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ACTIVE PHARMA INGREDIENTS

26 API Suppliers, 11 USDMF, 8 CEP/COS, 5 KDMF, 7 NDC API, 12 Listed Suppliers, $ API Reference Price

26 API Suppliers
11 USDMF
8 CEP/COS
5 KDMF
7 NDC API
12 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

14 Drugs in Development

14 Drugs in Development

FINISHED DOSAGE FORMULATIONS

205 FDF Dossiers, 78 FDA Orange Book, 36 Europe, 2 Canada, 38 Australia, 13 South Africa, 38 Listed Dossiers

205 FDF Dossiers
78 FDA Orange Book
36 Europe
2 Canada
38 Australia
13 South Africa
38 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CAPSULE;ORAL - EQ 100MG BASE, CAPSULE;ORAL - EQ 150MG BASE, CAPSULE;ORAL - EQ 50MG BASE, CAPSULE;ORAL - EQ 75MG BASE, CAPSULE;ORAL - 40MG

drugProductComposition
CAPSULE;ORAL - EQ 100MG BASE
CAPSULE;ORAL - EQ 150MG BASE
CAPSULE;ORAL - EQ 50MG BASE
CAPSULE;ORAL - EQ 75MG BASE
CAPSULE;ORAL - 40MG

RELATED EXCIPIENT COMPANIES

1 Evonik, 3 Rochem International Inc, 7 SPI Pharma, 2 Seqens, 9 DKSH, 2 Jai Radhe Sales, 7 Faran Shimi Pharmaceutical, 5 Boai NKY Pharmaceuticals Ltd, 14 Gangwal Healthcare, 7 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 4 ACG Worldwide, 11 Actylis, 2 Aeon Procare, 2 Alcedo Pharmachem, 10 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 34 BASF, 1 Clariant, 14 Corel Pharma Chem, 7 DFE Pharma, 3 Finar, 13 Gangwal Chemicals, 11 Ideal Cures Pvt Ltd, 4 Ingredion Pharma Solutions, 38 Kerry, 5 Kima Chemical, 6 Lonza Capsugel, 17 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nomisma Healthcare, 4 Novo Excipients, 4 Pharmatrans-Sanaq, 8 Pluviaendo, 4 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 32 Roquette, 14 Seppic, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 12 Sigachi Industries, 4 The Dow Chemical Company, 2 Ulanqab Kema New Material, 2 Valens Pharmachem, 4 Vasa Pharmachem, 1 Vertellus, 1 Zhejiang Huakang Pharmaceutical

relatedExcipients
1 Evonik
3 Rochem International Inc
7 SPI Pharma
2 Seqens
9 DKSH
2 Jai Radhe Sales
7 Faran Shimi Pharmaceutical
5 Boai NKY Pharmaceuticals Ltd
14 Gangwal Healthcare
7 Nanjing Well Pharmaceutical
1 Pfanstiehl
4 ACG Worldwide
11 Actylis
2 Aeon Procare
2 Alcedo Pharmachem
10 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
34 BASF
1 Clariant
14 Corel Pharma Chem
7 DFE Pharma
3 Finar
13 Gangwal Chemicals
11 Ideal Cures Pvt Ltd
4 Ingredion Pharma Solutions
38 Kerry
5 Kima Chemical
6 Lonza Capsugel
17 Microlex e.U
1 Nanjing Bold Chemical
2 Nomisma Healthcare
4 Novo Excipients
4 Pharmatrans-Sanaq
8 Pluviaendo
4 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
2 Qualicaps
32 Roquette
14 Seppic
5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shijiazhuang Huaxu Pharmaceutical
12 Sigachi Industries
4 The Dow Chemical Company
2 Ulanqab Kema New Material
2 Valens Pharmachem
4 Vasa Pharmachem
1 Vertellus
1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

90 Fillers, Diluents & Binders, 73 Coating Systems & Additives, 43 Controlled & Modified Release, 43 Disintegrants & Superdisintegrants, 43 Direct Compression, 39 Thickeners and Stabilizers, 34 Solubilizers, 31 Granulation, 28 Film Formers & Plasticizers, 22 Parenteral, 22 Taste Masking, 18 Lubricants & Glidants, 18 Co-Processed Excipients, 18 Topical, 12 Chewable & Orodispersible Aids, 9 Empty Capsules, 8 Rheology Modifiers, 8 Emulsifying Agents, 6 API Stability Enhancers, 5 Surfactant & Foaming Agents, 5 Coloring Agents, 4 Vegetarian Capsules, 1 Soft Gelatin

DIGITAL CONTENT

46 NEWS #PharmaBuzz

media
46 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

5 US Medicaid Prescriptions, 51 Finished Drug Prices

globalSalesInformation
5 US Medicaid Prescriptions
51 Finished Drug Prices

MARKET PLACE

36 APIs, 8 FDF Dossiers, 1 Intermediates

marketPlace
36 APIs
8 FDF Dossiers
1 Intermediates

PATENTS & EXCLUSIVITIES

6 US Patents, 3 Health Canada Patents

patents
6 US Patents
3 Health Canada Patents

REF. STANDARDS & IMPURITIES

2 EDQM , 2 USP , 3 Others

otherSolutions
2 EDQM
2 USP
3 Others

ANALYTICAL

1 BioAnalytical Methods

otherMethods
1 BioAnalytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 91

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

205

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

14DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

37,303,713

Annual Reports (USD Million)

Finished Drug Prices

344 RELATED EXCIPIENT COMPANIES

580EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 564-25-0, Vibramycin, Doxytetracycline, Doxycycline (anhydrous), Doxiciclina, Doxycyclinum

Molecular Formula

C₂₂H₂₄N₂O₈

Molecular Weight

444.4 g/mol

InChI Key

SGKRLCUYIXIAHR-AKNGSSGZSA-N

FDA UNII

334895S862

A synthetic tetracycline derivative with similar antimicrobial activity.

Doxycycline anhydrous is a Tetracycline-class Drug.

1 2D Structure

Doxycycline

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide

2.1.2 InChI

InChI=1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25-27,30,32H,1-3H3,(H2,23,31)/t7-,10+,14+,15-,17-,22-/m0/s1

2.1.3 InChI Key

SGKRLCUYIXIAHR-AKNGSSGZSA-N

2.1.4 Canonical SMILES

CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O

2.1.5 Isomeric SMILES

C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O

2.2 Other Identifiers

2.2.1 UNII

334895S862

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4s-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))-

2. Alpha 6 Deoxyoxytetracycline

3. Alpha-6-deoxyoxytetracycline

4. Atridox

5. Bmy 28689

6. Bmy-28689

7. Bmy28689

8. Bu 3839t

9. Bu-3839t

10. Bu3839t

11. Doryx

12. Doxycycline Calcium

13. Doxycycline Calcium Salt (1:2)

14. Doxycycline Chinoin

15. Doxycycline Hemiethanolate

16. Doxycycline Hyclate

17. Doxycycline Monohydrate

18. Doxycycline Monohydrochloride, 6 Epimer

19. Doxycycline Monohydrochloride, 6-epimer

20. Doxycycline Monohydrochloride, Dihydrate

21. Doxycycline Phosphate (1:1)

22. Doxycycline-chinoin

23. Hydramycin

24. Oracea

25. Periostat

26. Vibra Tabs

27. Vibra-tabs

28. Vibramycin

29. Vibramycin Novum

30. Vibravenos

2.3.2 Depositor-Supplied Synonyms

1. 564-25-0

2. Vibramycin

3. Doxytetracycline

4. Doxycycline (anhydrous)

5. Doxiciclina

6. Doxycyclinum

7. Monodox

8. Doxycycline Hyclate

9. Doxycycline Anhydrous

10. 6alpha-deoxy-5-oxytetracycline

11. 5-hydroxy-alpha-6-deoxytetracycline

12. Vibramycine

13. Doxychel

14. 6-alpha-deoxy-5-oxytetracycline

15. Doxycyclin

16. Alpha-6-deoxy-5-hydroxytetracycline

17. Bmy-28689

18. Anhydrous Doxycycline

19. Liviatin

20. Doxycycline (inn)

21. Doxy-caps

22. Deoxymykoin

23. Dossiciclina

24. Doxitard

25. Doxivetin

26. Doxycen

27. Investin

28. Chebi:50845

29. Doxy-puren

30. Alpha-doxycycline

31. Doxy-tabs

32. Alpha-6-deoxyoxytetracycline

33. Mmv000011

34. (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide

35. Doxysol

36. Jenacyclin

37. 6-deoxyoxytetracycline

38. Dossiciclina [dcit]

39. Doxiciclina [italian]

40. Doxycycline [inn]

41. (4s,4ar,5s,5ar,6r,12as)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

42. 2-naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4s,4ar,5s,5ar,6r,12as)-

43. Doxycyclinum [inn-latin]

44. Doxycycline (internal Use)

45. Doxiciclina [inn-spanish]

46. 334895s862

47. Bu-3839t

48. Zenavod

49. Doxcycline Anhydrous

50. Oxytetracycline, 6-deoxy-

51. Doxycycline (tn)

52. Doxychel (tn)

53. Vivox (*hyclate)

54. Dmsc (*fosfatex)

55. Nsc633557

56. Hsdb 3071

57. Monodox (*monohydrate)

58. Bmy28689

59. Bu 3839t

60. 24390-14-5

61. Einecs 209-271-1

62. Bmy 28689

63. Vibramycin (*monohydrate)

64. 4-epioxytetracycline, 6-deoxy-

65. Gs-3065 (*monohydrate)

66. Doxycycline [usan:inn:ban]

67. Sr-01000075844

68. Unii-334895s862

69. 2-naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4s-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))-

70. Ab08 (*fosfatex)

71. Spectrum_000807

72. (4s,4ar,5s,5ar,6r,12as)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamidehydrochloride

73. Spectrum2_000143

74. Spectrum3_000408

75. Spectrum4_000527

76. Spectrum5_000947

77. Doxycycline [hsdb]

78. Upcmld-dp021

79. Vibramycin, Doxytetracycline

80. Chembl1433

81. Lopac0_000405

82. Schembl40930

83. Schembl66828

84. Bspbio_001936

85. Doxycycline [who-dd]

86. Kbiogr_001133

87. Kbioss_001287

88. Bidd:gt0146

89. Divk1c_000345

90. Spbio_000246

91. Chembl436921

92. Gtpl6464

93. Schembl1176275

94. Dtxsid0037653

95. Schembl17826665

96. Schembl19270298

97. Schembl21753474

98. Upcmld-dp021:001

99. Bcbcmap01_000024

100. Kbio1_000345

101. Kbio2_001287

102. Kbio2_003855

103. Kbio2_006423

104. Kbio3_001156

105. Dtxsid80992212

106. Ninds_000345

107. Doxycycline Anhydrous [mi]

108. Hms2090e06

109. Doxytetracycline; Doxycycline

110. Hy-n0565

111. Lmpk07000001

112. S5159

113. Zinc16052277

114. Anhydrous Doxycycline [mart.]

115. Akos015900372

116. Zinc100056779

117. Zinc100302137

118. Zinc100611210

119. Zinc109562088

120. Ccg-204498

121. Db00254

122. Sdccgsbi-0050391.p005

123. Idi1_000345

124. Smp1_000107

125. Ncgc00161602-01

126. Ncgc00161602-03

127. Ncgc00161602-04

128. Ncgc00161602-05

129. Ncgc00161602-07

130. Ncgc00161602-14

131. Ncgc00188979-01

132. (4s,4ar,5s,5ar,6r,12as)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide

133. 2-naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4s,4ar,5s,5ar,6r,12as)

134. 2-naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4s,4ar,5s,5ar,6r,12as)-

135. 2-naphthacenecarboxamide, 4-alpha-s-(dimethylamino)-1,4,4a-alpha-5,5a-alpha,6,11,12a-octahydro-3,5-alpha,10,12,12a-alpha-pentahydroxy-6-alpha-methyl-1,11-dioxo-

136. As-13499

137. Sbi-0050391.p004

138. Cs-0009105

139. C06973

140. D07876

141. Ab00053465-03

142. Ab00053465_04

143. Ab00053465_05

144. 564d250

145. A817263

146. Doxycycline, Antibiotic For Culture Media Use Only

147. Q422442

148. Sr-01000075844-7

149. Vibramycin;doxytetracycline;doxiciclina;doxycyclinum

150. W-105517

151. Sr-01000075844-18

152. (4s,4ar,5s,5ar,6r,12as)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide

153. 2-naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4s-(4.alpha.,4a.alpha.,5.alpha.,5a.alpha.,6.alpha.,12a.alpha.))-

154. 4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-3,4,4a,5,5a,6,12,12a-octahydrotetracene-2-carboximidic Acid

155. 7164-70-7

2.4 Create Date

2011-12-26

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₂₄N₂O₈
Molecular Weight	444.4 g/mol
XLogP3	-0.7
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	2
Exact Mass	444.15326573 g/mol
Monoisotopic Mass	444.15326573 g/mol
Topological Polar Surface Area	182 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	956
Isotope Atom Count	0
Defined Atom Stereocenter Count	6
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 18
Drug Name	Atridox
PubMed Health	Doxycycline (By mouth)
Drug Classes	Amebicide, Amebicide, Intestinal, Antiacne, Antibiotic, Antimalarial, Antiprotozoal, Dental Agent
Drug Label	Doxycycline is a broad-spectrum antibacterial synthetically derived from oxytetracycline. Monodox 100 mg, 75 mg, and 50 mg capsules contain doxycycline monohydrate equivalent to 100 mg, 75 mg, or 50 mg of doxycycline for oral administration. The chem...
Active Ingredient	Doxycycline hyclate
Dosage Form	System, extended release
Route	Periodontal
Strength	50mg
Market Status	Prescription
Company	Tolmar

2 of 18
Drug Name	Doryx
PubMed Health	Doxycycline (By mouth)
Drug Classes	Amebicide, Amebicide, Intestinal, Antiacne, Antibiotic, Antimalarial, Antiprotozoal, Dental Agent
Active Ingredient	Doxycycline hyclate
Dosage Form	Tablet, delayed release
Route	Oral
Strength	eq 100mg base; eq 80mg base; eq 200mg base; eq 150mg base; eq 75mg base
Market Status	Prescription
Company	Mayne Pharma

3 of 18
Drug Name	Doxy 100
PubMed Health	Doxycycline (Subgingival)
Drug Classes	Antibacterial
Drug Label	DORYX Capsules contain specially coated pellets of doxycycline hyclate, a broad-spectrum antibiotic synthetically derived from oxytetracycline, in a delayed-release formulation for oral administration.The structural formula for doxycycline hyclate is...
Active Ingredient	Doxycycline hyclate
Dosage Form	Injectable
Route	Injection
Strength	eq 100mg base/vial
Market Status	Prescription
Company	Fresenius Kabi Usa

4 of 18
Drug Name	Doxycycline
PubMed Health	Doxycycline
Drug Classes	Amebicide, Amebicide, Intestinal, Antiacne, Antibacterial, Antibiotic, Antimalarial, Antiprotozoal, Dental Agent
Drug Label	Doxycycline for Injection, USP is a sterile, lyophilized powder prepared from a solution of doxycycline hyclate, ascorbic acid and mannitol in Water for Injection. Doxycycline hyclate is a broad spectrum antibiotic derived from oxytetracycline. It is...
Active Ingredient	Doxycycline; Doxycycline hyclate
Dosage Form	Injectable; Tablet; Capsule; For suspension
Route	oral; Injection; Oral
Strength	eq 100mg base; eq 50mg base; eq 150mg base; 40mg; eq 25mg base/5ml; eq 75mg base; eq 100mg base/vial
Market Status	Tentative Approval; Prescription
Company	Mylan Pharms; Ranbaxy; Lannett; Eurohlth Intl; Lupin; Agila Speclts; Chartwell Life Sci; Mylan; Par Pharm; Impax Labs; Heritage Pharms

5 of 18
Drug Name	Doxycycline hyclate
PubMed Health	Doxycycline (Injection)
Drug Classes	Antibiotic, Antimalarial, Antiprotozoal
Drug Label	Doxycycline hyclate is a broad-spectrum antibiotic synthetically derived from oxytetracycline. The structural formula is as follows:with a molecular formula of C22H24N2O8H2O and a molecular weight of 462.46. The chemical designation for doxycycline i...
Active Ingredient	Doxycycline hyclate
Dosage Form	Tablet; Capsule, delayed release; Capsule; Tablet, delayed release
Route	Oral
Strength	eq 100mg base; eq 50mg base; eq 150mg base; eq 20mg base; eq 75mg base
Market Status	Prescription
Company	Corepharma; Mutual Pharma; Vintage Pharms; Mylan Pharms; Blu Caribe; Ivax Sub Teva Pharms; Actavis Elizabeth; Larken Labs; Lannett; Mutual Pharm; Actavis Labs Fl; Medicis; Chartwell Life Sci; Hikma Pharms; Mylan; Impax Labs; Heritage Pharms

6 of 18
Drug Name	Monodox
Drug Label	Vibramycin is an antibacterial drug synthetically derived from oxytetracycline, and is available as Vibramycin Monohydrate (doxycycline monohydrate); Vibramycin Hyclate and Vibra-Tabs (doxycycline hydrochloride hemiethanolate hemihydrate); and Vibram...
Active Ingredient	Doxycycline
Dosage Form	Capsule
Route	Oral
Strength	eq 100mg base; eq 50mg base; eq 75mg base
Market Status	Prescription
Company	Aqua Pharms

7 of 18
Drug Name	Oracea
PubMed Health	Doxycycline
Drug Classes	Amebicide, Amebicide, Intestinal, Antiacne, Antibacterial, Antibiotic, Antimalarial, Antiprotozoal, Dental Agent
Drug Label	Doxycycline hyclate is a broad-spectrum antibiotic synthetically derived from oxytetracycline. The structural formula is as follows:with a molecular formula of C22H24N2O8H2O and a molecular weight of 462.46. The chemical designation for doxycycline i...
Active Ingredient	Doxycycline
Dosage Form	Capsule
Route	Oral
Strength	40mg
Market Status	Prescription
Company	Galderma Labs

8 of 18
Drug Name	Periostat
PubMed Health	Doxycycline
Drug Classes	Amebicide, Amebicide, Intestinal, Antiacne, Antibacterial, Antibiotic, Antimalarial, Antiprotozoal, Dental Agent
Drug Label	ORACEA (doxycycline, USP) Capsules 40 mg are hard gelatin capsule shells filled with two types of doxycycline beads (30 mg immediate release and 10 mg delayed release) that together provide a dose of 40 mg of anhydrous doxycycline (C22H24N2O8).The st...
Active Ingredient	Doxycycline hyclate
Dosage Form	Tablet
Route	Oral
Strength	eq 20mg base
Market Status	Prescription
Company	Galderma Labs

9 of 18
Drug Name	Vibramycin
Active Ingredient	Doxycycline calcium; Doxycycline hyclate; Doxycycline
Dosage Form	Capsule; Suspension; For suspension
Route	Oral
Strength	eq 100mg base; eq 50mg base; eq 50mg base/5ml; eq 25mg base/5ml
Market Status	Prescription
Company	Pfizer

10 of 18
Drug Name	Atridox
PubMed Health	Doxycycline (By mouth)
Drug Classes	Amebicide, Amebicide, Intestinal, Antiacne, Antibiotic, Antimalarial, Antiprotozoal, Dental Agent
Drug Label	Doxycycline is a broad-spectrum antibacterial synthetically derived from oxytetracycline. Monodox 100 mg, 75 mg, and 50 mg capsules contain doxycycline monohydrate equivalent to 100 mg, 75 mg, or 50 mg of doxycycline for oral administration. The chem...
Active Ingredient	Doxycycline hyclate
Dosage Form	System, extended release
Route	Periodontal
Strength	50mg
Market Status	Prescription
Company	Tolmar

11 of 18
Drug Name	Doryx
PubMed Health	Doxycycline (By mouth)
Drug Classes	Amebicide, Amebicide, Intestinal, Antiacne, Antibiotic, Antimalarial, Antiprotozoal, Dental Agent
Active Ingredient	Doxycycline hyclate
Dosage Form	Tablet, delayed release
Route	Oral
Strength	eq 100mg base; eq 80mg base; eq 200mg base; eq 150mg base; eq 75mg base
Market Status	Prescription
Company	Mayne Pharma

12 of 18
Drug Name	Doxy 100
PubMed Health	Doxycycline (Subgingival)
Drug Classes	Antibacterial
Drug Label	DORYX Capsules contain specially coated pellets of doxycycline hyclate, a broad-spectrum antibiotic synthetically derived from oxytetracycline, in a delayed-release formulation for oral administration.The structural formula for doxycycline hyclate is...
Active Ingredient	Doxycycline hyclate
Dosage Form	Injectable
Route	Injection
Strength	eq 100mg base/vial
Market Status	Prescription
Company	Fresenius Kabi Usa

13 of 18
Drug Name	Doxycycline
PubMed Health	Doxycycline
Drug Classes	Amebicide, Amebicide, Intestinal, Antiacne, Antibacterial, Antibiotic, Antimalarial, Antiprotozoal, Dental Agent
Drug Label	Doxycycline for Injection, USP is a sterile, lyophilized powder prepared from a solution of doxycycline hyclate, ascorbic acid and mannitol in Water for Injection. Doxycycline hyclate is a broad spectrum antibiotic derived from oxytetracycline. It is...
Active Ingredient	Doxycycline; Doxycycline hyclate
Dosage Form	Injectable; Tablet; Capsule; For suspension
Route	oral; Injection; Oral
Strength	eq 100mg base; eq 50mg base; eq 150mg base; 40mg; eq 25mg base/5ml; eq 75mg base; eq 100mg base/vial
Market Status	Tentative Approval; Prescription
Company	Mylan Pharms; Ranbaxy; Lannett; Eurohlth Intl; Lupin; Agila Speclts; Chartwell Life Sci; Mylan; Par Pharm; Impax Labs; Heritage Pharms

14 of 18
Drug Name	Doxycycline hyclate
PubMed Health	Doxycycline (Injection)
Drug Classes	Antibiotic, Antimalarial, Antiprotozoal
Drug Label	Doxycycline hyclate is a broad-spectrum antibiotic synthetically derived from oxytetracycline. The structural formula is as follows:with a molecular formula of C22H24N2O8H2O and a molecular weight of 462.46. The chemical designation for doxycycline i...
Active Ingredient	Doxycycline hyclate
Dosage Form	Tablet; Capsule, delayed release; Capsule; Tablet, delayed release
Route	Oral
Strength	eq 100mg base; eq 50mg base; eq 150mg base; eq 20mg base; eq 75mg base
Market Status	Prescription
Company	Corepharma; Mutual Pharma; Vintage Pharms; Mylan Pharms; Blu Caribe; Ivax Sub Teva Pharms; Actavis Elizabeth; Larken Labs; Lannett; Mutual Pharm; Actavis Labs Fl; Medicis; Chartwell Life Sci; Hikma Pharms; Mylan; Impax Labs; Heritage Pharms

15 of 18
Drug Name	Monodox
Drug Label	Vibramycin is an antibacterial drug synthetically derived from oxytetracycline, and is available as Vibramycin Monohydrate (doxycycline monohydrate); Vibramycin Hyclate and Vibra-Tabs (doxycycline hydrochloride hemiethanolate hemihydrate); and Vibram...
Active Ingredient	Doxycycline
Dosage Form	Capsule
Route	Oral
Strength	eq 100mg base; eq 50mg base; eq 75mg base
Market Status	Prescription
Company	Aqua Pharms

16 of 18
Drug Name	Oracea
PubMed Health	Doxycycline
Drug Classes	Amebicide, Amebicide, Intestinal, Antiacne, Antibacterial, Antibiotic, Antimalarial, Antiprotozoal, Dental Agent
Drug Label	Doxycycline hyclate is a broad-spectrum antibiotic synthetically derived from oxytetracycline. The structural formula is as follows:with a molecular formula of C22H24N2O8H2O and a molecular weight of 462.46. The chemical designation for doxycycline i...
Active Ingredient	Doxycycline
Dosage Form	Capsule
Route	Oral
Strength	40mg
Market Status	Prescription
Company	Galderma Labs

17 of 18
Drug Name	Periostat
PubMed Health	Doxycycline
Drug Classes	Amebicide, Amebicide, Intestinal, Antiacne, Antibacterial, Antibiotic, Antimalarial, Antiprotozoal, Dental Agent
Drug Label	ORACEA (doxycycline, USP) Capsules 40 mg are hard gelatin capsule shells filled with two types of doxycycline beads (30 mg immediate release and 10 mg delayed release) that together provide a dose of 40 mg of anhydrous doxycycline (C22H24N2O8).The st...
Active Ingredient	Doxycycline hyclate
Dosage Form	Tablet
Route	Oral
Strength	eq 20mg base
Market Status	Prescription
Company	Galderma Labs

18 of 18
Drug Name	Vibramycin
Active Ingredient	Doxycycline calcium; Doxycycline hyclate; Doxycycline
Dosage Form	Capsule; Suspension; For suspension
Route	Oral
Strength	eq 100mg base; eq 50mg base; eq 50mg base/5ml; eq 25mg base/5ml
Market Status	Prescription
Company	Pfizer

4.2 Therapeutic Uses

Antibiotics, Tetracycline

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

AGAINST GRAM-POSITIVE BACTERIA IT IS ABOUT TWICE AS POTENT AS TETRACYCLINE, EXCEPT THAT IT IS UP TO 10 TIMES AS POTENT AGAINST STREP VIRIDANS. FURTHERMORE, STRAINS OF STREP FAECALIS THAT ARE RESISTANT TO OTHER TETRACYCLINES MAY BE SENSITIVE TO DOXYCYCLINE.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1140

DOSE OF DOXYCYCLINE FOR ADULTS IS 100 MG EVERY 12 HR DURING FIRST 24 HR, FOLLOWED BY 100 MG ONCE DAY, OR TWICE DAILY WHEN SEVERE INFECTION IS PRESENT. CHILDREN OVER 8 YR SHOULD RECEIVE 4-5 MG/KG/DAY, DIVIDED INTO 2 EQUAL DOSES GIVEN @ 12 HR INTERVAL DURING FIRST DAY, AFTER WHICH SINGLE DOSE OF HALF THIS AMT IS ADMIN.

Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 1120

AFFINITY OF DOXYCYCLINE FOR METALLIC IONS MAY NOT BE AS GREAT AS THAT OF OTHER TETRACYCLINES SINCE IT CAN BE GIVEN WITH FOOD OR MILK WITHOUT SIGNIFICANT INACTIVATION OR IMPAIRMENT OF ABSORPTION.

American Medical Association, AMA Department of Drugs, AMA Drug Evaluations. 3rd ed. Littleton, Massachusetts: PSG Publishing Co., Inc., 1977., p. 746

For more Therapeutic Uses (Complete) data for DOXYCYCLINE (27 total), please visit the HSDB record page.

4.3 Drug Warning

TETRACYCLINES SHOULD NOT BE ADMIN TO PREGNANT OR NURSING WOMEN & CHILDREN UNDER 8 YR UNLESS THERE ARE COMPELLING REASONS TO DO SO.

American Medical Association. AMA Drug Evaluations Annual 1991. Chicago, IL: American Medical Association, 1991., p. 1298

TREATMENT OF PREGNANT PATIENTS ... MAY PRODUCE DISCOLORATION OF TEETH IN THEIR OFFSPRING. ... CHILDREN UP TO 8 YR OLD MAY BE SUSCEPTIBLE ... TETRACYCLINES ARE DEPOSITED IN SKELETON DURING GESTATION. ... 40% DEPRESSION OF BONE GROWTH ... DEMONSTRATED IN PREMATURE INFANTS TREATED WITH THESE AGENTS. /TETRACYCLINES/

Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 1122

TETRACYCLINES POSE SPECIAL DANGER IN PREGNANT WOMEN, WITH RESPECT TO POSSIBLE HEPATIC INJURY, PARTICULARLY IF USED FOR TREATMENT OF PYELONEPHRITIS, RELATIVELY COMMON OCCURRENCE IN SUCH PATIENTS INDEED, FATALITIES HAVE OCCURRED. /TETRACYCLINES/

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1188

IT SHOULD BE EMPHASIZED THAT CROSS-SENSITIZATION AMONG VARIOUS TETRACYCLINES IS COMMON.

Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 1122

For more Drug Warnings (Complete) data for DOXYCYCLINE (12 total), please visit the HSDB record page.

4.4 Drug Indication

Doxycycline is indicated for the treatment of various infections by gram-positive and gram-negative bacteria, aerobes and anaerobes, as well other types of bacteria. A complete list of organisms is available in the FDA label and in the "indications" section of this drug entry. The following are some of the major infections that may be treated with doxycycline: Rocky mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae Respiratory tract infections caused by Mycoplasma pneumoniae Lymphogranuloma venereum caused by Chlamydia trachomatis Psittacosis (ornithosis) caused by Chlamydia psittaci Trachoma caused by Chlamydia trachomatis, although the infectious agent is not always eliminated as judged by immunofluorescence Inclusion conjunctivitis caused by Chlamydia trachomatis Uncomplicated urethral, endocervical or rectal infections in adults caused by Chlamydia trachomatis Nongonococcal urethritis caused by Ureaplasma urealyticum Relapsing fever due to Borrelia recurrentis **A note regarding anti-microbial resistance** It is important to note that doxycycline is not the drug of choice in the treatment of any type of staphylococcal infection. Up to 44 percent of strains of Streptococcus pyogenes and 74 percent of Streptococcus faecalis have been found to be resistant to tetracyclines. Therefore, tetracyclines such as doxycycline should not be used to treat streptococcal infections unless the microorganism has been demonstrated to be susceptible.

FDA Label

Treatment of periodontal disease in dogs.

Periodontal pocket probing depths > =4 mm are evidence of disease that may be responsive to treatment with the Doxirobe Gel. Use of this product as directed should result in attachment level gains, periodontal pocket depth reductions, local antimicrobial effect and improved gingival health. Noticeable improvements in these parameters should be evident within 2-4 weeks following treatment. The response in individual dogs is dependent on the severity of the condition and rigor of adjunctive therapy.

5 Pharmacology and Biochemistry

5.1 Pharmacology

The tetracyclines, including doxycycline, are mainly bacteriostatic and are thought to exert antimicrobial effects by the inhibition of protein synthesis. Bacteriostatic antibiotics suppress the growth of bacteria, or keep them in the stationary phase of growth. The tetracyclines, including doxycycline, have a similar antimicrobial spectrum of activity against a variety of gram-positive and gram-negative microorganisms, treating numerous infectious diseases. Cross-resistance of these microorganisms to tetracyclines is a common occurrence. Doxycycline shows favorable intra-cellular penetration, with bacteriostatic activity on a wide range of bacteria. Doxycycline has antiparasitic effects,,. In addition to the above effects, this drug has demonstrated anti-inflammatory actions, which may help to manage inflammatory conditions such as rosacea.

5.2 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

Antimalarials

Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) (See all compounds classified as Antimalarials.)

5.3 FDA Pharmacological Classification

5.3.1 Active Moiety

DOXYCYCLINE ANHYDROUS

5.3.2 FDA UNII

334895S862

5.3.3 Pharmacological Classes

Tetracyclines [CS]; Tetracycline-class Drug [EPC]

5.4 ATC Code

QJ01AA02

J01AA02

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

A - Alimentary tract and metabolism

A01 - Stomatological preparations

A01A - Stomatological preparations

A01AB - Antiinfectives and antiseptics for local oral treatment

A01AB22 - Doxycycline

J - Antiinfectives for systemic use

J01 - Antibacterials for systemic use

J01A - Tetracyclines

J01AA - Tetracyclines

J01AA02 - Doxycycline

5.5 Absorption, Distribution and Excretion

Absorption

Tetracyclines, such as doxycycline, are readily absorbed and are bound to plasma proteins by varying degrees. Doxycycline is almost completely absorbed after oral administration. This drug is highly lipid soluble and has a low affinity for calcium binding. Absorption is not significantly affected by the concomitant ingestion of food or milk. Peak serum levels of approximately 2.6 mcg/ml are reached at 2 hours following a 200 mg tablet oral dose.

Route of Elimination

Mainly the urine and feces as active and unchanged drug. Between 40% and 60% of an administered dose can be accounted for in the urine by 92 hours, and approximately 30% can be accounted for in the feces.

Volume of Distribution

Doxycycline diffuses readily into most body tissues, fluid and/or cavities and the volume of distribution has been measured as 0.7 L/kg.

Clearance

The excretion of doxycycline by the kidney is about 40% over 72 hours in individuals with normal kidney function (creatinine clearance approximately 75 mL/min). This rate may fall as low as 1-5% over 72 hours in individuals with severe renal insufficiency (creatinine clearance below 10 mL/min). Some clinical studies have shown no major difference in serum half-life of doxycycline (range 18-22 hours) in patients with normal and severely impaired renal function. Hemodialysis does not affect serum half-life of doxycycline.

RELATIVE INSENSITIVITY OF DOXYCYCLINE PHARMACOKINETICS TO RENAL INSUFFICIENCY HAS ... BEEN DEMONSTRATED IN HUMANS & APPEARS TO BE ASSOC WITH INCR FECAL EXCRETION OWING TO DIFFUSION OF DRUG INTO LUMEN OF SMALL INTESTINE. ... RENAL CLEARANCE OF ACTIVE ANTIBIOTIC IS ... 20 ... ML/MIN FOR DOXYCYCLINE ... .

The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 174

SERUM LEVELS OF DOXYCYCLINE ARE EQUIV WHETHER DRUG IS DOSED BY IV OR PER OS ROUTE. AFTER MULTIPLE DAILY IV DOSES OF 200 MG, SERUM LEVELS ... FLUCTUATED BETWEEN 5-6 & 1-2 UG/ML, WHICH IS ABOVE MIN INHIBITORY CONCN FOR MOST SUSCEPTIBLE PATHOGENS.

The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 174

URINARY EXCRETION OF ... DOXYCYCLINE IS INCR @ HIGH URINARY PH VALUES. ALKALINE TREATMENT OF SUBJECTS RESULTED IN 24% INCR IN CUMULATIVE URINARY TETRACYCLINE EXCRETION COMPARED WITH ACID TREATMENT (P< 0.05) & 54% INCR FOR DOXYCYCLINE (P LESS THAN 0.05). RENAL CLEARANCE ... INCR DURING ALKALINE TREATMENT ... .

The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 173

... MORE COMPLETELY ABSORBED AFTER ORAL ADMIN THAN OTHER TETRACYCLINES ... IN PLASMA, IT IS ABOUT 90% PROTEIN BOUND, WHICH IS HIGHEST DEGREE FOR ANY OF TETRACYCLINES.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1140

For more Absorption, Distribution and Excretion (Complete) data for DOXYCYCLINE (20 total), please visit the HSDB record page.

5.6 Metabolism/Metabolites

Doxycycline is metabolized in the liver and gastrointestinal tract and concentrated in bile,. Major metabolic pathways of doxycycline have not been identified, however, enzyme inducers have been found to decrease the half-life of doxycycline.

/DOXYCYCLINE/ IS EXCRETED IN FECES (UP TO 90%) AS INACTIVE CONJUGATE OR PERHAPS AS CHELATE.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1186

Although it was previously suggested that doxycycline is partially metabolized in the liver, recent studies indicate that the drug is not metabolized but is partially deactivated in the intestine by chelate formation.

McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 93. Bethesda, MD: American Society of Hospital Pharmacists, Inc., 1993 (Plus Supplements, 1993)., p. 319

5.7 Biological Half-Life

16.33 hr ( 4.53 sd).

DOXYCYCLINE: ROUTES OF EXCRETION: HEPATIC, RENAL; NORMAL HALF-LIFE: 20 HR; MAINTENANCE DOSE INTERVALS: 12-24 HR.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1109

DOXYCYCLINE IS LONG-ACTING, HAVING SERUM HALF-LIFE OF 15-17 HR AFTER INITIAL DOSE & ABOUT 22 HR AFTER 4TH DAY OF TREATMENT.

American Medical Association, AMA Department of Drugs, AMA Drug Evaluations. 3rd ed. Littleton, Massachusetts: PSG Publishing Co., Inc., 1977., p. 736

The serum half-life of doxycycline is 14-17 hr after a single dose and 22-24 hr after multiple doses in patients with normal renal function. In patients with severe renal impairment, the serum half-life of doxycycline is reported to be 18-26 hr after a single dose, and 20-30 hr after multiple doses. It appears that serum half-life of doxycycline is not altered in patients undergoing hemodialysis. In patients with normal renal function, approximately 20-26% of a single oral or iv dose of doxycycline is excreted in urine and 20-40% is excreted in feces within 48 hr as active drug. In patients with creatinine clearances less than 10 ml/minute, the fraction of doxycycline excreted in urine within 72 hr may decrease to about 1-5%.

McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 93. Bethesda, MD: American Society of Hospital Pharmacists, Inc., 1993 (Plus Supplements, 1993)., p. 319

5.8 Mechanism of Action

In bacterial replication, an interaction that is important for translation initiation of proteins occurs at the 3 end of the 16S rRNA, found on the ribosome on the 30S subunit,,. The 30S subunit is the smaller subunit of the ribosome of prokaryotes, including bacteria. Tetracyclines such as doxycycline are thought to inhibit translation by binding to the 16S rRNA portion of the ribosome, preventing binding of tRNA to the RNA-30S bacterial ribosomal subunit, which is necessary for the delivery of amino acids for protein synthesis. As a result of the above actions, the initiation of protein synthesis by polyribosome formation is blocked. This stops the replication of bacteria and produces a bacteriostatic effect.

TETRACYCLINES INHIBIT BACTERIAL PROTEIN SYNTHESIS. ... ONCE TETRACYCLINES GAIN ACCESS TO THE BACTERIAL CELL, THEY BIND PRINCIPALLY TO 30 S SUBUNITS OF BACTERIAL RIBOSOMES. THEY APPEAR TO PREVENT ACCESS OF AMINOACYL T-RNA TO M-RNA-RIBOSOME COMPLEX. ... ONLY SMALL PORTION OF DRUG IS IRREVERSIBLY BOUND, & INHIBITORY EFFECTS OF THE TETRACYCLINESARE REVERSIBLE WHEN THE DRUG IS REMOVED. /TETRACYCLINES/

Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 1118

API SUPPLIERS

01

Rochem International Inc

U.S.A

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DKSH

Switzerland

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Hovione

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DKSH

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DKSH, founded with the goal of improving people's lives, assists businesses with market expansion and business growth in both existing and emerging markets. It has been fostering growth for businesses in Asia and beyond for over 155 years. DKSH operates in 36 markets, is listed on the SIX Swiss Exchange, employs 33,100 specialists, and generated net sales of CHF 11.1 billion in 2021. It is the leading global distributor of innovative pharma ingredients for pharmaceutical synthesis and formulation. It offers a range of products, ranging from animal care products to packaging materials, intermediates to nutraceuticals, and APIs to excipients.

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API Reference Price

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ROAD,","city":"MUMBAI,MAHARASHTRA","supplier":"M\/S. HOVIONE HOLDING ASIA LIMITED","supplierCountry":"MACAU ISLANDS","foreign_port":"MACAO","customer":"LUPIN LTD","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"500","totalValueFC":"50575.3","currency":"USD","unitRateINR":"42496.7","date":"29-Oct-2024","totalValueINR":"4249666.23","totalValueInUsd":"50575.3","indian_port":"Bombay Air","hs_no":"29413010","bill_no":"6388753","productDescription":"API","marketType":"","country":"MACAU ISLANDS","selfForZScoreResived":"Micronized","supplierPort":"MACAO","supplierAddress":"AUBIN HOUSE, 11TH FLOOR. 171-172 GL OUCESTER ROAD, WANCHAI - HONG KONG Hong Kong, , Hong Kong Hong Kong","customerAddress":"159, C.S.T. ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730140200,"product":"DOXYCYCLINE HYCLATE","address":"8, SAVANI APARTMENT, M.G.ROAD,","city":"MUMBAI,MAHARASHTRA","supplier":"SHANGHAI MOONSHINE TECHNOLOGY ","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"VIDACARE MEDICA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"750.00","actualQuantity":"750","unit":"KGS","unitRateFc":"42.8","totalValueFC":"32588.4","currency":"USD","unitRateINR":"3651.1","date":"29-Oct-2024","totalValueINR":"2738293.62","totalValueInUsd":"32588.4","indian_port":"JNPT","hs_no":"29413010","bill_no":"6400264","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO 789,TIANZHU ROAD JIADING DISTRICT SHANGHAI CN","customerAddress":"8, SAVANI APARTMENT, M.G.ROAD,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - CAPSULE;ORAL - EQ 100MG BASE

USFDA APPLICATION NUMBER - 50641

DOSAGE - CAPSULE;ORAL - EQ 150MG BASE

USFDA APPLICATION NUMBER - 50641

DOSAGE - CAPSULE;ORAL - EQ 50MG BASE

USFDA APPLICATION NUMBER - 50641

DOSAGE - CAPSULE;ORAL - EQ 75MG BASE

USFDA APPLICATION NUMBER - 50641

DOSAGE - CAPSULE;ORAL - 40MG

USFDA APPLICATION NUMBER - 50805

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CAPSULE;ORAL - EQ 100MG BASE

CAPSULE;ORAL - EQ 150MG BASE

CAPSULE;ORAL - EQ 50MG BASE

CAPSULE;ORAL - EQ 75MG BASE

CAPSULE;ORAL - 40MG

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