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ACTIVE PHARMA INGREDIENTS

18 API Suppliers, 7 USDMF, 2 CEP/COS, 1 JDMF, 9 NDC API, 15 Listed Suppliers, $ API Reference Price

18 API Suppliers
7 USDMF
2 CEP/COS
1 JDMF
9 NDC API
15 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

11 Drugs in Development

11 Drugs in Development

INTERMEDIATES

3 Intermediates Suppliers

3 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

69 FDF Dossiers, 48 FDA Orange Book, 2 Europe, 5 Canada, 2 Australia, 1 South Africa, 11 Listed Dossiers

69 FDF Dossiers
48 FDA Orange Book
2 Europe
5 Canada
2 Australia
1 South Africa
11 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET, EXTENDED RELEASE;ORAL - EQ 129MG BASE, TABLET, EXTENDED RELEASE;ORAL - EQ 161MG BASE, TABLET, EXTENDED RELEASE;ORAL - EQ 193MG BASE, TABLET, EXTENDED RELEASE;ORAL - EQ 258MG BASE

drugProductComposition
TABLET, EXTENDED RELEASE;ORAL - EQ 129MG BASE
TABLET, EXTENDED RELEASE;ORAL - EQ 161MG BASE
TABLET, EXTENDED RELEASE;ORAL - EQ 193MG BASE
TABLET, EXTENDED RELEASE;ORAL - EQ 258MG BASE

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relatedExcipients
3 Rochem International Inc
18 SPI Pharma
11 DKSH
6 Faran Shimi Pharmaceutical
8 Boai NKY Pharmaceuticals Ltd
13 Gangwal Healthcare
4 Nanjing Well Pharmaceutical
1 Pfanstiehl
4 ACG Worldwide
5 Actylis
1 Aeon Procare
1 Alcedo Pharmachem
8 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
19 BASF
11 Corel Pharma Chem
4 DFE Pharma
1 Finar
7 Gangwal Chemicals
1 Huzhou Sunflower Pharmaceutical
5 Ideal Cures Pvt Ltd
5 Ingredion Pharma Solutions
18 Kerry
4 Kima Chemical
6 Lonza Capsugel
12 Microlex e.U
3 Novo Excipients
3 Pharmatrans-Sanaq
7 Pluviaendo
4 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
2 Qualicaps
30 Roquette
8 Seppic
7 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shanghai Welltone Material Technology Co., Ltd
2 Shijiazhuang Huaxu Pharmaceutical
11 Sigachi Industries
3 The Dow Chemical Company
2 Ulanqab Kema New Material
1 Valens Pharmachem
4 Vasa Pharmachem
1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

82 Fillers, Diluents & Binders, 52 Coating Systems & Additives, 40 Direct Compression, 31 Controlled & Modified Release, 30 Disintegrants & Superdisintegrants, 26 Granulation, 25 Film Formers & Plasticizers, 25 Taste Masking, 24 Thickeners and Stabilizers, 19 Co-Processed Excipients, 18 Lubricants & Glidants, 16 Chewable & Orodispersible Aids, 14 Parenteral, 14 Solubilizers, 9 Empty Capsules, 6 API Stability Enhancers, 6 Emulsifying Agents, 6 Topical, 5 Coloring Agents, 4 Vegetarian Capsules, 3 Rheology Modifiers, 1 Soft Gelatin, 1 Surfactant & Foaming Agents

DIGITAL CONTENT

35 NEWS #PharmaBuzz

media
35 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 6 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
6 Finished Drug Prices

MARKET PLACE

12 APIs, 1 Intermediates

marketPlace
12 APIs
1 Intermediates

PATENTS & EXCLUSIVITIES

144 US Patents, 2 US Exclusivities

patents
144 US Patents
2 US Exclusivities

REF. STANDARDS & IMPURITIES

1 EDQM , 2 USP , 3 Others

otherSolutions
1 EDQM
2 USP
3 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 17

MARKET PLACE

API

FDF

3INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

11DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

144

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

32,334,746

Annual Reports (USD Million)

Finished Drug Prices

266 RELATED EXCIPIENT COMPANIES

457EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 665-66-7, 1-adamantanamine hydrochloride, Amantadine hcl, Symmetrel, 1-aminoadamantane hydrochloride, Adamantan-1-amine hydrochloride

Molecular Formula

C₁₀H₁₈ClN

Molecular Weight

187.71 g/mol

InChI Key

WOLHOYHSEKDWQH-UHFFFAOYSA-N

FDA UNII

M6Q1EO9TD0

An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.

1 2D Structure

Amantadine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

adamantan-1-amine;hydrochloride

2.1.2 InChI

InChI=1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H

2.1.3 InChI Key

WOLHOYHSEKDWQH-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1C2CC3CC1CC(C2)(C3)N.Cl

2.2 Other Identifiers

2.2.1 UNII

M6Q1EO9TD0

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1 Aminoadamantane

2. 1-aminoadamantane

3. Adamantylamine

4. Adekin

5. Al, Amantadin

6. Aman

7. Amanta

8. Amanta Hci Azu

9. Amanta-hci-azu

10. Amantadin Al

11. Amantadin Azu

12. Amantadin Neuraxpharm

13. Amantadin Ratiopharm

14. Amantadin Stada

15. Amantadin-neuraxpharm

16. Amantadin-ratiopharm

17. Amantadina Juventus

18. Amantadina Llorente

19. Amantadine

20. Amantadinneuraxpharm

21. Amantadinratiopharm

22. Amantahciazu

23. Amixx

24. Azu, Amantadin

25. Cerebramed

26. Endantadine

27. Gen Amantadine

28. Gen-amantadine

29. Genamantadine

30. Hydrochloride, Amantadine

31. Infecto Flu

32. Infecto-flu

33. Infectoflu

34. Infex

35. Juventus, Amantadina

36. Llorente, Amantadina

37. Mantadix

38. Midantan

39. Pms Amantadine

40. Pms-amantadine

41. Pmsamantadine

42. Stada, Amantadin

43. Symadine

44. Symmetrel

45. Tregor

46. Viregyt

47. Wiregyt

2.3.2 Depositor-Supplied Synonyms

1. 665-66-7

2. 1-adamantanamine Hydrochloride

3. Amantadine Hcl

4. Symmetrel

5. 1-aminoadamantane Hydrochloride

6. Adamantan-1-amine Hydrochloride

7. 1-adamantylamine Hydrochloride

8. Adamantanamine Hydrochloride

9. Amazolon

10. Midantan

11. Midantane

12. Mydantane

13. Virofral

14. Symadine

15. Influenol

16. Mantadix

17. Trivaline

18. Amantan

19. Virasol

20. Viregyt

21. Virosol

22. Amantadine (hydrochloride)

23. 1-adamantanamine, Hydrochloride

24. Adamantylamine Hydrochloride

25. Aminoadamantane Hydrochloride

26. Adamantine Hydrochloride

27. Exp-105-1

28. 1-adamantanamine Hcl

29. Exp 105-1

30. Nsc 83653

31. Osmolex

32. Mfcd00074723

33. Nsc-83653

34. Adamantan-1-amine;hydrochloride

35. Mls000028731

36. Gp 38026

37. Tricyclo[3.3.1.13,7]decan-1-amine, Hydrochloride

38. M6q1eo9td0

39. Ads-5102

40. Amantadine Hydrochloride (symmetrel)

41. Tricyclo(3.3.1.1(sup 3,7))decan-1-amine, Hydrochloride

42. Smr000059204

43. 665-66-7 (hcl)

44. Tricyclo(3.3.1.13,7)decan-1-amine, Hydrochloride

45. Adamantan-1-aminium Chloride

46. Chebi:2619

47. 1-adamantanamine Hydrochloride;1-adamantylamine Hydrochloride;1-aminoadamantane Hydrochloride

48. 1-adamantanaminehydrochloride

49. 1-aminoadamantene Hydrochloride

50. Nsc83653

51. Einecs 211-560-2

52. Unii-m6q1eo9td0

53. Cerebramed

54. Adamine

55. Hofcomant

56. Lysovir

57. Mantadan

58. Mantadine

59. Nurelin

60. Adamin

61. Ai3-52211

62. Sr-01000075353

63. Symmetrel (tn)

64. Osmolex Er (tn)

65. Gocovri (tn)

66. Amantadinehydrochloride

67. Amantadine Hydrochloride [usan:usp:jan]

68. Opera_id_671

69. Adamantamine Hydrochloride

70. Ec 211-560-2

71. Adamantyl Amine Hydrochloride

72. 1-adamantanamin Hydrochlorid

73. C10h17n.hcl

74. Chembl1569

75. Schembl40713

76. Adamantan-1-aminehydrochloride

77. Mls002153257

78. Mls003899199

79. Spectrum1500110

80. Hy-b0402a

81. 1-aminoada- Mantane Hydrochloride

82. Amy3568

83. Dtxsid50874031

84. N04bb01

85. Hms1920a19

86. Pharmakon1600-01500110

87. Ads-5101

88. Bcp11857

89. Str01017

90. Tox21_500004

91. A3a501

92. Amantadine Hydrochloride [mi]

93. Ccg-38899

94. Nsc755860

95. S2451

96. Tricyclo[3.3.1.13, Hydrochloride

97. Amantadine Hydrochloride (jp17/usp)

98. Amantadine Hydrochloride [jan]

99. Akos015900347

100. Akos015951188

101. Ac-8689

102. Amantadine Hydrochloride [usan]

103. Lp00004

104. Nc00489

105. Nsc-755860

106. Amantadine Hydrochloride [mart.]

107. Amantadine Hydrochloride [vandf]

108. 1-adamantylammonium;1-adamantanamine Hcl

109. Amantadine Hydrochloride [usp-rs]

110. Amantadine Hydrochloride [who-dd]

111. Ncgc00093531-01

112. Ncgc00093531-02

113. Ncgc00093531-03

114. Ncgc00093531-04

115. Ncgc00260689-01

116. Ba166177

117. Smr001370746

118. A0588

119. Eu-0100004

120. Ft-0622248

121. Sw219892-1

122. (3r,5s,7s)-adamantan-1-amine Hydrochloride

123. Amantadine Hydrochloride [orange Book]

124. A 1260

125. Amantadine Hydrochloride [ep Monograph]

126. Amantadine Hydrochloride [usp Monograph]

127. C07939

128. D00777

129. F15409

130. Wln: L66 B6 A B- C 1b Itj Bz &gh

131. A835493

132. Amantadine Hydrochlorid 100 Microg/ml In Methanol

133. Amantadine Hydrochloride 1000 Microg/ml In Methanol

134. J-650095

135. J-650235

136. Q-200621

137. Sr-01000075353-1

138. Tricyclo[3.3.1.1 3,7]decan-1-amine Hydrochloride

139. Tricyclo[3.3.1.13,7]decan-1-amine Hydrochloride

140. Q27105739

141. F3111-1111

142. Tricyclo(3.3.1.13,7)decan-1-amine, Hydrochloride (1:1)

143. Amantadine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

144. Amantadine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

145. Amantadine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

146. 1-aminoadamantane Hydrochloride; 1-adamantanamine Hydrochloride; 1-adamantylamine Hydrochloride

2.4 Create Date

2004-09-16

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₁₈ClN
Molecular Weight	187.71 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Exact Mass	187.1127773 g/mol
Monoisotopic Mass	187.1127773 g/mol
Topological Polar Surface Area	26 Å²
Heavy Atom Count	12
Formal Charge	0
Complexity	144
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Amantadine hydrochloride
Drug Label	Amantadine hydrochloride, USP is designated generically as amantadine hydrochloride and chemically as 1-adamantanamine hydrochloride.Amantadine hydrochloride is a stable white or nearly white crystalline powder, freely soluble in water and soluble in...
Active Ingredient	Amantadine hydrochloride
Dosage Form	Tablet; Syrup; Capsule
Route	Oral
Strength	100mg; 50mg/5ml
Market Status	Prescription
Company	Wockhardt; Silarx; Hi Tech Pharma; Carolina Medcl; Pharm Assoc; Vintage; Usl Pharma; Banner Pharmacaps; Sandoz; Mikart

2 of 2
Drug Name	Amantadine hydrochloride
Drug Label	Amantadine hydrochloride, USP is designated generically as amantadine hydrochloride and chemically as 1-adamantanamine hydrochloride.Amantadine hydrochloride is a stable white or nearly white crystalline powder, freely soluble in water and soluble in...
Active Ingredient	Amantadine hydrochloride
Dosage Form	Tablet; Syrup; Capsule
Route	Oral
Strength	100mg; 50mg/5ml
Market Status	Prescription
Company	Wockhardt; Silarx; Hi Tech Pharma; Carolina Medcl; Pharm Assoc; Vintage; Usl Pharma; Banner Pharmacaps; Sandoz; Mikart

4.2 Drug Indication

Treatment of Parkinson's disease and parkinsonism

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antiparkinson Agents

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)

Antiviral Agents

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

Analgesics, Non-Narcotic

A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)

Dopamine Agents

Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons. (See all compounds classified as Dopamine Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

M2 Protein Inhibitors [MoA]; Influenza A M2 Protein Inhibitor [EPC]

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API Reference Price

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DISTRICT HANGZHOU, CHINA CN","customerAddress":"PLOT NO 23 D , APIIC LALAMKODORU,R"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730053800,"product":"AMANTADINE HYDROCHLORIDE","address":"PLOT NO 23 D , APIIC LALAMKODORU,R","city":"VISAKHAPATNAM,ANDHRA PRADESH","supplier":"HENGDIAN GROUP","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"VINTALABORATORIES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"4000.00","actualQuantity":"4000","unit":"KGS","unitRateFc":"9.9","totalValueFC":"39988.1","currency":"USD","unitRateINR":"840","date":"28-Oct-2024","totalValueINR":"3360060","totalValueInUsd":"39988.1","indian_port":"Madras Sea","hs_no":"29213090","bill_no":"6373936","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"13F, T1 HENGDIAN CENTER, NO.136 FUCHAN ROAD, SHANGCHENG DISTRICT HANGZHOU, CHINA CN","customerAddress":"PLOT NO 23 D , APIIC LALAMKODORU,R"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1732127400,"product":"AMANTADINE HYDROCHLORIDE","address":"KENI BUILDING,","city":"PANAJI, GOA","supplier":"JSC OLPHA","supplierCountry":"LATVIA","foreign_port":"RIGA","customer":"VERGO PHARMA RESEARCH","customerCountry":"INDIA","quantity":"550.00","actualQuantity":"550","unit":"KGS","unitRateFc":"190","totalValueFC":"112439.9","currency":"EUR","unitRateINR":"17252","date":"21-Nov-2024","totalValueINR":"9488600","totalValueInUsd":"112439.9","indian_port":"Bombay Air","hs_no":"29335990","bill_no":"6785281","productDescription":"API","marketType":"REGULATED MARKET","country":"LATVIA","selfForZScoreResived":"Pharma Grade","supplierPort":"RIGA","supplierAddress":"5 RUPNICU STREET, OLAINE, LV-2114 , LATVIA SDNF Latvia","customerAddress":"KENI BUILDING,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1732559400,"product":"AMANTADINE HYDROCHLORIDE ( NOTIFY - GPAX PHARMACEUT ICALS PVTLTD ,PLOTNO-646\/1&2 DABHEL, NANI DAMAN. )","address":"ASTER FLAT NO 402 REGENCY GARDENS,","city":"KHARGHAR,MAHARASHTRA","supplier":"CIDIC CO LTD","supplierCountry":"CHINA","foreign_port":"HANGCHOW (HANGZHOU)","customer":"PROSFORA TECHNOLOGIES PRIVATE ","customerCountry":"INDIA","quantity":"300.00","actualQuantity":"300","unit":"KGS","unitRateFc":"25","totalValueFC":"7585.5","currency":"USD","unitRateINR":"2133.8","date":"26-Nov-2024","totalValueINR":"640125","totalValueInUsd":"7585.5","indian_port":"Bombay Air","hs_no":"29213090","bill_no":"6889744","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGCHOW (HANGZHOU)","supplierAddress":"15\/F, HODO INTERNATIONAL PLAZA, 531 ZHONGSHAN ROAD WUXI 214002 CHINA SDNF CHINA","customerAddress":"ASTER FLAT NO 402 REGENCY GARDENS,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1732905000,"product":"AMANTADINE HCL","address":"PLOT NO 23 D , APIIC LALAMKODORU,R","city":"VISAKHAPATNAM,ANDHRA PRADESH","supplier":"TAIJI IMPORT AND EXPORT (FUZHOU).,LTD","supplierCountry":"CHINA","foreign_port":"N\/A","customer":"VINTALABORATORIES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"5000.00","actualQuantity":"5000","unit":"KGS","unitRateFc":"9.9","totalValueFC":"49976.2","currency":"USD","unitRateINR":"843.5","date":"30-Nov-2024","totalValueINR":"4217400","totalValueInUsd":"49976.2","indian_port":"Vizag Sea","hs_no":"29213090","bill_no":"6970765","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"NO199, BUILDING 7B,2ND FLOOR, LIJIASTRAIT COMMERCIAL CITY,GAISHAN TOWN,CANGSHAN DISTRICT,FUZHOU CITY,","customerAddress":"PLOT NO 23 D , APIIC LALAMKODORU,R"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 1...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 129MG BASE

USFDA APPLICATION NUMBER - 209410

DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 1...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 161MG BASE

USFDA APPLICATION NUMBER - 209410

DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 1...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 193MG BASE

USFDA APPLICATION NUMBER - 209410

DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 2...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 258MG BASE

USFDA APPLICATION NUMBER - 209410

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ACTIVE PHARMA INGREDIENTS

18 API Suppliers

7 USDMF

2 CEP/COS

1 JDMF

9 NDC API

15 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

11 Drugs in Development

INTERMEDIATES

3 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

69 FDF Dossiers

48 FDA Orange Book

2 Europe

5 Canada

2 Australia

1 South Africa

11 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET, EXTENDED RELEASE;ORAL - EQ 129MG BASE

TABLET, EXTENDED RELEASE;ORAL - EQ 161MG BASE

TABLET, EXTENDED RELEASE;ORAL - EQ 193MG BASE

TABLET, EXTENDED RELEASE;ORAL - EQ 258MG BASE

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EXCIPIENTS BY APPLICATIONS

82 Fillers, Diluents & Binders

52 Coating Systems & Additives

40 Direct Compression

31 Controlled & Modified Release

30 Disintegrants & Superdisintegrants