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ACTIVE PHARMA INGREDIENTS

31 API Suppliers, 11 USDMF, 2 EU WC, 2 KDMF, 10 NDC API, 25 Listed Suppliers, $ API Reference Price

31 API Suppliers
11 USDMF
2 EU WC
2 KDMF
10 NDC API
25 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

69 Drugs in Development

69 Drugs in Development

INTERMEDIATES

19 Intermediates Suppliers

19 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

44 FDF Dossiers, 8 FDA Orange Book, 11 Europe, 3 Canada, 12 Australia, 3 South Africa, 7 Listed Dossiers

44 FDF Dossiers
8 FDA Orange Book
11 Europe
3 Canada
12 Australia
3 South Africa
7 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CAPSULE;ORAL - EQ 20MG BASE, CAPSULE;ORAL - EQ 80MG BASE

drugProductComposition
CAPSULE;ORAL - EQ 20MG BASE
CAPSULE;ORAL - EQ 80MG BASE

RELATED EXCIPIENT COMPANIES

1 SPI Pharma, 8 DKSH, 1 Jai Radhe Sales, 2 Faran Shimi Pharmaceutical, 8 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 4 ACG Worldwide, 7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 4 BASF, 10 Corel Pharma Chem, 5 DFE Pharma, 1 Finar, 6 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 2 Ingredion Pharma Solutions, 21 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 11 Microlex e.U, 1 Novo Excipients, 2 Pharmatrans-Sanaq, 2 Pluviaendo, 4 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 14 Roquette, 7 Seppic, 4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 10 Sigachi Industries, 2 The Dow Chemical Company, 1 Valens Pharmachem, 4 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

46 Coating Systems & Additives, 36 Fillers, Diluents & Binders, 24 Disintegrants & Superdisintegrants, 20 Controlled & Modified Release, 19 Thickeners and Stabilizers, 19 Direct Compression, 15 Lubricants & Glidants, 12 Film Formers & Plasticizers, 12 Granulation, 9 Co-Processed Excipients, 9 Empty Capsules, 5 Coloring Agents, 5 Emulsifying Agents, 4 Vegetarian Capsules, 4 API Stability Enhancers, 4 Taste Masking, 4 Topical, 3 Chewable & Orodispersible Aids, 3 Solubilizers, 3 Rheology Modifiers, 1 Parenteral

DIGITAL CONTENT

3 DATA COMPILATION #PharmaFlow, 2 STOCK RECAP #PipelineProspector, 160 NEWS #PharmaBuzz

media
3 DATA COMPILATION #PharmaFlow
2 STOCK RECAP #PipelineProspector
160 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 9 Finished Drug Prices, 10 Annual Reports

globalSalesInformation
2 US Medicaid Prescriptions
9 Finished Drug Prices
10 Annual Reports

MARKET PLACE

7 APIs, 2 FDF Dossiers

marketPlace
7 APIs
2 FDF Dossiers

PATENTS & EXCLUSIVITIES

59 US Patents, 12 US Exclusivities

patents
59 US Patents
12 US Exclusivities

REF. STANDARDS & IMPURITIES

10 Others

otherSolutions
10 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 20,367

MARKET PLACE

API

FDF

19INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

69DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

160

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

923,240,109

Annual Reports (USD Million)

2,414

Finished Drug Prices

160 RELATED EXCIPIENT COMPANIES

257EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 1140909-48-3, Cabozantinib malate, Cabozantinib (s)-malate, Cabometyx, Cabozantinib malate (xl184), Xl184

Molecular Formula

C₃₂H₃₀FN₃O₁₀

Molecular Weight

635.6 g/mol

InChI Key

HFCFMRYTXDINDK-WNQIDUERSA-N

FDA UNII

DR7ST46X58

Cabozantinib S-malate is the s-malate salt form of cabozantinib, an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several RTKs, which are often overexpressed in a variety of cancer cell types, including hepatocyte growth factor receptor (MET), RET (rearranged during transfection), vascular endothelial growth factor receptor types 1 (VEGFR-1), 2 (VEGFR-2), and 3 (VEGFR-3), mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (FLT-3), TIE-2 (TEK tyrosine kinase, endothelial), tropomyosin-related kinase B (TRKB) and AXL. This may result in an inhibition of both tumor growth and angiogenesis, and eventually lead to tumor regression.

1 2D Structure

Cabozantinib

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;(2S)-2-hydroxybutanedioic acid

2.1.2 InChI

InChI=1S/C28H24FN3O5.C4H6O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18;5-2(4(8)9)1-3(6)7/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34);2,5H,1H2,(H,6,7)(H,8,9)/t;2-/m.0/s1

2.1.3 InChI Key

HFCFMRYTXDINDK-WNQIDUERSA-N

2.1.4 Canonical SMILES

COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F.C(C(C(=O)O)O)C(=O)O

2.1.5 Isomeric SMILES

COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F.C([C@@H](C(=O)O)O)C(=O)O

2.2 Other Identifiers

2.2.1 UNII

DR7ST46X58

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Bms 907351

2. Bms-907351

3. Bms907351

4. Cabozantinib

5. Cometriq

6. Xl 184

7. Xl-184

8. Xl184 Cpd

2.3.2 Depositor-Supplied Synonyms

1. 1140909-48-3

2. Cabozantinib Malate

3. Cabozantinib (s)-malate

4. Cabometyx

5. Cabozantinib Malate (xl184)

6. Xl184

7. Cabozantinib (s-malate)

8. Cometriq

9. Cabozantinib S-malate [usan]

10. Dr7st46x58

11. Bms907351

12. Chebi:72319

13. N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (s)-2-hydroxysuccinate

14. Cabometyx (tn)

15. Cometriq (tn)

16. Cabozantinib Malate (jan)

17. 1-n-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;(2s)-2-hydroxybutanedioic Acid

18. Cabozantinib S-malate (usan)

19. Cabozantinib Malate [jan]

20. Unii-dr7st46x58

21. Butanedioic Acid, 2-hydroxy-, (2s)-, Compd. With N-(4-((6,7-dimethoxy-4-quinolinyl)oxy)phenyl)-n'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)

22. Butanedioic Acid, 2-hydroxy-, (2s)-, Compd. With N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-n'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)

23. Xl184 Malate

24. Cabozantinib L-malate

25. Bms907351 Malate

26. Xl184(cabozantinib Malate)

27. Mls006010951

28. Chembl2103868

29. Dtxsid60915949

30. Ex-a2819

31. Mfcd20923480

32. S4001

33. 1140909-48-3 (malate)

34. Akos025401945

35. Cabozantinib S-malate [who-dd]

36. Ccg-270301

37. Cs-0201

38. (2s)-2-hydroxybutanedioic Acid Compd. With N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-n'-(4-fluor

39. (2s)-2-hydroxybutanedioic Acid Compd. With N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-n'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)

40. Ac-27471

41. As-75255

42. Hy-12044

43. Smr004702755

44. Cabozantinib S-malate [orange Book]

45. Sw218093-2

46. D10095

47. Q27139901

48. (2s)-2-hydroxybutanedioic Acid Compd. With N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-n'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

49. (2s)-2-hydroxybutanedioic Acid Compd. With N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-n-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)

50. (2s)-2-hydroxybutanedioic Acid; N'1-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

51. 1,1-cyclopropanedicarboxamide, N'-(4-((6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-n-(4- Fluorophenyl)- Mono((2s)-2-hydroxybutanedioate)

52. Cyclopropane-1,1-dicarboxylic Acid [4-(6,7-dimethoxy-quinoline-4-yloxy)-phenyl]-amide(4-fluoro-phenyl)-amide, (s) Malate Salt

53. N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Mono((2s)-2-hydroxybutanedioate)

54. N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (s)-2-hydroxysuccinate

55. N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (2s)-2-hydroxybutanedioate

2.4 Create Date

2008-12-22

3 Chemical and Physical Properties

Molecular Formula	C₃₂H₃₀FN₃O₁₀
Molecular Weight	635.6 g/mol
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	11
Exact Mass	635.19152232 g/mol
Monoisotopic Mass	635.19152232 g/mol
Topological Polar Surface Area	194 Å²
Heavy Atom Count	46
Formal Charge	0
Complexity	924
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Indication

* Renal Cell Carcinoma (RCC):

Cabometyx is indicated as monotherapy for the treatment of advanced renal cell carcinoma (RCC):

- in treatment-nave adults with intermediate or poor risk,

- in adults following prior vascular endothelial growth factor (VEGF)-targeted therapy.

Cabometyx, in combination with nivolumab, is indicated for the first-line treatment of advanced renal cell carcinoma in adults.

* Hepatocellular Carcinoma (HCC):

Cabometyx is indicated as monotherapy for the treatment of hepatocellular carcinoma (HCC) in adults who have previously been treated with sorafenib.

5 Pharmacology and Biochemistry

5.1 ATC Code

L01EX07

API SUPPLIERS

01

Granules India Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Sichuan Elixir Pharmaceuticals

China

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ChemWerth Inc

U.S.A

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05

LGM Pharma

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BioFlorida Conference

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LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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06

Fermion Oy

Finland

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Dr. Reddy's Laboratories

India

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CPhI India 2024

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DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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Tagoor Laboratories

India

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API Reference Price

[{"dataSource":"API Export","activeIngredients":"CABOZANTINIB","year":"2021","qtr":"Q1","strtotime":1610649000,"product":"CABOZANTINIB (S) MALATE (TAX INV NO:1905 205232 DT:06.01.2021) (GROUP:B SL NO:8 117","address":"8-3-167\/D\/16, KALYAN NAGAR - I,VENGAL RAO NAGAR","city":"HYDERABAD, A.P.","supplier":"MSN LABORATORIES","supplierCountry":"INDIA","foreign_port":"SHANGHAI","customer":"BIOBETTA LIMITED","customerCountry":"CHINA","quantity":"2.40","actualQuantity":"2.4","unit":"KGS","unitRateFc":"17500.3","totalValueFC":"42525.1","currency":"USD","unitRateINR":1295896.6666666667,"date":"15-Jan-2021","totalValueINR":"3110152","totalValueInUsd":"42525.1","indian_port":"HYDERABAD AIR","hs_no":"29337990","bill_no":"7934709","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"8-3-167\/D\/16, KALYAN NAGAR - I,VENGAL RAO NAGAR, HYDERABAD, A.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1635445800,"product":"CABOZANTINIB (S)-MALATE","address":"8-3-167\/D\/16, KALYAN NAGAR - I,VENGAL RAO NAGAR","city":"HYDERABAD, A.P.","supplier":"MSN LABORATORIES","supplierCountry":"INDIA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"BORYUNG PHARMACEUTICAL CO., LTD","customerCountry":"KOREA, REPUBLIC OF","quantity":"0.07","actualQuantity":"0.07","unit":"KGS","unitRateFc":"35000","totalValueFC":"2416.2","currency":"USD","unitRateINR":2585714.2857142854,"date":"29-Oct-2021","totalValueINR":"181000","totalValueInUsd":"2416.2","indian_port":"HYDERABAD AIR","hs_no":"29337990","bill_no":"5663628","productDescription":"API","marketType":"REGULATED MARKET","country":"KOREA,REPUBLIC OF","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"8-3-167\/D\/16, KALYAN NAGAR - I,VENGAL RAO NAGAR, HYDERABAD, A.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1705429800,"product":"CABOZANTINIB (S)-MALATE (FORMS-S)","address":"MSN HOUSE, PLOT NO. C-24,","city":"HYDERABAD. AP","supplier":"MSN LABORATORIES","supplierCountry":"INDIA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"BORYUNG PHARMACEUTICAL CO., LTD","customerCountry":"KOREA, REPUBLIC OF","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"25000","totalValueFC":"12408","currency":"USD","unitRateINR":2062500,"date":"17-Jan-2024","totalValueINR":"1031250","totalValueInUsd":"12408","indian_port":"Hyderabad Air","hs_no":"29337990","bill_no":"6816643","productDescription":"API","marketType":"REGULATED MARKET","country":"KOREA,REPUBLIC OF","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"MSN HOUSE, PLOT NO. C-24,, HYDERABAD. AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1716316200,"product":"CABOZANTINIB (S)-MALATE","address":"MSN HOUSE, PLOT NO. C-24,","city":"HYDERABAD. AP","supplier":"MSN LABORATORIES","supplierCountry":"INDIA","foreign_port":"OSAKA","customer":"MEDISA SHINYAKU INC","customerCountry":"JAPAN","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"35000","totalValueFC":"17190.8","currency":"USD","unitRateINR":2865844,"date":"22-May-2024","totalValueINR":"1432922","totalValueInUsd":"17190.8","indian_port":"Hyderabad Air","hs_no":"29337990","bill_no":"1083317","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"MSN HOUSE, PLOT NO. C-24,, HYDERABAD. AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1718649000,"product":"CABOZANTINIB (S)-MALATE","address":"MSN HOUSE, PLOT NO. C-24,","city":"HYDERABAD. AP","supplier":"MSN LABORATORIES","supplierCountry":"INDIA","foreign_port":"MALTA","customer":"PHARMACARE PREMIUM","customerCountry":"MALTA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"20000","totalValueFC":"20263.7","currency":"USD","unitRateINR":1691602.9399999999,"date":"18-Jun-2024","totalValueINR":"1691602.94","totalValueInUsd":"20263.7","indian_port":"Hyderabad Air","hs_no":"29337990","bill_no":"1761224","productDescription":"API","marketType":"REGULATED MARKET","country":"MALTA","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"MSN HOUSE, PLOT NO. C-24,, HYDERABAD. AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1727721000,"product":"CABOZANTINIB FUMARATE","address":"MSN HOUSE, PLOT NO. C-24,","city":"HYDERABAD. AP","supplier":"MSN LABORATORIES","supplierCountry":"INDIA","foreign_port":"TAIPEI","customer":"ACTAVIS INC","customerCountry":"TAIWAN","quantity":"10.50","actualQuantity":"10.5","unit":"KGS","unitRateFc":"20000","totalValueFC":"207184.5","currency":"USD","unitRateINR":1658000,"date":"01-Oct-2024","totalValueINR":"17409000","totalValueInUsd":"207184.5","indian_port":"Hyderabad Air","hs_no":"29337990","bill_no":"4519010","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"MSN HOUSE, PLOT NO. C-24,, HYDERABAD. AP","customerAddress":""}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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INTERMEDIATES SUPPLIERS

01

Tagoor Laboratories

India

CPhI India 2024

Booth #4.H31

Tagoor's product development expertise, backed by our comprehensive understanding of the processes, helps us offer high-quality APIs.

4-Chloro-6,7-dimethoxyquinoline

CAS Number : 35654-56-9

End Use API : Cabozantinib

02

Tagoor Laboratories

India

CPhI India 2024

Booth #4.H31

Tagoor's product development expertise, backed by our comprehensive understanding of the processes, helps us offer high-quality APIs.

1-((4-Fluoro phenyl) Carbamoyl) Cyclopropane Carbo...

CAS Number : 849217-48-7

End Use API : Cabozantinib

03

Tagoor Laboratories

India

CPhI India 2024

Booth #4.H31

Tagoor's product development expertise, backed by our comprehensive understanding of the processes, helps us offer high-quality APIs.

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline

CAS Number : 190728-25-7

End Use API : Cabozantinib

04

Tagoor Laboratories

India

CPhI India 2024

Booth #4.H31

Tagoor's product development expertise, backed by our comprehensive understanding of the processes, helps us offer high-quality APIs.

Cyclopropane-1,1-dicarboxylic acid methyl ester

CAS Number : 113020-21-6

End Use API : Cabozantinib

05

Tagoor Laboratories

India

CPhI India 2024

Booth #4.H31

Tagoor's product development expertise, backed by our comprehensive understanding of the processes, helps us offer high-quality APIs.

1,1-Cyclopropanedicarboxylic acid

CAS Number : 598-10-7

End Use API : Cabozantinib

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Listed Dossiers

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - CAPSULE;ORAL - EQ 20MG BASE

USFDA APPLICATION NUMBER - 203756

DOSAGE - CAPSULE;ORAL - EQ 80MG BASE

USFDA APPLICATION NUMBER - 203756

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Excipients by Applications

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Coating Systems & Additives

Fillers, Diluents & Binders

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Direct Compression

Lubricants & Glidants

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Granulation

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Emulsifying Agents

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US Medicaid Prescriptions

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Finished Drug Prices

01

Brand Name : Cometriq

France

CPhI India 2024

Not Confirmed

Not Confirmed

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Annual Reports

01 Brand Name : Cabometyx

Cabozantinib

CPhI India 2024

Not Confirmed

02 Brand Name : Cabometyx

Cabozantinib

CPhI India 2024

Not Confirmed

03 Brand Name : Cabometyx

Cabozantinib

CPhI India 2024

Not Confirmed

04 Brand Name : Cabometyx

Cabozantinib

Cabozantinib

CPhI India 2024

Not Confirmed

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Market Place

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APIs

Various APIs needed in Belarus [ENA17152]

A company that focuses on the manufacturing of tablets, capsules, liquids and injectables is looking for suppliers of Various APIs for both development & commercial purposes. The suppliers must support this enquiry with DMF & CoA. 1. Docetaxel (10 kg/ annum) API 2. Cabazitaxel (200 g/ annum) API 3. Oxaliplatin (30 kg/ annum) API 4. Gemcitabine (100 kg/ annum) API 5. Eribulin (200 g/ annum) API 6. Paclitaxel (40 kg/ annum) API 7. Carfilzomib (1 kg/ annum) API 8. Pemetrexed (5 kg/ annum) API 9. Irinotecan (20 kg/ annum) API 10. Carboplatin (90 kg/ annum) API 11. Axitinib (2 kg/ annum) API 12. Cabozantinib (11 kg/ annum) API 13. Vemurafenib (150 kg/ annum) API 14. Cobimetinib (3 kg/ annum) API 15. Tofacitinib (20 kg/ annum) API

24 May 2023

Cabozantinib API needed in Latvia [ENA16749]

A leading company that focuses on manufacturing a wide range of FDFs including neurology, cardiology, infectology and allergology is looking for suppliers of Micronized Cabozantinib API. The required quantity is 1 kg for development & 10 kg - 50 kg for commercial purposes. The suppliers must support this enquiry with CoA.

29 Mar 2023

Various APIs needed in Japan [ENA13594]

A pharmaceutical company that specializes in the manufacturing of pharmaceuticals products & functioning foods is looking for suppliers of Various APIs for development purpose. The required quantity is 80 kg - 100 kg/ annum. 1. JP Grade Dapagliflozin Propylene Glycolate Hydrate (Amorphous form) API 2. JP Grade Cabozantinib API

10 May 2022

Cabozantinib API needed in Korea [ENA13199]

A company that specializes in R&D, manufacturing & marketing of various pharmaceutical products is looking for suppliers of Cabozantinib (S form) API for commercial purpose.

04 Apr 2022

USP and Ph. Eur Grade Cabozantinib S-malate API needed in Germany [ENA07223]

A nanotechnology-based drug development company focused on reformulations and reinventions of established drugs is looking for suppliers of USP and Ph. Eur Grade Cabozantinib S-malate API. The suppliers must support this enquiry with USDMF, GMP and EP/ASMF/EDMF. The final market is Europe & the US.

05 May 2020

Apalutamide, Cabozantinib malate and other APIs needed in Bangladesh [ENA02773]

M.R Trading Corporation, Bangladesh is looking for suppliers of following APIs: 1. Apalutamide 2. Cabozantinib malate 3. Ruxolitinib Phosphate 4. Trabectedin INN 5. Venetoclax 6. Aflibercept Interested suppliers can contact Masud via Mob: +880 01725219963 or Email: info@mrtcbd.com.

28 Nov 2018

Enquiry// Various Active Pharmaceutical Ingredients needed in Bangladesh [ENA01104]

Rainbow Pacific Ltd, a distribution company in Bangladesh is looking for suppliers of following APIs for their client: 1. Alectinib HCl INN (Micronized) 50 kg 2. Olaparib 14.5 kg 3. Apixaban 500 g 4. Cabozantinib Malate 4 kg 5. Neratinib Maleate 5 kg 6. Brigatinib 4.5 kg 7. Ponatinib HCl 2.5 kg Interested suppliers should contact Ms Mallika via Email: rainpac1@gmail.com or Tel: 88028033857.

17 Jul 2018

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FDF DOSSIERS

CABOZANTINIB S-MALATE

CPhI India 2024

Not Confirmed

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US Exclusivities

Not Confirmed

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REF. STANDARDS & IMPURITIES

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Others

01

Aozeal Certified Standards

U.S.A

U.S.A

CPhI India 2024

Not Confirmed

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ABOUT THIS PAGE

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

31 API Suppliers

11 USDMF

2 EU WC

2 KDMF

10 NDC API

25 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

69 Drugs in Development

INTERMEDIATES

19 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

44 FDF Dossiers

8 FDA Orange Book

11 Europe

3 Canada

12 Australia

3 South Africa

7 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CAPSULE;ORAL - EQ 20MG BASE

CAPSULE;ORAL - EQ 80MG BASE

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10 Sigachi Industries

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4 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

46 Coating Systems & Additives

36 Fillers, Diluents & Binders

24 Disintegrants & Superdisintegrants

20 Controlled & Modified Release

19 Thickeners and Stabilizers

19 Direct Compression

15 Lubricants & Glidants

12 Film Formers & Plasticizers

12 Granulation

9 Co-Processed Excipients

9 Empty Capsules

5 Coloring Agents

5 Emulsifying Agents

4 Vegetarian Capsules

4 API Stability Enhancers

4 Taste Masking

4 Topical

3 Chewable & Orodispersible Aids