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    Chemistry

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    Also known as: Colestid, Cholestabyl, 37296-80-3, Colestipol hydrochloride [usan:usp], Lestid, Flavored colestid
    Molecular Formula
    C8H24ClN5
    Molecular Weight
    225.76  g/mol
    InChI Key
    GACQNVJDWUAPFY-UHFFFAOYSA-N
    Colestipol
    Highly crosslinked and insoluble basic anion exchange resin used as anticholesteremic. It may also may reduce triglyceride levels.
    1 2D Structure

    Colestipol

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N'-[2-[2-(2-aminoethylamino)ethylamino]ethyl]ethane-1,2-diamine;hydrochloride
    2.1.2 InChI
    InChI=1S/C8H23N5.ClH/c9-1-3-11-5-7-13-8-6-12-4-2-10;/h11-13H,1-10H2;1H
    2.1.3 InChI Key
    GACQNVJDWUAPFY-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C(CNCCNCCNCCN)N.Cl
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Colestid

    2. Colestipol

    3. Colestipol Hcl

    4. Hcl, Colestipol

    5. Hydrochloride, Colestipol

    6. U 26,597 A

    7. U-26,597 A

    8. U26,597 A

    2.2.2 Depositor-Supplied Synonyms

    1. Colestid

    2. Cholestabyl

    3. 37296-80-3

    4. Colestipol Hydrochloride [usan:usp]

    5. Lestid

    6. Flavored Colestid

    7. N'-[2-[2-(2-aminoethylamino)ethylamino]ethyl]ethane-1,2-diamine;hydrochloride

    8. U-26597a

    9. Unii-x7d10k905g

    10. Tetraethylenepentamine Hcl

    11. Copolymer Of Diethylenetriamine And 1-chloro-2,3-epoxypropane, Hydrochloride (with Approximately 1 Out Of 5 Amine Nitrogens Protonated)

    12. Schembl284758

    13. Dtxsid40190737

    14. X7d10k905g

    15. Ft-0749664

    2.3 Create Date
    2005-08-09
    3 Chemical and Physical Properties
    Molecular Weight 225.76 g/mol
    Molecular Formula C8H24ClN5
    Hydrogen Bond Donor Count6
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count10
    Exact Mass225.1720235 g/mol
    Monoisotopic Mass225.1720235 g/mol
    Topological Polar Surface Area88.1 Ų
    Heavy Atom Count14
    Formal Charge0
    Complexity78.6
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameColestipol hydrochloride
    Drug LabelCOLESTID Granules and FLAVORED COLESTID Granules contain colestipol hydrochloride, which is a lipid lowering agent for oral use. Colestipol hydrochloride is an insoluble, high molecular weight basic anion-exchange copolymer of diethylenetriamine and...
    Active IngredientColestipol hydrochloride
    Dosage FormTablet; Granule
    RouteOral
    Strength1gm; 5gm/scoopful; 5gm/packet
    Market StatusPrescription
    CompanyImpax Labs

    2 of 4  
    Drug NameFlavored colestid
    Drug LabelCOLESTID Granules and FLAVORED COLESTID Granules contain colestipol hydrochloride, which is a lipid lowering agent for oral use. Colestipol hydrochloride is an insoluble, high molecular weight basic anion-exchange copolymer of diethylenetriamine and...
    Active IngredientColestipol hydrochloride
    Dosage FormGranule
    RouteOral
    Strength5gm/scoopful; 5gm/packet
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    3 of 4  
    Drug NameColestipol hydrochloride
    Drug LabelCOLESTID Granules and FLAVORED COLESTID Granules contain colestipol hydrochloride, which is a lipid lowering agent for oral use. Colestipol hydrochloride is an insoluble, high molecular weight basic anion-exchange copolymer of diethylenetriamine and...
    Active IngredientColestipol hydrochloride
    Dosage FormTablet; Granule
    RouteOral
    Strength1gm; 5gm/scoopful; 5gm/packet
    Market StatusPrescription
    CompanyImpax Labs

    4 of 4  
    Drug NameFlavored colestid
    Drug LabelCOLESTID Granules and FLAVORED COLESTID Granules contain colestipol hydrochloride, which is a lipid lowering agent for oral use. Colestipol hydrochloride is an insoluble, high molecular weight basic anion-exchange copolymer of diethylenetriamine and...
    Active IngredientColestipol hydrochloride
    Dosage FormGranule
    RouteOral
    Strength5gm/scoopful; 5gm/packet
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anion Exchange Resins

    High-molecular-weight insoluble polymers that contain functional cationic groups capable of undergoing exchange reactions with anions. (See all compounds classified as Anion Exchange Resins.)

    Hypolipidemic Agents

    Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS. (See all compounds classified as Hypolipidemic Agents.)

    Sequestering Agents

    Compounds that bind to and reduce the biological availability of a chemical or pharmaceutical agent. (See all compounds classified as Sequestering Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Bile-acid Binding Activity [MoA]; Bile Acid Sequestrant [EPC]

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    05-Apr-2021
    01-Aug-2024
    KGS
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