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    Synopsis

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    Chemistry

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    Also known as: 70359-46-5, Alphagan, Brimonidine tartarate, Brimonidine l-tartrate, Lumify, Brimonidinne tartrate
    Molecular Formula
    C15H16BrN5O6
    Molecular Weight
    442.22  g/mol
    InChI Key
    QZHBYNSSDLTCRG-LREBCSMRSA-N
    FDA UNII
    4S9CL2DY2H
    Brimonidine Tartrate
    A quinoxaline derivative and ADRENERGIC ALHPA-2 RECEPTOR AGONIST that is used to manage INTRAOCULAR PRESSURE associated with OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION.
    1 2D Structure

    Brimonidine Tartrate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine;(2R,3R)-2,3-dihydroxybutanedioic acid
    2.1.2 InChI
    InChI=1S/C11H10BrN5.C4H6O6/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8;5-1(3(7)8)2(6)4(9)10/h1-4H,5-6H2,(H2,15,16,17);1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1
    2.1.3 InChI Key
    QZHBYNSSDLTCRG-LREBCSMRSA-N
    2.1.4 Canonical SMILES
    C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br.C(C(C(=O)O)O)(C(=O)O)O
    2.1.5 Isomeric SMILES
    C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
    2.2 Other Identifiers
    2.2.1 UNII
    4S9CL2DY2H
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 5-bromo-6-(2-imidazolin-2-ylamino)quinoxaline D-tartrate

    2. 5-bromo-6-(imidazolidinylideneamino)quinoxaline

    3. 5-bromo-6-(imidazolin-2-ylamino)quinoxaline

    4. Agn 190342

    5. Agn-190342

    6. Agn190342

    7. Alphagan

    8. Alphagan P

    9. Brimonidine

    10. Brimonidine Purite

    11. Brimonidine Tartrate (1:1)

    12. Brimonidine Tartrate (1:1), (s-(r*,r*))-isomer

    13. Brimonidine Tartrate, (r-(r*,r*))-isomer

    14. Bromoxidine

    15. Mirvaso

    16. Ratio Brimonidine

    17. Ratio-brimonidine

    18. Sanrosa

    19. Uk 14,304

    20. Uk 14,304 18

    21. Uk 14,304-18

    22. Uk 14,30418

    23. Uk 14,308

    24. Uk 14304

    25. Uk 14308

    26. Uk-14,304-18

    27. Uk-14,308

    28. Uk-14304

    29. Uk14,30418

    30. Uk14,308

    31. Uk14304

    2.3.2 Depositor-Supplied Synonyms

    1. 70359-46-5

    2. Alphagan

    3. Brimonidine Tartarate

    4. Brimonidine L-tartrate

    5. Lumify

    6. Brimonidinne Tartrate

    7. 5-bromo-n-(4,5-dihydro-1h-imidazol-2-yl)quinoxalin-6-amine (2r,3r)-2,3-dihydroxysuccinate

    8. Mirvaso

    9. 4s9cl2dy2h

    10. Agn 190342-lf

    11. Brimonidine D-tartarate

    12. 5-bromo-n-(4,5-dihydro-1h-imidazol-2-yl)quinoxalin-6-amine;(2r,3r)-2,3-dihydroxybutanedioic Acid

    13. Uk-14304-18

    14. Qoliana

    15. Agn-190342-lf

    16. Bromoxidine Tartrate

    17. (5-bromo-quinoxalin-6-yl)-(4,5-dihydro-1h-imidazol-2-yl)-amine L-tartrate

    18. Brimonidine Purite

    19. Brimonidine Tartrate [usan]

    20. (2r,3r)-2,3-dihydroxybutanedioic Acid; 5-bromo-n-(4,5-dihydro-1h-imidazol-2-yl)quinoxalin-6-amine

    21. 6-quinoxalinamine, 5-bromo-n-(4,5-dihydro-1h-imidazol-2-yl)-, (2r,3r)-2,3-dihydroxybutanedioate (1:1)

    22. 6-quinoxalinamine, 5-bromo-n-(4,5-dihydro-1h-imidazol-2-yl)-, (r-(r*,r*))-2,3-dihydroxybutanedioate (1:1)

    23. 59803-99-5

    24. Ocu300

    25. Unii-4s9cl2dy2h

    26. Ocu-300

    27. Agn-190342lf

    28. Alphagan-p

    29. Cd-07805

    30. Agn 190342lf

    31. Brimonidine Tartrate [usan:jan]

    32. N-(5-bromoquinoxalin-6-yl)imidazolidin-2-imine;(2r,3r)-2,3-dihydroxybutanedioic Acid

    33. Alphagan (tn)

    34. 304 Tartrate

    35. Uk-1430418

    36. 5-bromo-n-

    37. Uk14304 Tartrate

    38. Agn190342 Tartrate

    39. Uk 14304 (tartrate)

    40. Agn190342 (tartrate)

    41. Uk 14,304 (tartrate)

    42. Schembl265607

    43. Chembl1200389

    44. Ex-a5415a

    45. Hy-b0659a

    46. Dtxsid70911371

    47. Brimonidine Tartrate (jan/usan)

    48. Brimonidine Tartrate [jan]

    49. Hms3715p18

    50. Act08633

    51. Brimonidine D-tartrate [mi]

    52. Brimonidine Tartrate [vandf]

    53. Brimonidine Tartrate [mart.]

    54. Mfcd07773072

    55. Brimonidine Tartrate [usp-rs]

    56. Brimonidine Tartrate [who-dd]

    57. Akos016845265

    58. Ccg-221278

    59. Cs-4496

    60. 5-bromo-n-(4,5-dihydro-1h-imidazol-2-yl)quinoxalin-6-amine(2r,3r)-2,3-dihydroxysuccinate

    61. As-18083

    62. Brimonidine Tartrate [orange Book]

    63. Brimonidine Tartrate [ep Monograph]

    64. Brimonidine Tartrate [usp Monograph]

    65. Cd07805/47

    66. Cd-07805/47

    67. Combigan Component Brimonidine Tartrate

    68. A19740

    69. D02076

    70. Simbrinza Component Brimonidine Tartrate

    71. Brimonidine Tartrate Component Of Combigan

    72. 359b465

    73. Brimonidine Tartrate Component Of Simbrinza

    74. (4,5-bihydro-1h-imidazol-2-yl)quinoxalin-6-amine L-tartrate

    75. 5-bromo-n-(4,5-dihydro-1h-imidazol-2-yl) Quinoxalin-6-amine Tartrate

    76. 109826-56-4

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 442.22 g/mol
    Molecular Formula C15H16BrN5O6
    Hydrogen Bond Donor Count6
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count5
    Exact Mass441.02840 g/mol
    Monoisotopic Mass441.02840 g/mol
    Topological Polar Surface Area177 Ų
    Heavy Atom Count27
    Formal Charge0
    Complexity442
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameBrimonidine tartrate
    Drug LabelBrimonidine Tartrate Ophthalmic Solution, 0.2% is a relatively selective alpha-2 adrenergic agonist for ophthalmic use. The chemical name of brimonidine tartrate is 5-bromo-6 (2-imidazolidinylideneamino) quinoxaline L-tartrate. It is a white to sligh...
    Active IngredientBrimonidine tartrate
    Dosage FormSolution/drops; Solution
    Routeophthalmic; Ophthalmic
    Strength0.2%; 0.1%
    Market StatusTentative Approval; Prescription
    CompanyApotex; Bausch And Lomb; Alcon Pharms; Sandoz; Akorn

    2 of 2  
    Drug NameBrimonidine tartrate
    Drug LabelBrimonidine Tartrate Ophthalmic Solution, 0.2% is a relatively selective alpha-2 adrenergic agonist for ophthalmic use. The chemical name of brimonidine tartrate is 5-bromo-6 (2-imidazolidinylideneamino) quinoxaline L-tartrate. It is a white to sligh...
    Active IngredientBrimonidine tartrate
    Dosage FormSolution/drops; Solution
    Routeophthalmic; Ophthalmic
    Strength0.2%; 0.1%
    Market StatusTentative Approval; Prescription
    CompanyApotex; Bausch And Lomb; Alcon Pharms; Sandoz; Akorn

    4.2 Drug Indication

    Mirvaso is indicated for the symptomatic treatment of facial erythema of rosacea in adult patients.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Adrenergic alpha-2 Receptor Agonists

    Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    alpha-Adrenergic Agonist [EPC]; Adrenergic alpha-Agonists [MoA]
    5.3 ATC Code

    D11AX21

    API Reference Price

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OFFICE: NO. 16\/2,","city":"BANGALORE, KARNATAKA","supplier":"C-SQUARED PHARMA","supplierCountry":"IRELAND","foreign_port":"DUBLIN","customer":"SOMERSET THERAPEUTICS LIMITED","customerCountry":"INDIA","quantity":"11.00","actualQuantity":"11","unit":"KGS","unitRateFc":"8800","totalValueFC":"97924","currency":"USD","unitRateINR":"739200","date":"29-Mar-2024","totalValueINR":"8131200","totalValueInUsd":"97924","indian_port":"Bangalore Air","hs_no":"29331999","bill_no":"2800136","productDescription":"API","marketType":"REGULATED MARKET","country":"IRELAND","selfForZScoreResived":"Pharma Grade","supplierPort":"DUBLIN","supplierAddress":"BRIDGE HOUSE UNIT 2 SHEHARD ROAD T12 H2TK CORK IRELAND (IRL) Dublin, ,Ireland Ireland","customerAddress":"REGD. OFFICE: NO. 16\/2,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1715970600,"product":"BRIMONIDINE TARTRATE:--FOR EXAMINATION,TEST OR ANALYSIS PURPOSE ONLY","address":"COMMERCE HOUSE V,BESIDES VODAFONE","city":"AHMEDABAD, GUJARAT. INDIA.","supplier":"MEDICHEM S.A","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"ACULIFE HEALTHCARE","customerCountry":"INDIA","quantity":"0.25","actualQuantity":"0.25","unit":"KGS","unitRateFc":"25000","totalValueFC":"6324.7","currency":"USD","unitRateINR":"2108750","date":"18-May-2024","totalValueINR":"527187.5","totalValueInUsd":"6324.7","indian_port":"Ahmedabad Air","hs_no":"29332990","bill_no":"3546732","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"FRUCTUOS GELABERT,6-8,PLANTA 8 08970, SANT JOANDEPSI,BARCELONA, SPAIN","customerAddress":"COMMERCE HOUSE V,BESIDES VODAFONE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1716489000,"product":"BRIMONIDINE TARTRATE (QTY: 0.090KG, VALUE : USD 765)","address":"PLOT NO.2, MAITRIVIHAR,","city":"HYDERABAD\/ANDHRA PRADESH","supplier":"C-SQUARED PHARMA","supplierCountry":"INDIA","foreign_port":"BASLE","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"0.09","actualQuantity":"0.09","unit":"KGS","unitRateFc":"8500","totalValueFC":"774.1","currency":"USD","unitRateINR":"716975","date":"24-May-2024","totalValueINR":"64527.75","totalValueInUsd":"774.1","indian_port":"Hyderabad Air","hs_no":"29331999","bill_no":"3634539","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BASLE","supplierAddress":"BRIDGE HOUSE UNIT 2, SKEHARD ROAD,T12 H2TK CORK, IRELAND (IRL)SDNF Ireland","customerAddress":"PLOT NO.2, MAITRIVIHAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1719599400,"product":"(F.O.C.) BRIMONIDINE TARTRATE-PM#12593 (FOR TESTING PURPOSEONLY)","address":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK","city":"KURLA, MUMBAI","supplier":"ALLERGAN AESTHETICS","supplierCountry":"ITALY","foreign_port":"DUBLIN","customer":"PIRAMAL PHARMA SOLUTIONS","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"5","unit":"GMS","unitRateFc":"4.5","totalValueFC":"22.9","currency":"USD","unitRateINR":"381.9","date":"29-Jun-2024","totalValueINR":"1909.39","totalValueInUsd":"22.9","indian_port":"Bombay Air","hs_no":"29332990","bill_no":"4255348","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"DUBLIN","supplierAddress":"CASTLEBAR ROAD WESTPORT CO MAYO F28 AW83SDNF Ireland","customerAddress":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721154600,"product":"BRIMONIDINE TARTRATE (BATCH NO: A010360524)","address":"SPARC, TANDALJA,,VADODARA, GUJARAT","city":"VADODARA,GUJARAT","supplier":"M\/S C-SQUARED PHARMA LIMITED","supplierCountry":"INDIA","foreign_port":"FRANKFURT\/MAIN INT\\'L","customer":"SUN PHARMACEUTICAL INDUSTRIES LIMITED","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"10000","totalValueFC":"12577.9","currency":"USD","unitRateINR":"1051402.5","date":"17-Jul-2024","totalValueINR":"1051402.5","totalValueInUsd":"12577.9","indian_port":"Bombay Air","hs_no":"29332990","bill_no":"4558592","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"FRANKFURT\/MAIN INT\\'L","supplierAddress":"BRIDGE HOUSE UNIT 2SKEHARD ROAD,T12 H2TK CORKIRELAND (IRL) IE","customerAddress":"SPARC, TANDALJA,,VADODARA, GUJARAT"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722277800,"product":"BRIMONIDINE TARTRATE - LL\/FP\/ABT-6 - A010350524\/30G","address":"REGD. OFFICE: NO. 16\/2,","city":"BANGALORE, KARNATAKA","supplier":"C-SQUARED PHARMA","supplierCountry":"GERMANY","foreign_port":"FRANKFURT\/MAIN INT\\'L","customer":"SOMERSET THERAPEUTICS LIMITED","customerCountry":"INDIA","quantity":"0.03","actualQuantity":"0.03","unit":"KGS","unitRateFc":"10566.7","totalValueFC":"978.1","currency":"USD","unitRateINR":"2725328.3","date":"30-Jul-2024","totalValueINR":"81759.85","totalValueInUsd":"978.1","indian_port":"Bangalore Air","hs_no":"29332990","bill_no":"4786668","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"FRANKFURT\/MAIN INT\\'L","supplierAddress":"BRIDGE HOUSE UNIT 2 SHEHARD ROAD T12 H2TK CORK IRELAND (IRL) Dublin, ,Ireland Ireland","customerAddress":"REGD. OFFICE: NO. 16\/2,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722364200,"product":"BRIMONIDINE TARTRATE(CAS NO.70359-46-5) LOT NO.104240112","address":"GROUND FLOOR,1ST PRABHAT NAGAR","city":"MUMBAI ,MAHARASHTRA","supplier":"MEDICHEM S.A","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"CIRON GROUP","customerCountry":"INDIA","quantity":"0.30","actualQuantity":"0.3","unit":"KGS","unitRateFc":"21000","totalValueFC":"6398.7","currency":"USD","unitRateINR":"1782902.2","date":"31-Jul-2024","totalValueINR":"534870.65","totalValueInUsd":"6398.7","indian_port":"Bombay Air","hs_no":"29332990","bill_no":"4805051","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"FRUCTUOS GELABERT,6-8,PLANTA 8 08970,SANT JOAN DESPI,BARCELONA,SPAINSDNF Spain","customerAddress":"GROUND FLOOR,1ST PRABHAT NAGAR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723141800,"product":"BRIMONIDINE TARTRATE:--FOR EXAMINATION,TEST OR ANALYSIS PURPOSE ONLY","address":"COMMERCE HOUSE V,BESIDES VODAFONE","city":"AHMEDABAD, GUJARAT. INDIA.","supplier":"MEDICHEM S.A","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"ACULIFE HEALTHCARE","customerCountry":"INDIA","quantity":"0.02","actualQuantity":"0.02","unit":"KGS","unitRateFc":"24000","totalValueFC":"484.1","currency":"USD","unitRateINR":"2030400","date":"09-Aug-2024","totalValueINR":"40608","totalValueInUsd":"484.1","indian_port":"Ahmedabad Air","hs_no":"29332990","bill_no":"4964736","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"FRUCTUOS GELABERT,6-8 08970 SANT JOANDEPSI BARCELONA, SPAIN","customerAddress":"COMMERCE HOUSE V,BESIDES VODAFONE"}]
    08-Jan-2021
    29-Oct-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    FDA Orange Book

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    01

    ABBVIE

    U.S.A
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    American Pharma Summit
    Not Confirmed
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    • EDQM
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    RLD : Yes

    TE Code : AT

    BRIMONIDINE TARTRATE

    Brand Name : ALPHAGAN P

    Dosage Form : SOLUTION/DROPS;OPHTHALMIC

    Dosage Strength : 0.15%

    Approval Date : 2001-03-16

    Application Number : 21262

    RX/OTC/DISCN : RX

    RLD : Yes

    TE Code : AT

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    02

    ABBVIE

    U.S.A
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    American Pharma Summit
    Not Confirmed
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    RLD : Yes

    TE Code : AB

    BRIMONIDINE TARTRATE; TIMOLOL MALEATE

    Brand Name : COMBIGAN

    Dosage Form : SOLUTION/DROPS;OPHTHALMIC

    Dosage Strength : 0.2%;EQ 0.5% BASE

    Approval Date : 2007-10-30

    Application Number : 21398

    RX/OTC/DISCN : RX

    RLD : Yes

    TE Code : AB

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    03

    ABBVIE

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    American Pharma Summit
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    RLD : Yes

    TE Code : AB

    BRIMONIDINE TARTRATE

    Brand Name : ALPHAGAN P

    Dosage Form : SOLUTION/DROPS;OPHTHALMIC

    Dosage Strength : 0.1%

    Approval Date : 2005-08-19

    Application Number : 21770

    RX/OTC/DISCN : RX

    RLD : Yes

    TE Code : AB

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    ALLERGAN

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    RLD : No

    TE Code :

    BRIMONIDINE TARTRATE

    Brand Name : ALPHAGAN

    Dosage Form : SOLUTION/DROPS;OPHTHALMIC

    Dosage Strength : 0.5%

    Approval Date : 1997-03-13

    Application Number : 20490

    RX/OTC/DISCN : DISCN

    RLD : No

    TE Code :

    Abbvie CB

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    ALLERGAN

    U.S.A
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    American Pharma Summit
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    RLD : Yes

    TE Code :

    BRIMONIDINE TARTRATE

    Brand Name : ALPHAGAN

    Dosage Form : SOLUTION/DROPS;OPHTHALMIC

    Dosage Strength : 0.2% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    Approval Date : 1996-09-06

    Application Number : 20613

    RX/OTC/DISCN : DISCN

    RLD : Yes

    TE Code :

    Abbvie CB

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    06

    DR REDDYS LABS SA

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    Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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    RLD : No

    TE Code :

    BRIMONIDINE TARTRATE

    Brand Name : BRIMONIDINE TARTRATE

    Dosage Form : SOLUTION/DROPS;OPHTHALMIC

    Dosage Strength : 0.025%

    Approval Date : 2024-02-16

    Application Number : 216361

    RX/OTC/DISCN : OTC

    RLD : No

    TE Code :

    Dr Reddy Company Banner

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    07

    ALEMBIC

    India
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    ALEMBIC

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    RLD : No

    TE Code : AB

    BRIMONIDINE TARTRATE; TIMOLOL MALEATE

    Brand Name : BRIMONIDINE TARTRATE AND TIMOLOL MALEATE

    Dosage Form : SOLUTION/DROPS;OPHTHALMIC

    Dosage Strength : 0.2%;EQ 0.5% BASE

    Approval Date : 2023-08-25

    Application Number : 215230

    RX/OTC/DISCN : RX

    RLD : No

    TE Code : AB

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    08

    APOTEX

    Canada
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    RLD : No

    TE Code : AB

    BRIMONIDINE TARTRATE

    Brand Name : BRIMONIDINE TARTRATE

    Dosage Form : SOLUTION/DROPS;OPHTHALMIC

    Dosage Strength : 0.1%

    Approval Date : 2022-12-21

    Application Number : 78480

    RX/OTC/DISCN : RX

    RLD : No

    TE Code : AB

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    09

    SANDOZ

    Switzerland
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    SANDOZ

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    RLD : No

    TE Code : AB

    BRIMONIDINE TARTRATE; TIMOLOL MALEATE

    Brand Name : BRIMONIDINE TARTRATE AND TIMOLOL MALEATE

    Dosage Form : SOLUTION/DROPS;OPHTHALMIC

    Dosage Strength : 0.2%;EQ 0.5% BASE

    Approval Date : 2022-04-04

    Application Number : 91087

    RX/OTC/DISCN : RX

    RLD : No

    TE Code : AB

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    10

    SENTISS

    India
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    SENTISS

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    RLD : No

    TE Code : AB

    BRIMONIDINE TARTRATE; TIMOLOL MALEATE

    Brand Name : BRIMONIDINE TARTRATE AND TIMOLOL MALEATE

    Dosage Form : SOLUTION/DROPS;OPHTHALMIC

    Dosage Strength : 0.2%;EQ 0.5% BASE

    Approval Date : 2022-10-31

    Application Number : 91086

    RX/OTC/DISCN : RX

    RLD : No

    TE Code : AB

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    Europe

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    01

    ABBVIE SRL

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    PPS Boston
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    Regulatory Info :

    Registration Country : Italy

    Brimonidine

    Brand Name : ALPHAGAN

    Dosage Form : Eye Drops Solution

    Dosage Strength : 0.20%

    Packaging : 5 ML 0.2% - OPHTHALMIC USE SOLUTION

    Approval Date :

    Application Number :

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    Registration Country : Italy

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    ABBVIE SRL

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    PPS Boston
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    Regulatory Info :

    Registration Country : Italy

    Brimonidine; Timolol

    Brand Name : COMBIGAN

    Dosage Form : Eye Drops

    Dosage Strength : 0.2% + 0.5%

    Packaging : 5 ML 2 MG/ML + 5 MG/ML - OPHTHALMIC USE

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Italy

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    03

    AbbVie AG

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    PPS Boston
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    Regulatory Info :

    Registration Country : Switzerland

    Brimonidini tartras

    Brand Name : Alphagan

    Dosage Form : Gt Opht

    Dosage Strength : 0.10%

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Switzerland

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    AbbVie AG

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    PPS Boston
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    Regulatory Info :

    Registration Country : Switzerland

    Brimonidini tartras

    Brand Name : Alphagan

    Dosage Form : Gt Opht

    Dosage Strength : 0.20%

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Switzerland

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    AbbVie AG

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    PPS Boston
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    Regulatory Info :

    Registration Country : Switzerland

    Brimonidini tartras; Timololum

    Brand Name : Combigan

    Dosage Form : Gtt Opht

    Dosage Strength :

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Switzerland

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    06

    AbbVie AG

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    PPS Boston
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    Regulatory Info :

    Registration Country : Switzerland

    Brimonidini tartras; Timololum

    Brand Name : Combigan

    Dosage Form : Gtt Opht

    Dosage Strength :

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Switzerland

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    07

    Allergan Pharmaceuticals Ireland

    U.S.A
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    PPS Boston
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    Regulatory Info :

    Registration Country : Sweden

    brimonidine tartrate

    Brand Name : Alphagan

    Dosage Form : EYE DROPS, SOLUTION

    Dosage Strength : 0.2% (2 MG / ML)

    Packaging :

    Approval Date :

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    Registration Country : Sweden

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    Allergan Pharmaceuticals Ireland

    U.S.A
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    PPS Boston
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    Several substances refer to content

    Brand Name : Combigan

    Dosage Form : EYE DROPS, SOLUTION

    Dosage Strength : 2 MG / ML + 5 MG / ML

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    Registration Country : Sweden

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    ALLERGAN PHARMACEUTIC.IRELAND

    U.S.A
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    Registration Country : Italy

    Brimonidine Tartrate

    Brand Name : Alphagan

    Dosage Form : Brimonidine 0.2% 5Ml Solution Ophthalmic Use

    Dosage Strength : EYE DROPS 5 ml 2 mg/ml

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    Registration Country : Italy

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    Allergan Solvay Ireland Ltd

    U.S.A
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    Regulatory Info :

    Registration Country : Norway

    Brimonidine Tartrate

    Brand Name : Alphagan

    Dosage Form : Eye drops, resolution

    Dosage Strength : 2 mg/ml

    Packaging : Bottle of plastic with dropping tip

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    Registration Country : Norway

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    Canada

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    ABBVIE CORPORATION

    U.S.A
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    euroPLX 86 Munich
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    Regulatory Info : Prescription

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    BRIMONIDINE TARTRATE

    Brand Name : ALPHAGAN

    Dosage Form : SOLUTION

    Dosage Strength : 0.2%/W/V

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    Approval Date :

    Application Number : 2236876

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    ABBVIE CORPORATION

    U.S.A
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    BRIMONIDINE TARTRATE

    Brand Name : COMBIGAN

    Dosage Form : SOLUTION

    Dosage Strength : 0.2%/W/V

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    Approval Date :

    Application Number : 2248347

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    Registration Country : Canada

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    03

    ABBVIE CORPORATION

    U.S.A
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    euroPLX 86 Munich
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    BRIMONIDINE TARTRATE

    Brand Name : ALPHAGAN P

    Dosage Form : SOLUTION

    Dosage Strength : 0.15%/W/V

    Packaging :

    Approval Date :

    Application Number : 2248151

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    Registration Country : Canada

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    AA PHARMA INC

    U.S.A
    euroPLX 86 Munich
    Not Confirmed
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    AA PHARMA INC

    U.S.A
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    euroPLX 86 Munich
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    Regulatory Info : Prescription

    Registration Country : Canada

    BRIMONIDINE TARTRATE

    Brand Name : BRIMONIDINE P

    Dosage Form : SOLUTION

    Dosage Strength : 0.15%/W/V

    Packaging : 5ML/10ML

    Approval Date :

    Application Number : 2301334

    Regulatory Info : Prescription

    Registration Country : Canada

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    05

    APOTEX INC

    Canada
    euroPLX 86 Munich
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    APOTEX INC

    Canada
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    euroPLX 86 Munich
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    BRIMONIDINE TARTRATE

    Brand Name : APO-BRIMONIDINE-TIMOP

    Dosage Form : SOLUTION

    Dosage Strength : 0.2%

    Packaging : 5ML/10ML

    Approval Date :

    Application Number : 2375311

    Regulatory Info : Prescription

    Registration Country : Canada

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    06

    BAUSCH & LOMB INC

    Canada
    euroPLX 86 Munich
    Not Confirmed
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    BAUSCH & LOMB INC

    Canada
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    euroPLX 86 Munich
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    Regulatory Info : OTC

    Registration Country : Canada

    BRIMONIDINE TARTRATE

    Brand Name : LUMIFY

    Dosage Form : SOLUTION

    Dosage Strength : 0.025%/W/V

    Packaging :

    Approval Date :

    Application Number : 2517698

    Regulatory Info : OTC

    Registration Country : Canada

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    07

    GENERIC MEDICAL PARTNERS INC

    Canada
    euroPLX 86 Munich
    Not Confirmed
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    GENERIC MEDICAL PARTNERS INC

    Canada
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    euroPLX 86 Munich
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    BRIMONIDINE TARTRATE

    Brand Name : MED-BRIMONIDINE

    Dosage Form : SOLUTION

    Dosage Strength : 0.2%/W/V

    Packaging :

    Approval Date :

    Application Number : 2507811

    Regulatory Info : Prescription

    Registration Country : Canada

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    HIKMA CANADA LIMITED

    United Kingdom
    euroPLX 86 Munich
    Not Confirmed
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    HIKMA CANADA LIMITED

    United Kingdom
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    euroPLX 86 Munich
    Not Confirmed
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    Registration Country : Canada

    BRIMONIDINE TARTRATE

    Brand Name : BRIMONIDINE TARTRATE OPHTHALMIC SOLUTION

    Dosage Form : SOLUTION

    Dosage Strength : 0.2%/W/V

    Packaging :

    Approval Date :

    Application Number : 2515377

    Regulatory Info : Prescription

    Registration Country : Canada

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    09

    NOVARTIS PHARMACEUTICALS CANADA INC

    Switzerland
    euroPLX 86 Munich
    Not Confirmed
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    NOVARTIS PHARMACEUTICALS CANADA INC

    Switzerland
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    euroPLX 86 Munich
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    Regulatory Info : Prescription

    Registration Country : Canada

    BRIMONIDINE TARTRATE

    Brand Name : SIMBRINZA

    Dosage Form : SUSPENSION

    Dosage Strength : 0.2%/W/V

    Packaging : 10ML

    Approval Date :

    Application Number : 2435411

    Regulatory Info : Prescription

    Registration Country : Canada

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    10

    Pharmascience Inc.

    Canada
    euroPLX 86 Munich
    Not Confirmed
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    Pharmascience Inc.

    Canada
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    euroPLX 86 Munich
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    Regulatory Info : Generic Dossiers Registered in at Least one EU Member State

    Registration Country : Canada

    Brimonidine Tartrate

    Brand Name :

    Dosage Form : OPHTHALMIC DROPS

    Dosage Strength : 0.2%

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info : Generic Dossiers Registered in at Least one EU Member State

    Registration Country : Canada

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    Australia

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    AbbVie Pty Ltd

    U.S.A
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    euroPLX 86 Munich
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    Regulatory Info :

    Registration Country : Australia

    brimonidine

    Brand Name : Alphagan P 1.5

    Dosage Form : eye drops

    Dosage Strength : 0.15%

    Packaging : 1

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Australia

    Abbvie Company Banner

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    02

    AbbVie Pty Ltd

    U.S.A
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    euroPLX 86 Munich
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    Regulatory Info :

    Registration Country : Australia

    brimonidine

    Brand Name : Enidin

    Dosage Form : eye drops

    Dosage Strength : 0.2%

    Packaging : 1

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Australia

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    03

    AbbVie Pty Ltd

    U.S.A
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    euroPLX 86 Munich
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    Regulatory Info :

    Registration Country : Australia

    brimonidine

    Brand Name : Alphagan

    Dosage Form : eye drops

    Dosage Strength : 0.2%

    Packaging : 1

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Australia

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    04

    AbbVie Pty Ltd

    U.S.A
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    euroPLX 86 Munich
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    Regulatory Info :

    Registration Country : Australia

    brimonidine

    Brand Name : Alphagan P 1.5

    Dosage Form : eye drops

    Dosage Strength : 0.15%

    Packaging : 1

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Australia

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    05

    AbbVie Pty Ltd

    U.S.A
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    euroPLX 86 Munich
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    Regulatory Info :

    Registration Country : Australia

    brimonidine

    Brand Name : Enidin

    Dosage Form : eye drops

    Dosage Strength : 0.2%

    Packaging : 1

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Australia

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    06

    AbbVie Pty Ltd

    U.S.A
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    euroPLX 86 Munich
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    Regulatory Info :

    Registration Country : Australia

    brimonidine

    Brand Name : Alphagan

    Dosage Form : eye drops

    Dosage Strength : 0.2%

    Packaging : 1

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Australia

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    South Africa

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    AbbVie (Pty) Ltd

    U.S.A
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    euroPLX 86 Munich
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    Regulatory Info : Originator

    Registration Country : South Africa

    Brimonidine tartrate

    Brand Name : Alphagan Purite

    Dosage Form : OPD

    Dosage Strength : 4mg/ml

    Packaging : 5X1mg/ml

    Approval Date :

    Application Number :

    Regulatory Info : Originator

    Registration Country : South Africa

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    F.D.C. SA (PTY) LTD

    India
    euroPLX 86 Munich
    Not Confirmed
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    F.D.C. SA (PTY) LTD

    India
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    euroPLX 86 Munich
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    Regulatory Info : Generic

    Registration Country : South Africa

    Brimonidine tartrate

    Brand Name : Agobrim Eye Drops

    Dosage Form : OPD

    Dosage Strength : 2mg/ml

    Packaging : 5X1mg/ml

    Approval Date :

    Application Number :

    Regulatory Info : Generic

    Registration Country : South Africa

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    Gen-Eye (pty) Ltd

    South Africa
    euroPLX 86 Munich
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    Gen-Eye (pty) Ltd

    South Africa
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    euroPLX 86 Munich
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    Regulatory Info : Generic

    Registration Country : South Africa

    Brimonidine

    Brand Name : BRIMOCT

    Dosage Form : OPD

    Dosage Strength : 2mg/ml

    Packaging : 5X1mg/ml

    Approval Date :

    Application Number :

    Regulatory Info : Generic

    Registration Country : South Africa

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    Gen-Eye (Pty) Ltd

    South Africa
    euroPLX 86 Munich
    Not Confirmed
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    Gen-Eye (Pty) Ltd

    South Africa
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    euroPLX 86 Munich
    Not Confirmed
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    Regulatory Info : Generic

    Registration Country : South Africa

    Brimonidine Tartrate

    Brand Name : BRIMOCT CO

    Dosage Form : OPD

    Dosage Strength : 2mg/ ml

    Packaging : 5X1mg/ ml

    Approval Date :

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    Regulatory Info : Generic

    Registration Country : South Africa

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    Novartis South Africa (Pty) Ltd

    Country
    euroPLX 86 Munich
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    Novartis South Africa (Pty) Ltd

    Country
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    euroPLX 86 Munich
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    Regulatory Info : Originator

    Registration Country : South Africa

    Brimonidine

    Brand Name : Simbrinza

    Dosage Form : OPD

    Dosage Strength : 2mg/ml

    Packaging : 5X1mg/ml

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    Regulatory Info : Originator

    Registration Country : South Africa

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    Marketing Authorisation of Various FDFs needed in the UK [ENA13797]
    A company based in the United Kingdom which specializes in the development and licensing of products to improve ocular health is looking for suppliers of Marketing Authorisation of Various FDFs. 1. Bimatoprost (0.1% in 3 ml) Eye Drops 2. Brimonidine Tartrate (2 mg/ ml) + Timolol (5 mg/ ml) Eye Drops 3. Brinzolamide (10 mg /ml) Eye Drops
    30 May 2022

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    30 May 2022

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    30 May 2022

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    Various Finished Formulations needed in Georgia [ENA06601]
    One of the fastest-growing pharmaceutical companies in Georgia that is involved in distribution, retail chains & online publications is looking for European suppliers for Various Finished Formulations: 1. Azapentacene (0.015%) 15 ml Eye Drops 2. Brimonidine (2 mg/ml) 5 ml Eye Drops 3. Brimonidine + Timolol (2 mg + 5 mg/ml) 10 ml Eye Drops 4. Brinzolamide + Brimonidine (10 mg + 2 mg/ml) 5 ml Eye Drops 5. Bromfenac (0.9 mg/ml) 5 ml Eye Drops 6. Carbomer (0.2%) 10 g Eye Gel 7. Chlorpheniramine Maleate + Naphazoline Hydrochloride (0.5 mg + 0.5 mg) 15 ml Eye Drops 8. Ciprofloxacin (0.3%) 5 ml Eye Drops 9. Cromoglicic Acid (4%) 5 ml & 10 ml Eye Drops 10. Dexamethasone (0.1%) 10 ml Eye Drops 11. Dexamethasone (0.1%) 3.5 g Eye Ointment 12. Dextran 70 + Hypromellose (1 mg + 3 mg) 15 ml Eye Drops 13. Fluconazole (0.3%) 5 ml Eye Drops 14. Levofloxacin (5 mg/ml) 5 ml Eye Drops 15. Moxifloxacin (5 mg/ml) 5 ml Eye Drops 16. Neomycin + Polymixin + Dexamethasone (3.5 mg/ml + 6000 IU/ml +1) 3.5 mg/ml Eye Drops 17. Povidone + Polyvinyl alcohol (14 mg + 6 mg) Eye Drops 18. Prednisolone (0.1%) 5 ml Eye Drops 19. Tafluprost (15 mcg/ml) 2.5 ml Eye Drops 20. Tetryzoline (0.1%) 15 ml Eye Drops 21. Tetryzoline + Pheniramine 5 ml Eye Drops 22. Tobramycin (0.3%) 5 ml Eye Drops 23. Tobramycin (3 mg/g) 5 g Eye Ointment 24. Tobramycin + Dexamethasone (3 mg + 1 mg/ml) 5 ml Eye Drops 25. Tobramycin + Dexamethasone (3 mg + 1 mg/g) 5 g Eye Ointment 26. Travoprost + Timolol (40 mcg + 5 mg) 2.5 ml Eye Drops
    18 Feb 2020

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    18 Feb 2020

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    18 Feb 2020

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    Various Finished Formulations needed in the United Kingdom [ENA06585]
    A company that specialises in the supply of various medical equipment such as MRI scanners, CT scanners, ultrasound machines, dialysis consumables is looking for suppliers of Various Finished Formulations: 1. Aflibercept 100 mg/4 ml (5 Units) & 200 mg/8 ml (5 Units) Vials 2. Bevacizumab 100 mg/4 ml (15 Units) & 400 mg/16 ml (15 Units) Vials 3. Bimatoprost 0.01% (1,000 Units), 0.3 mg/mL (1,000 Units) Ophthalmic Solution 4. Bimatoprost 0.3 mg/ml + Timolol 5 mg/ml (400 Units) Ophthalmic Solution 5. Brimonidine 0.15% w/v (1,000 Units) Ophthalmic Solution 6. Brimonidine 2 mg + Brinzolamide 10 mg (1000 Units) Ophthalmic Solution 7. Brimonidine Tartrate 2 mg + Timolol maleate 5 mg (3000 Units) Ophthalmic solution 8. Brinzolamide 1% w/v (1,000 Units) Ophthalmic Solution 9. Brinzolamide 10 mg + Timolol maleate 5 mg (1000 Units) Ophthalmic solution 10. Cyclopentolate Hydrochloride 0.5% (200 Units) & 1% (200 Units) Ophthalmic Solution 11. Epinastine Hydrochloride 0.5 mg/ ml (2,000 Units) Ophthalmic Solution 12. Fluorometholone 0.1 % w/v + Neomycin 0.35 % w/v (232 Units) Ophthalmic solution 13. Latanoprost 50 mcg (400 Units) + Timolol Maleate 6.8 mg (400 Units) Ophthalmic Solution 14. Latanoprost 50 mcg (2000 Units) Ophthalmic Solution 15. Levobunolol 0.5% (1,000 Units) Ophthalmic Solution 16. Moxifloxacin Hydrochloride 5.45 mg/ml (2,000 Units) Ophthalmic Solution 17. Nepafenac 1 mg (1,000 Units) & 3 mg (1,000 Units) Ophthalmic Solution 18. Ofloxacin 0.3% w/v (81 Units) Ophthalmic Solution 19. Olopatadine 1 mg/ml (2,000 Units) Ophthalmic Solution 20. Polyethylene Glycol 400 0.4% + Propylene Glycol 0.3% (1,000 Units) Ophthalmic Solution 21. Polyvinyl Alcohol 1.4% (5,000 Units) Ophthalmic Solution 22. Povidone 0.6% (5,000 Units) Ophthalmic Solution 23. Prednisolone Acetate (microfine suspension) 1% (1,000 Units) Ophthalmic Solution 24. Travoprost 40 mcg/ml + Timolol Maleate 5 mg/ml (400 Units) Ophthalmic Solution 25. Timolol 6.8 mg (400 Units) Ophthalmic Solution 26. Travoprost 0.004 % (2,000 Units) Ophthalmic Solution
    15 Feb 2020

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    15 Feb 2020

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    Various Finished Formulations needed in Mauritius [ENA05773]
    A Renowned Company in the wholesale pharmaceutical industry, offering the best quality pharmaceuticals is looking for suppliers of below finished formulations for the Ministry of Health in Mauritius. Products are required to be delivered in two installments. 1. Bimatoprost Eye Drops (0.03% x 3ml)- Qty: 27,000 units 2. Brimonidine Tartrate Eye Drops (0.15% x 5ml)- Qty: 47,000 units 3. Brinzolamide Eye Drops (1% x 5ml)- Qty: 26,000 units
    18 Nov 2019

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    18 Nov 2019

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    Pantoprazole, Drotaverine and other formulations needed in India [ENA04656]
    One of the leading global pharmaceutical companies is looking for suppliers of the formulation mentioned below: 1. Midazolam Nasal Spray 1.25mg 2. Brinzolamide + Brimonidine Ophthalmic Suspension 3. Azelastine HCL 140 mcg + Fluticasone Propionate 50 mcg 4. Fluticasone 0.05% w/v 5. Pantoprazole MD tablet 20mg- Junior 6. Ondansetron 4mg/ 2mg + Rabeprazole 20mg capsule/ tablet 7. Ondansetron 4mg/ 2mg + Pantoprazole 40mg tablet/ capsule 8. Acebrophylline 200mg SR + Montelukast 10mg IR tablet 9. Drotaverine 20, 40, 80mg tablet.
    19 Jul 2019

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    19 Jul 2019

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    19 Jul 2019

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    ABBVIE

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    Patent Expiration Date : 2024-03-02

    BRIMONIDINE TARTRATE

    US Patent Number : 8858961*PED

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    ALCON LABS INC

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    ALCON LABS INC

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    Patent Expiration Date : 2030-06-17

    BRIMONIDINE TARTRATE; BRINZOLAMIDE

    US Patent Number : 9421265

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    Patent Expiration Date : 2030-10-30

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    US Patent Number : 9044484

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    Patent Expiration Date : 2030-07-14

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    US Patent Number : 9259425

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    Patent Expiration Date : 2029-07-27

    BRIMONIDINE TARTRATE

    US Patent Number : 11596600

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    GALDERMA LABS LP

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    Patent Expiration Date : 2031-03-25

    BRIMONIDINE TARTRATE

    US Patent Number : 9861631

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    Patent Expiration Date : 2031-06-13

    BRIMONIDINE TARTRATE

    US Patent Number : 10201517

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    US Patent Number : 7439241

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    Patent Expiration Date : 2025-05-24

    BRIMONIDINE TARTRATE

    US Patent Number : 8231885

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    Patent Expiration Date : 2031-03-25

    BRIMONIDINE TARTRATE

    US Patent Number : 9861632

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    Application Number : 204708

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