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ACTIVE PHARMA INGREDIENTS

4 API Suppliers, 1 USDMF, 1 EU WC, 20 KDMF, 3 Listed Suppliers, $ API Reference Price

4 API Suppliers
1 USDMF
1 EU WC
20 KDMF
3 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

3 FDF Dossiers, 3 Listed Dossiers

3 FDF Dossiers
3 Listed Dossiers

MARKET PLACE

3 APIs, 2 FDF Dossiers

marketPlace
3 APIs
2 FDF Dossiers

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 150566-71-5, (s)-amlodipine besylate, Levamlodipine besilate, (-)-amlodipine besylate, Levamlodipine besilate [who-dd], S-amlodipine benzenesulfonate

Molecular Formula

C₂₆H₃₁ClN₂O₈S

Molecular Weight

567.1 g/mol

InChI Key

ZPBWCRDSRKPIDG-LMOVPXPDSA-N

FDA UNII

885H5YC40L

1 2D Structure

Levoamlodipine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

benzenesulfonic acid;3-O-ethyl 5-O-methyl (4S)-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

2.1.2 InChI

InChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)/t17-;/m0./s1

2.1.3 InChI Key

ZPBWCRDSRKPIDG-LMOVPXPDSA-N

2.1.4 Canonical SMILES

CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O

2.1.5 Isomeric SMILES

CCOC(=O)C1=C(NC(=C([C@@H]1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O

2.2 Other Identifiers

2.2.1 UNII

885H5YC40L

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 3,5-pyridinedicarboxylic Acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl Ester, (4s)-, Benzenesulfonate (1:1)

2. 3-ethyl 5-methyl (4s)-2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate Benzenesulfonate (1:1)

2.3.2 Depositor-Supplied Synonyms

1. 150566-71-5

2. (s)-amlodipine Besylate

3. Levamlodipine Besilate

4. (-)-amlodipine Besylate

5. Levamlodipine Besilate [who-dd]

6. S-amlodipine Benzenesulfonate

7. Levoamlodipine Besylate

8. 885h5yc40l

9. 3,5-pyridinedicarboxylic Acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl Ester, (4s)-, Benzenesulfonate (1:1)

10. 3,5-pyridinedicarboxylic Acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl Ester, (4s)-, Monobenzenesulfonate

11. Benzenesulfonic Acid;3-o-ethyl 5-o-methyl (4s)-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

12. 3,5-pyridinedicarboxylic Acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl Ester, (4s)-, Benzenesulfonate (1:1)

13. Unii-885h5yc40l

14. (s)-amlodipinebesylate

15. Hy-14744a

16. Cs-0090891

17. 129l824

18. Q27269892

19. (s)-amlodipine Besylate (103129-82-4(free Base))

20. 192583-58-7

2.4 Create Date

2006-10-26

3 Chemical and Physical Properties

Molecular Formula	C₂₆H₃₁ClN₂O₈S
Molecular Weight	567.1 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	11
Exact Mass	566.1489648 g/mol
Monoisotopic Mass	566.1489648 g/mol
Topological Polar Surface Area	163 Å²
Heavy Atom Count	38
Formal Charge	0
Complexity	830
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

API SUPPLIERS

01

Smruthi Organics

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target

Not Confirmed

02

Arene Lifesciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target

Not Confirmed

03

Nishchem International Pvt. Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target

Not Confirmed

04

Lunan Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target

Not Confirmed

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USDMF

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EU WC

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KDMF

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Listed Suppliers

01

02

03

Nishchem International Pvt. Ltd

India

Luxepack

Not Confirmed

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API Reference Price

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