoryl; Modrenal; Modrastane

86. (4a,5a,17b)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile

87. 5-alpha-androstane-2-alpha-carbonitrile, 4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 329.4 g/mol
Molecular Formula C20H27NO3
XLogP32.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count0
Exact Mass329.19909372 g/mol
Monoisotopic Mass329.19909372 g/mol
Topological Polar Surface Area76.8 Ų
Heavy Atom Count24
Formal Charge0
Complexity692
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland. This product was withdrawn from the U.S. market in April 1994.


5.2 MeSH Pharmacological Classification

Abortifacient Agents, Steroidal

Steroidal compounds with abortifacient activity. (See all compounds classified as Abortifacient Agents, Steroidal.)


Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)


5.3 ATC Code

H - Systemic hormonal preparations, excl. sex hormones and insulins

H02 - Corticosteroids for systemic use

H02C - Antiadrenal preparations

H02CA - Anticorticosteroids

H02CA01 - Trilostane


5.4 Metabolism/Metabolites

Hepatic.


5.5 Biological Half-Life

8 hours.


5.6 Mechanism of Action

Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.


API SUPPLIERS

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ChemWerth Inc

U.S.A

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Suanfarma

Spain

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Sterling Spa

Italy

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Sterling Spa

Italy

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ORGAMOL PHARMA SOLUTIONS SA

Switzerland

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ORGAMOL PHARMA SOLUTIONS SA

Switzerland

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Symbiotica Specialty Ingredients

Malaysia

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Symbiotica Specialty Ingredients

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ASG Biochem

India

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ASG Biochem

India

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Guangzhou Topwork Chemical

China

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Tianjin Pacific Chemical & Pharmac...

China

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China

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USDMF

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Orgamol Sa

Switzerland

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Orgamol Sa

Switzerland
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 6092

Submission : 1985-11-13

Status : Inactive

Type : II

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Sterling Spa

Italy

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NDC API

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TRILOSTANE

NDC Package Code : 60592-665

Start Marketing Date : 2023-10-13

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1g/g)

Marketing Category : BULK INGREDIENT

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Medisca Inc.

U.S.A
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Medisca Inc.

U.S.A
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TRILOSTANE

NDC Package Code : 38779-2387

Start Marketing Date : 2006-01-06

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1g/g)

Marketing Category : BULK INGREDIENT

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TRILOSTANE

NDC Package Code : 51927-5113

Start Marketing Date : 2020-08-31

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT FOR HUMAN P...

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STERLING SPA

Italy
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STERLING SPA

Italy
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TRILOSTANE

NDC Package Code : 64918-0725

Start Marketing Date : 2014-01-01

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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TRILOSTANE

NDC Package Code : 52128-165

Start Marketing Date : 2013-03-29

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (20kg/20kg)

Marketing Category : BULK INGREDIENT

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TRILOSTANE

NDC Package Code : 52128-165

Start Marketing Date : 2013-03-29

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (12kg/12kg)

Marketing Category : BULK INGREDIENT

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TRILOSTANE

NDC Package Code : 52128-165

Start Marketing Date : 2013-03-29

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (5kg/5kg)

Marketing Category : BULK INGREDIENT

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TRILOSTANE

NDC Package Code : 52128-165

Start Marketing Date : 2013-03-29

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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TRILOSTANE

NDC Package Code : 52128-165

Start Marketing Date : 2013-03-29

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (10kg/10kg)

Marketing Category : BULK INGREDIENT

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TRILOSTANE

NDC Package Code : 26251-0005

Start Marketing Date : 2019-08-02

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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Listed Suppliers

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Virtual BoothChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

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Trilostane

About the Company : Established in 1982, ChemWerth is a US-headquartered full-service generic active pharmaceutical ingredient (API) development and supply company. ChemWerth offers cGMP-quality APIs ...

Established in 1982, ChemWerth is a US-headquartered full-service generic active pharmaceutical ingredient (API) development and supply company. ChemWerth offers cGMP-quality APIs to regulated markets worldwide and has exclusive partnerships for new product development, compliance support and secure supply chain logistics. ChemWerth has access to over 500 APIs and more than 30 manufacturing facilities in the US, Europe, India and China. ChemWerth acts as a regulatory agent for over 25 FDA-approved facilities and sells more than 100 products. It has established its presence in 38 countries. In 2020, ChemWerth filed its 500th DMF with the FDA.
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Suanfarma

Spain
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Virtual BoothSuanFarma is present in all origins: Natural, Chemical & Biotechnological.

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Trilostane

About the Company : Suanfarma founded in 1993, is a B2B life science partner committed to health & innovation by developing, manufacturing, & distributing high-quality APIs for the pharmaceutical indu...

Suanfarma founded in 1993, is a B2B life science partner committed to health & innovation by developing, manufacturing, & distributing high-quality APIs for the pharmaceutical industry innovatively & sustainably. Backed by a robust global network of 12 strategically located local offices, we cater to the needs of over 400 active customers in 70+ countries. At Suanfarma we offer our CDMO capacity for fermentation & chemical synthesis projects, offering a One Stop Shop service with a solid track record, & which allows us to achieve success in the development, scaling, manufacturing, & commercialization of an API, either innovative or generic.
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ASG Biochem

India
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ASG Biochem

India
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Trilostane

About the Company : ASG Biochem Private Limited at Ganganagar near Kolkata, West Bengal, India, is a bulk API manufacturing company of the New Delhi based diversified APEEJAY STYA GROUP. The unit acqu...

ASG Biochem Private Limited at Ganganagar near Kolkata, West Bengal, India, is a bulk API manufacturing company of the New Delhi based diversified APEEJAY STYA GROUP. The unit acquired from AKZO NOBEL N.V., the Netherlands in 2004 is engaged in the synthesis of specialized APIs, in particular, hormones and intermediates.The unit has global exports including intermediates / penultimates to the European Union apart from supply to internal Group companies. In addition, the plant also holds ISO 9001-2008 and ISO 14001:2004 certification from DNV, the Netherlands.The unit has Japan accreditation for manufacturing APIs.
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Trilostane

About the Company : Guangzhou Topwork Chemical Co., Ltd. Specializes in manufacturing corticosteroid and relative intermediates. We provide high quality products and excellent service to our clients a...

Guangzhou Topwork Chemical Co., Ltd. Specializes in manufacturing corticosteroid and relative intermediates. We provide high quality products and excellent service to our clients and have gained a high business reputation in the world market. Topwork gathers a group of energetic, hardworking and much experienced experts. They dedicate their entire efforts to research and development of new products. To guarantee the quality of our products, we have established an international standard quality control system. All of our products conform the latest standard of USP, EP, BP and CP.
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Sterling Spa

Italy
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Sterling Spa

Italy
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Trilostane

About the Company : The Quality Assurance department is the Guardian of Quality within the Company. We have a team dedicated to identifying and implementing new ICH guidelines. Our team is prepared ...

The Quality Assurance department is the Guardian of Quality within the Company. We have a team dedicated to identifying and implementing new ICH guidelines. Our team is prepared to obtain quality objectives which have been universally recognized by Inspection Authorities and the most important Pharmaceutical Companies from around the globe. This system is periodically verified through internal, national and international inspectors who have been able to recognize the high level obtained by the system and the actual achievement of quality objectives multiple times. Sterling has been inspected three times by FDA .
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Trilostane

About the Company : Symbiotica is a Manufacturer of APIs from Malaysia with a cGMP Steroidal facility at Kulim, a Pioneer status from Malaysian Industrial Development Authority and P.I.C/S & W.H.O GMP...

Symbiotica is a Manufacturer of APIs from Malaysia with a cGMP Steroidal facility at Kulim, a Pioneer status from Malaysian Industrial Development Authority and P.I.C/S & W.H.O GMP certified as well as ISO 9001:2000 certified. USDMFs /CTDs have been filed on several products. We have CEPs for Dexamethasone sodium phosphate, Betamethasone valerate, Betamethasone Dipropionate, Clobetasol propionate, Mometasone furoate & Tibolone. Global Market segments include Regulated, Semi- Regulated & Non-regulated Markets. Other Key products are Betamethasones, Clobetasol, Deflazacort, Exemestane, Fluticasone, Fluocinonide.
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Trilostane

About the Company : Founded in 2001, Tianjin Pacific Chemical & Pharmaceutical Co.,Ltd (TPCPC) is located in Jinnan Development Zone of Tianjin,and it covers an area of more than 3900 ㎡ including a ...

Founded in 2001, Tianjin Pacific Chemical & Pharmaceutical Co.,Ltd (TPCPC) is located in Jinnan Development Zone of Tianjin,and it covers an area of more than 3900 ㎡ including a construction area of 9259.55㎡. In 2002, TPCPC gained GMP Certificate issued by China State Food & drug administration.Equipped with advanced production equipments and testing instruments, TPCPC can manufacture a variey ofPhamaceutical Raw Materials with quality products. Highly qualified professionals have been employed to engage in work on research & development, technology, marketing and so on.
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API Reference Price

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[{"dataSource":"API Import","activeIngredients":"TRILOSTANE","year":"2021","qtr":"Q1","strtotime":1612549800,"product":"TRILOSTANE (INVOICE NO-210125-V1104004-C04)","address":"213, LAXMI PLAZA, LAXMI INDL.ESTATE,NEW LINK ROAD,ANDHERI (W),","city":"MUMBAI, MAHARASHTRA","supplier":"XIAMEN ORIGIN BIOTECH ","supplierCountry":"CHINA","foreign_port":"XIAMEN","customer":"ASHISH LIFE SCIENCE PVT LIMITED","customerCountry":"INDIA","quantity":"13.00","actualQuantity":"13","unit":"KGS","unitRateFc":"1650","totalValueFC":"21742.6","currency":"USD","unitRateINR":"121770","date":"06-Feb-2021","totalValueINR":"1583010","totalValueInUsd":"21742.6","indian_port":"BOMBAY AIR","hs_no":"29372900","bill_no":"2656599","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"XIAMEN","supplierAddress":"","customerAddress":"213, LAXMI PLAZA, LAXMI INDL.ESTATE,NEW LINK ROAD,ANDHERI (W),"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1649788200,"product":"TRILOSTANE","address":"PLOT J-137 MIDC TARAPUR,BOISAR PAL GHAR","city":"PALGHAR,MAHARASHTRA","supplier":"XIAMEN ORIGIN BIOTECH ","supplierCountry":"CHINA","foreign_port":"NA","customer":"ASHISH LIFE SCIENCE PVT LIMITED","customerCountry":"INDIA","quantity":"13.00","actualQuantity":"13","unit":"KGS","unitRateFc":"1640","totalValueFC":"21701.8","currency":"USD","unitRateINR":"125952","date":"13-Apr-2022","totalValueINR":"1637376","totalValueInUsd":"21701.8","indian_port":"BOMBAY AIR","hs_no":"29372900","bill_no":"8264305","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT J-137 MIDC TARAPUR,BOISAR PAL GHAR"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1657650600,"product":"TRILOSTANE","address":"S.NO.258,THIRUVANDAVAR VILLAGE,SIR UPINAIYUR, UTHIRAMERUR TALUK","city":"KANCHEEPURAM DISTRICT,TAMIL NADU","supplier":"FELIX PHARMACEUTICALS PVT ","supplierCountry":"CHINA","foreign_port":"NA","customer":"HIBROW HEALTHCARE PRIVATE LIMITED","customerCountry":"INDIA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"6000","totalValueFC":"12057.9","currency":"USD","unitRateINR":"479400","date":"13-Jul-2022","totalValueINR":"958800","totalValueInUsd":"12057.9","indian_port":"MADRAS AIR","hs_no":"29372200","bill_no":"9538078","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"S.NO.258,THIRUVANDAVAR VILLAGE,SIR UPINAIYUR, UTHIRAMERUR TALUK"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1659378600,"product":"TRILOSTANE. ( TL NO. TL\/AZ\/20\/002406 DATE 05.11.2020 ) BATCH NO. TLO 004\/2022. ( 0.10 KGS. ). MFG. 02\/2022. RETEST : 01","address":"ZYDUS CORPORATE PARK, SCHEME NO 63, KHORAJ (GANDHINAGAR), NR. VAISHNODE","city":"AHMEDABAD","supplier":"SYMBIOTICA SPECIALITY INGREDIENTS SDN BHD.","supplierCountry":"MALAYSIA","foreign_port":"NA","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"8000","totalValueFC":"16278.1","currency":"USD","unitRateINR":"647600","date":"02-Aug-2022","totalValueINR":"1295200","totalValueInUsd":"16278.1","indian_port":"AHMEDABAD AIR","hs_no":"29371900","bill_no":"9834661","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"MALAYSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"ZYDUS CORPORATE PARK, SCHEME NO 63, KHORAJ (GANDHINAGAR), NR. VAISHNODE"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1661365800,"product":"VOSY-TRLT-C056-N TRILOSTANE","address":"MURASOLI MARAN TOWERS,73,MRC NAGAR","city":"CHENNAI,TAMILNADU","supplier":"DARSHENG TRADE&TECH DEVELOPMENT CO. LTD","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"SPICEJET LIMITED","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1000","unit":"GMS","unitRateFc":"6","totalValueFC":"6070.3","currency":"USD","unitRateINR":"483","date":"25-Aug-2022","totalValueINR":"483000","totalValueInUsd":"6070.3","indian_port":"GMR HYDERABAD AVIATION-SEZ","hs_no":"29379090","bill_no":"1003866","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"MURASOLI MARAN TOWERS,73,MRC NAGAR"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1667327400,"product":"VOSY-TRLT-C056-N TRILOSTANE","address":"MURASOLI MARAN TOWERS,73,MRC NAGAR","city":"CHENNAI,TAMILNADU","supplier":"DARSHENG TRADE & TECH DEVELOPMENT CO., LTD","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"SPICEJET LIMITED","customerCountry":"INDIA","quantity":"3.00","actualQuantity":"3000","unit":"GMS","unitRateFc":"6","totalValueFC":"18504.5","currency":"USD","unitRateINR":"503.4","date":"02-Nov-2022","totalValueINR":"1510200","totalValueInUsd":"18504.5","indian_port":"GMR HYDERABAD AVIATION-SEZ","hs_no":"29379090","bill_no":"1005123","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"MURASOLI MARAN TOWERS,73,MRC NAGAR"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1669401000,"product":"TRILOSTANE","address":"F 43 DEOLALI PLAZA, LAM ROAD DEOLALI CAMP, DEOLALI Contact No: 9","city":"NASIK","supplier":"TAIZHOU CRENE BIOTECHNOLOGY ","supplierCountry":"CHINA","foreign_port":"NA","customer":"REYAANSH HEALTHCARE","customerCountry":"INDIA","quantity":"3.00","actualQuantity":"3","unit":"KGS","unitRateFc":"1750","totalValueFC":"5313.5","currency":"USD","unitRateINR":"144550","date":"26-Nov-2022","totalValueINR":"433650","totalValueInUsd":"5313.5","indian_port":"BOMBAY AIR","hs_no":"29372900","bill_no":"3479797","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"F 43 DEOLALI PLAZA, LAM ROAD DEOLALI CAMP, DEOLALI Contact No: 9"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1672425000,"product":"TRILOSTANE (TEST LIC. NO. TL\/AZ\/20\/002406) (FOC) FOR R & D PURPOSE NOT FOR SALE","address":"ZYDUS CORPORATE PARK, SCHEME NO 63, KHORAJ (GANDHINAGAR), NR. VAISHNODE","city":"AHMEDABAD","supplier":"SYMBIOTICA SPECIALITY INGREDIENTS ","supplierCountry":"MALAYSIA","foreign_port":"NA","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"0.05","actualQuantity":"50","unit":"GMS","unitRateFc":"8","totalValueFC":"405.6","currency":"USD","unitRateINR":"668.4","date":"31-Dec-2022","totalValueINR":"33420","totalValueInUsd":"405.6","indian_port":"BOMBAY AIR","hs_no":"29372900","bill_no":"3984805","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"MALAYSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"ZYDUS CORPORATE PARK, SCHEME NO 63, KHORAJ (GANDHINAGAR), NR. VAISHNODE"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1679596200,"product":"TRILOSTANE (TEST LIC. NO. TL\/AZ\/20\/002406) FOR R & D PURPOSENOT FOR SALE","address":"ZYDUS CORPORATE PARK, SCHEME NO 63, KHORAJ (GANDHINAGAR), NR. VAISHNODE","city":"AHMEDABAD","supplier":"SYMBIOTICA SPECIALITY INGREDIENTS ","supplierCountry":"MALAYSIA","foreign_port":"NA","customer":"ZYDUS LIFESCIENCES","customerCountry":"INDIA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"8000","totalValueFC":"16282","currency":"USD","unitRateINR":"669600","date":"24-Mar-2023","totalValueINR":"1339200","totalValueInUsd":"16282","indian_port":"BOMBAY AIR","hs_no":"29372900","bill_no":"5198271","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"MALAYSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"ZYDUS CORPORATE PARK, SCHEME NO 63, KHORAJ (GANDHINAGAR), NR. VAISHNODE"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1693852200,"product":"TRILOSTANE (TL NO: TL\/AZ\/20\/002406) FOR R&D PURPOSE NOT FORSALE","address":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H","city":"AHMEDABAD,GUJARAT","supplier":"SYMBIOTICA SPECIALITY INGREDIENTS ","supplierCountry":"MALAYSIA","foreign_port":"PENANG","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"8000","totalValueFC":"4043","currency":"USD","unitRateINR":"671200","date":"05-Sep-2023","totalValueINR":"335600","totalValueInUsd":"4043","indian_port":"Bombay Air","hs_no":"29372900","bill_no":"7686683","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"MALAYSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"PENANG","supplierAddress":"NO. 518, JALAN WAJA 4, TAMAN INDUSTRI WAJA, 09000 KULIM, KEDAH Kulim,Malaysia Malaysia","customerAddress":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1705516200,"product":"TRILOSTANE","address":"F 43 DEOLALI PLAZA, LAM ROAD,DEOLA","city":"NASIK,MAHARASHTRA","supplier":"TAIZHOU CRENE BIOTECHNOLOGY ","supplierCountry":"CHINA","foreign_port":"HANGCHOW (HANGZHOU)","customer":"REYAANSH HEALTHCARE","customerCountry":"INDIA","quantity":"6.00","actualQuantity":"6","unit":"KGS","unitRateFc":"1950","totalValueFC":"11860.2","currency":"USD","unitRateINR":"164287.5","date":"18-Jan-2024","totalValueINR":"985725","totalValueInUsd":"11860.2","indian_port":"Bombay Air","hs_no":"29372900","bill_no":"9716585","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGCHOW (HANGZHOU)","supplierAddress":"ECONOMIC DEVELOPED ZONE OF TAIZHOUZHEJIANG CHINA Guangzhou, , CHINASDNF CHINA","customerAddress":"F 43 DEOLALI PLAZA, LAM ROAD,DEOLA"}]
06-Feb-2021
18-Jan-2024
KGS
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
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Average Price
(USD/KGS)
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FDF Dossiers

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01

Sanofi

France
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Flag France
Digital Content Digital Content

Regulatory Info : DISCN

Registration Country : USA

TRILOSTANE

Brand Name : MODRASTANE

Dosage Form : CAPSULE;ORAL

Dosage Strength : 60MG

Packaging :

Approval Date : 1984-12-31

Application Number : 18719

Regulatory Info : DISCN

Registration Country : USA

Sanofi Company Banner

02

Sanofi

France
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Flag France
Digital Content Digital Content

Regulatory Info : DISCN

Registration Country : USA

TRILOSTANE

Brand Name : MODRASTANE

Dosage Form : CAPSULE;ORAL

Dosage Strength : 30MG

Packaging :

Approval Date : 1984-12-31

Application Number : 18719

Regulatory Info : DISCN

Registration Country : USA

Sanofi Company Banner

03

FNCE 2024
Not Confirmed
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FNCE 2024
Not Confirmed

TRILOSTANE

Brand Name : VETORYL 10 MG

Dosage Form : CAPSULE

Dosage Strength : 10MG

Packaging : 30

Approval Date :

Application Number : 2322005

Regulatory Info : Prescription

Registration Country : Canada

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04

FNCE 2024
Not Confirmed
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FNCE 2024
Not Confirmed

TRILOSTANE

Brand Name : VETORYL 30 MG

Dosage Form : CAPSULE

Dosage Strength : 30MG

Packaging : 30

Approval Date :

Application Number : 2322021

Regulatory Info : Prescription

Registration Country : Canada

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05

FNCE 2024
Not Confirmed
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FNCE 2024
Not Confirmed

TRILOSTANE

Brand Name : VETORYL 60 MG

Dosage Form : CAPSULE

Dosage Strength : 60MG

Packaging : 30

Approval Date :

Application Number : 2322048

Regulatory Info : Prescription

Registration Country : Canada

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06

FNCE 2024
Not Confirmed
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FNCE 2024
Not Confirmed

TRILOSTANE

Brand Name : VETORYL 120 MG

Dosage Form : CAPSULE

Dosage Strength : 120MG

Packaging : 30

Approval Date :

Application Number : 2322056

Regulatory Info : Prescription

Registration Country : Canada

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07

FNCE 2024
Not Confirmed
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FNCE 2024
Not Confirmed

TRILOSTANE

Brand Name : VETORYL 5 MG

Dosage Form : CAPSULE

Dosage Strength : 5MG

Packaging : 30

Approval Date :

Application Number : 2457415

Regulatory Info : Prescription

Registration Country : Canada

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FDA Orange Book

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01

BIOENVISION

France
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Flag France
Digital Content Digital Content

RLD : No

TE Code :

TRILOSTANE

Brand Name : MODRASTANE

Dosage Form : CAPSULE;ORAL

Dosage Strength : 60MG

Approval Date : 1984-12-31

Application Number : 18719

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

Sanofi Company Banner

02

BIOENVISION

France
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Flag France
Digital Content Digital Content

RLD : No

TE Code :

TRILOSTANE

Brand Name : MODRASTANE

Dosage Form : CAPSULE;ORAL

Dosage Strength : 30MG

Approval Date : 1984-12-31

Application Number : 18719

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

Sanofi Company Banner
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